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How molecules get to the right place at the right time
Date:4/20/2011

vidual proteins is not sufficient for selection of transcripts for transport. She2p, She3p and mRNA must come together to permit formation of a stable and specific complex."

Moreover, the two proteins check the passenger tickets, so to speak, because the complex remains stable only if the mRNA carries a particular molecular label that earmarks it as cargo. If the label is missing, the complex rapidly disintegrates. "Our results demonstrate yet again how little we know about this essential cellular process," says Niessing. "It will take a whole series of analogous experiments to understand the mechanistic similarities and differences between the systems that mediate molecular transport in simple unicellular and sophisticated multicellular organisms." (suwe)


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Contact: Luise Dirscherl
dirscherl@lmu.de
49-892-180-2706
Ludwig-Maximilians-Universitt Mnchen
Source:Eurekalert

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