Navigation Links
How molecular muscles help cells divide
Date:12/14/2007

Pollard. This is important because it shows for the first time how the contractile machinery assembles and how all the pieces get to the right place to get the job done.

Time-lapse imaging and computer modeling demonstrated that cells undergoing mitosis set up small clusters of proteins, or nodes, on the inside of the cell membrane around the equator of the cell. Proteins in these nodes begin to put out a small number of filaments composed of the protein actin. The filaments grow in random directions until they encounter another node, where myosin motors in the contacted node pull on the actin filament, bringing the two nodes together.

However, the researchers found that each connection is broken in about 20 seconds. Releasing the connections and initiating subsequent rounds of search and capture appears essential to the assembly process, say the scientists. The assembly involves many episodes of attractions between pairs of nodes proceeding in parallel. Eventually the nodes form into a condensed contractile ring around the equator, ready to pinch the mother into two daughters at a later stage.

A novel and important aspect of this work was that we used computer simulations at every step to test what is feasible physically and to guide our experiments, said author Ben OShaughnessy, professor of chemical engineering at Columbia. The simulations show that cells use reaction rates that are nearly ideal to make this mechanism work on the time scale of the events in the cells.

Future work will involve testing the concepts learned from fission yeast in other cells to learn if the mechanism is universal, said Pollard. Since other cells, including human cells, depend on similar proteins for cytokinesis [cell division], it is entirely possible that they use the same strategy.


'/>"/>

Contact: Janet Rettig Emanuel
janet.emanuel@yale.edu
203-432-2157
Yale University  
Source:Eurekalert

Page: 1 2

Related biology news :

1. New molecular regulators of hyperthyroidism and goiter
2. Carnegie Mellon scientists investigate initial molecular mechanism that triggers neuronal firing
3. UC health news: molecular pathway may predict chemotherapy effectiveness
4. New molecular clock from LLNL and CDC indicates smallpox evolved earlier than believed
5. Story ideas from Molecular & Cellular Proteomics
6. Lets talk -- new paradigms in the research of the biomolecular composition of water
7. Scientists unveil structure of molecular target of many drugs
8. Potential new therapeutic molecular target to fight cancer
9. NIH selects LIAI for major study on allergy molecular causes and possible treatments
10. Pennsylvania Hospital surgeon receives grant to develop molecular cardiac surgery
11. Leading cause of death in preemies might be controlled by resetting a molecular switch
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
How molecular muscles help cells divide
(Date:7/11/2014)... available in German . ... that uses the refraction of X-rays through a specimen ... with this method are often of much higher quality ... team of Prof. Franz Pfeiffer are particularly interested in ... including X-ray phase-contrast imaging. One main goal is ...
(Date:7/11/2014)... group members to reduce aggression and gain access to ... grooming activities shows a certain pattern across the day. ... Biology Letters . , Grooming between individuals in ... motives. To be groomed has hygienic benefits and is ... can provide access to infants, mating opportunities and high ...
(Date:7/11/2014)... transplantation of mesenchymal stem cells can stimulate neurogenesis in ... Alzheimer,s disease (AD) and improve tissue and function injury ... reported on the therapeutic effect of adipose-derived stem cells ... effect on oxidative injury and neurogenesis in the brain ... School of Life Sciences, Tsinghua University, China transplanted ADSCs ...
Breaking Biology News(10 mins):New simple setup for X-ray phase contrast 2Baboons groom early in the day to get benefits later 2
... victory gardens helped World War II era Americans on ... been as necessary and popular as they are today. ... the produce grown there becomes increasingly important. As ... vegetables for family consumption and planning ahead for the ...
... CITY, Sept. 27, 2010 If drivers are yakking on cell phones ... passenger or navigation system, they still can get directions from devices that ... index fingertips left or right, a University of Utah study found. ... The researchers say they don,t want their results to encourage dangerous and ...
... Santa Cruz, CA, USA and Oxford, UK, 27 ... Nanotechnology shows a new method of enzyme-controlled movement ... nanopore. The paper, by researchers at the University ... towards nanopore sequencing of DNA strands. The publication describes ...
Cached Biology News:Urban gardeners beware: There may be lead in your soil and food 2Let your fingers do the driving 2Let your fingers do the driving 3Let your fingers do the driving 4Let your fingers do the driving 5Nature Nanotechnology paper shows enzyme-controlled movement of DNA polymer through a nanopore 2
(Date:7/10/2014)... the basis of psychiatric disorders has been extremely challenging ... risk but are insufficient to cause disease. Now investigators ... Press journal Cell Stem Cell describe a ... risks interact with other risk factors or environmental exposures ... research pinpoints a genetic variant that may predispose individuals ...
(Date:7/10/2014)... RICHLAND, Wash. The lithium-ion batteries that power our ... run longer on a single charge with the help ... the porous material to replace the graphite traditionally used ... more than 10 times the energy storage capacity of ... lithium-ion battery electrode was published today in Nature ...
(Date:7/10/2014)... shelled out for crude 3-D glasses, polarized glasses, ... These basic devices, used to trick the brain ... be rendered obsolete with the introduction of new ... , TAU doctoral students Yuval Yifat, Michal Eitan, ... based on nanoantennas that could be used for ...
(Date:7/10/2014)... new alliance will see the two universities and NPL ... with business and industry and their complementary academic strengths., ... help to shape the scientific priorities of the UK. ... up to 300 high-calibre PhD students, will provide a ... NPL, the potential of the Laboratory will be grown ...
Breaking Biology Technology:New strategy could uncover genes at the root of psychiatric illnesses 2Silicon sponge improves lithium-ion battery performance 2Silicon sponge improves lithium-ion battery performance 3Projecting a 3-dimensional future 2Projecting a 3-dimensional future 3Universities of Surrey and Strathclyde selected as strategic partners in the future operation of the National Physical Laboratory 2Universities of Surrey and Strathclyde selected as strategic partners in the future operation of the National Physical Laboratory 3
... March 18 Syndication Inc., (Pink Sheets: SYNJ), Reports ... of ,Director of Technical Engineering,. The job of the ... budget development of the Company,s Pinnacle Energy Division. The ... wind turbine energy, bio-diesel fuel production, and microwave plasma ...
... 11dhTxB2 to assess aspirin effectDENVER, March 18 ... worldwide developer and marketer of diagnostic test kits, ... Test March 29 - 31 at the American ... The annual meeting will take place in Orlando, ...
... Despite the initial regulatory hiccups, the number of ... increase gradually. The patent expiry of key biopharmaceuticals ... driving the development of biosimilars. In addition, payers, ... drugs due to their safety, efficacy and affordability, ...
Cached Biology Technology:Syndication Inc. Seeks 'DIRECTOR OF TECHNICAL ENGINEERING' for 'PINNACLE ENERGY' - Its New Alternative Energy Subsidiary 2Corgenix to Exhibit AspirinWorks(R) Test at ACC.09 2Corgenix to Exhibit AspirinWorks(R) Test at ACC.09 3The Need for Safe and Affordable Biopharmaceuticals Drives the Development of the European Biosimilars Market, Says Frost & Sullivan 2The Need for Safe and Affordable Biopharmaceuticals Drives the Development of the European Biosimilars Market, Says Frost & Sullivan 3The Need for Safe and Affordable Biopharmaceuticals Drives the Development of the European Biosimilars Market, Says Frost & Sullivan 4
... The new Adept CE 4100 high ... superb flow precision, with software drive compensation, ... from 0.001-10mL/min are selectable in 0.001mL steps. ... are inert and bio-compatible., Pumps may be ...
... angle system, 220-240 V, is used to resolve ... fragments by pulsed field gel electrophoresis (PFGE). The ... pump, 14 x 13 cm casting stand with ... thick comb, screened cap, disposable plug molds, 12 ...
... Immuno-Blot PVDF membrane and filter paper ... PVDF membrane and two sheets of thick ... blotting membrane and filter paper sandwich. These ... high binding capacity immunoblotting fit Ready Gel-sized ...
... fromStreptomyces griseolusthat inhibits protein synthesis. Acts ... eukaryote ribosomes. Reported to induce apoptosis ... promyelocytic leukemia cells, Jurkat cells, ventricular ... intracellular signals and immediate early gene ...
Biology Products: