Navigation Links
How mitochondria get their membranes bent
Date:6/24/2009

This release is available in German.

Mitochondria are the powerhouses of cells. Underneath their smooth surface they harbor an elaborately folded inner membrane. It holds a multitude of bottleneck like invaginations, which expand into elongated cavities (cristae). The narrow shape of the entrance or pore to the cristae ('crista junction') allows separation of the intracristal space and storage of molecules. Cytochrome c, for example, an important signaling protein in programmed cell death (apoptosis), is stored in this compartment. When apoptosis is triggered, the pores enlarge and cytochrome c is released into the cytosol. Thus, understanding of how the pore diameter and the shape of the inner membrane are regulated on a molecular basis is of great relevance to a better understanding of mitochondrial function in general. Recently, in cooperation with other research teams, the group of Prof. Andreas Reichert, who has been appointed as professor for Mitochondrial Biology to the Goethe University within the Cluster of Excellence Macromolecular Complexes in 2007, has identified two proteins linked in an antagonistic manner that are relevant for governing inner membrane structure.

In the current issue of the the Journal of Cell Biology Rabl, Soubannier et al. report on their quest of slow-growing baker`s yeast mutants harboring deformed mitochondria. Thereby, they discovered the protein Fcj1 ("Formation of criasta junction protein 1"), which is embedded in the inner membrane and accumulates at crista junctions. Upon increased expression of Fcj1 the number of cristae junctions goes up. Without the protein, however, crista junctions are lacking and the inner cristae membrane forms internal parallel stacks of vesicles.

On the other hand, the researchers found that regular assemblies (supercomplexes) of the F1FO-ATPase, a protein complex re
'/>"/>

Contact: Dr. Andreas Reichert
reichert@zbc.kgu.de
49-696-301-87135
Goethe University Frankfurt
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
2. Zebrafish to shed light on human mitochondrial diseases
3. New chemical tool kit manipulates mitochondria, reveals insights into drug toxicity
4. Mitochondrial dysfunction and redox signaling in atrial tachyarrhythmia
5. Hebrew University develops novel approach for treating mitochondrial disorders
6. Mitochondrial cholesterol makes response to chemotherapy difficult in hepatic cancer
7. Large reservoir of mitochondrial DNA mutations identified in humans
8. A link between mitochondria and tumor formation in stem cells
9. Mitochondria could be a target for therapeutic strategy for Alzheimers disease patients
10. Protein regulates movement of mitochondria in brain cells
11. ESF EURYI award winner aims to stop cancer cells reading their own DNA
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/15/2014)... Miami could know as early as 2020 how high ... to a team of researchers including Florida International University ... the National Science Foundation,s (NSF) Florida Coastal Everglades Long-Term ... LTER sites in ecosystems from coral reefs to deserts, ... conclude that sea level rise is one of the ...
(Date:4/15/2014)... UC San Diego have succeeded in visualizing the ... for growth and resistance to drought. The achievement ... determine how the hormone helps plants respond to ... continuing increase in the atmosphere,s carbon dioxide, or ... in the April 15 issue of the scientific ...
(Date:4/15/2014)... found a less invasive way to extract single ... how the mouth,s natural defenses ward off infection ... cells (white blood cells known as "leukocytes") to ... reject foreign tissues, such as in failed organ ... preventing such health issues as oral cancers, cardiovascular ...
Breaking Biology News(10 mins):Long-term predictions for Miami sea level rise could be available relatively soon 2Biologists develop nanosensors to visualize movements and distribution of plant hormone 2New method isolates immune cells for researchers to study how they ward off oral diseases 2
... Foundation announced that it will provide $200,000 in 2009 to ... treatment for Rett Syndrome. The study will be carried ... Boston Children,s Hospital, led by Dr. Omar Khwaja MD, PhD ... to be tested in Rett syndrome patients. Investigators will ...
... 2009 CryoLife, Inc. (NYSE: CRY) Elite cardiovascular surgeons ... week for the two-day Ross Summit to review and discuss ... Ross Procedure and to practice the technical nuances required to ... is a type of specialized aortic valve surgery in which ...
... 21, 2009 -- Investigators at Burnham Institute for ... for the enzyme caspase-3 (an enzyme that proteolytically ... called N-terminomics, Guy Salvesen, Ph.D., professor and director ... of Burnham,s NCI-designated Cancer Center, and colleagues determined ...
Cached Biology News:IRSF announces funding of first clinical trial with disease-modifying therapy for Rett syndrome 2Growing outcomes evidence spurs renewed interest in unique heart valve procedure 2How proteins talk to each other 2
(Date:1/15/2014)... 2014 The Microcompetition with Foreign DNA ... disease. One of these latent viruses is the Epstein ... rheumatoid arthritis (RA). Rheumatoid arthritis (RA) is a chronic ... by the theory, a study found that RA patients ... (1). , What is Microcompetition? , Dr. Hanan ...
(Date:1/15/2014)... Sunnyvale, CA (PRWEB) January 15, 2014 ... of high throughput research solutions, today announced that ... companies, has received delivery of Freeslate’s CM ... form screening. , Lupin, headquartered in Mumbai, ... quality, affordable generic and branded formulations and Active ...
(Date:1/14/2014)... (PRWEB) January 14, 2014 Date: Friday, ... p.m. , Location: Warrington Country Club, 1360 Almshouse Road, ... Foundation, the only national nonprofit organization solely dedicated to ... quality of life for those affected worldwide, will host ... Warrington Country Club in Warrington, Pa. , Each ...
(Date:1/14/2014)... , Jan. 14, 2014  3D Communications, a leading provider ... major scientific, regulatory, business, and media events in ... , today announced its former associate Virginia Cox , ... office. Virginia Cox re-joins ... Commissioner for the Office of External Affairs at the U.S. ...
Breaking Biology Technology:Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3Hepatitis B Foundation to Host Annual Crystal Ball Gala 2Former FDA Associate Commissioner Returns To 3D Communications 2
... Standard Networks announced Tuesday a new platform-independent Java ... MOVEit DMZ servers over firewall-friendly HTTPS encrypted connections. , ... for specific platforms, including a Windows API and a ... and secure FTP access. , ,The Java offering is ...
... the Midwest Tel Net consortium have selected Occam ... and high-speed data to the companies' rural residential and ... are Hillsboro Telephone Co. Inc., LaValle Telephone Cooperative and ... was the first local carrier in Wisconsin to ...
... University's new "living laboratory" of teaching technology will ... Madison-based Sonic Foundry, Inc. , to automatically ... company announced Monday. , ,The laboratory, termed the ... with data for making informed investment decisions across ...
Cached Biology Technology:Three Midwest Tel Net members select Occam's platform to increase service 2Ohio State's educational tech lab to use Sonic Foundry system 2
Sheep polyclonal to Salmonella Shoreditch ( Abpromise for all tested applications). Antigen: Native Salmonella shoreditch (Group D2)....
Rabbit polyclonal to ZA20D3 ( Abpromise for all tested applications). entrezGeneID: 54469 SwissProtID: Q6FIF0...
... Rabbit polyclonal to Oct6 ( Abpromise ... Synthetic peptide conjugated to KLH derived from ... (Note: the amino acid sequence is proprietary) ... .) Entrez Gene ID: ...
ATP-binding cassette sub-family D member 4 (Peroxisomal membrane protein 69) (PMP69) (Peroxisomal membrane protein 1-like) (PXMP1-L) (P70R). [Source:Uniprot/SWISSPROT;Acc:O14678] Antigen: Recombi...
Biology Products: