Navigation Links
How mitochondria get their membranes bent
Date:6/24/2009

This release is available in German.

Mitochondria are the powerhouses of cells. Underneath their smooth surface they harbor an elaborately folded inner membrane. It holds a multitude of bottleneck like invaginations, which expand into elongated cavities (cristae). The narrow shape of the entrance or pore to the cristae ('crista junction') allows separation of the intracristal space and storage of molecules. Cytochrome c, for example, an important signaling protein in programmed cell death (apoptosis), is stored in this compartment. When apoptosis is triggered, the pores enlarge and cytochrome c is released into the cytosol. Thus, understanding of how the pore diameter and the shape of the inner membrane are regulated on a molecular basis is of great relevance to a better understanding of mitochondrial function in general. Recently, in cooperation with other research teams, the group of Prof. Andreas Reichert, who has been appointed as professor for Mitochondrial Biology to the Goethe University within the Cluster of Excellence Macromolecular Complexes in 2007, has identified two proteins linked in an antagonistic manner that are relevant for governing inner membrane structure.

In the current issue of the the Journal of Cell Biology Rabl, Soubannier et al. report on their quest of slow-growing baker`s yeast mutants harboring deformed mitochondria. Thereby, they discovered the protein Fcj1 ("Formation of criasta junction protein 1"), which is embedded in the inner membrane and accumulates at crista junctions. Upon increased expression of Fcj1 the number of cristae junctions goes up. Without the protein, however, crista junctions are lacking and the inner cristae membrane forms internal parallel stacks of vesicles.

On the other hand, the researchers found that regular assemblies (supercomplexes) of the F1FO-ATPase, a protein complex required for supplying the cell's energy, accumulated at the cristae tips but were less abundant at crista junctions. In addition, Fcj1 and the F1FO-ATPase appear to have opposing functions. In fact, Fcj1 reduces the formation of F1FO-supercomplexes. "We hypothesize, Fcj1 makes sure that the membrane can adopt a negative curvature, while the F1FO-ATPase supercomplex induces positive bending", Andreas Reichert interprets the results. "This is highly exciting, as we have for the first time found out how mitochondrial ultrastructure is regulated and which components determine the structure of crista junctions at all."


'/>"/>

Contact: Dr. Andreas Reichert
reichert@zbc.kgu.de
49-696-301-87135
Goethe University Frankfurt
Source:Eurekalert

Related biology news :

1. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
2. Zebrafish to shed light on human mitochondrial diseases
3. New chemical tool kit manipulates mitochondria, reveals insights into drug toxicity
4. Mitochondrial dysfunction and redox signaling in atrial tachyarrhythmia
5. Hebrew University develops novel approach for treating mitochondrial disorders
6. Mitochondrial cholesterol makes response to chemotherapy difficult in hepatic cancer
7. Large reservoir of mitochondrial DNA mutations identified in humans
8. A link between mitochondria and tumor formation in stem cells
9. Mitochondria could be a target for therapeutic strategy for Alzheimers disease patients
10. Protein regulates movement of mitochondria in brain cells
11. ESF EURYI award winner aims to stop cancer cells reading their own DNA
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2017)... PUNE, India , March 28, 2017 ... (Analog, IP, Biometrics), Hardware (Camera, Monitors, Servers, Storage Devices), ... Maintenance), Vertical, and Region - Global Forecast to 2022", ... 30.37 Billion in 2016 and is projected to reach ... 15.4% between 2017 and 2022. The base year considered ...
(Date:3/24/2017)... -- The Controller General of Immigration from Maldives Mr. ... have received the prestigious international IAIR Award for the most innovative high ... ... Maldives Immigration Controller ... (small picture on the right) have received the IAIR award for the ...
(Date:3/23/2017)... , March 23, 2017 The report "Gesture Recognition ... Biometric), Industry, and Geography - Global Forecast to 2022", published by MarketsandMarkets, the ... a CAGR of 29.63% between 2017 and 2022. ... ... ...
Breaking Biology News(10 mins):
(Date:4/27/2017)... ... 27, 2017 , ... During the course of this webinar, ... 1,25-Dihydroxyvitamin D can enhance clinical practice. Participants will learn the medical indications and ... Dr. Gregory Plotnikoff, senior consultant with Minnesota Personalized Medicine, will be the speaker ...
(Date:4/27/2017)... , ... April 27, 2017 , ... ... 2017 Borlaug CAST Communication Award goes to Jayson Lusk, a consummate communicator who ... of media to advocate for science, as he explains how innovation and growth ...
(Date:4/26/2017)... ... April 26, 2017 , ... WonderWorks, Myrtle Beach’s science focused ... future of deep space exploration and inspire space enthusiasts. The exhibit features interactive ... a guest appearance by former Shuttle Astronaut Don Thomas. , The intergalactic weekend ...
(Date:4/26/2017)... (PRWEB) , ... April 26, 2017 , ... ... in EMEA and North America this May on the ... 16-18 , Donald H. Taylor, Chairman of the Learning and Performance Institute will ...
Breaking Biology Technology: