Navigation Links
How many nanoparticles heat the tumor?
Date:8/9/2010

This release is available in German.

Those who have to fight a powerful enemy must look for allies. This is why physicists from different scientific fields have decided to cooperate with biomedical physicians in order to place the fight against cancer through heat treatment by means of magnetic nanoparticles on a solid, scientific basis. It is the objective of the cooperation to improve the success of the therapy. Within the scope of a joint project funded by the Deutsche Forschungsgemeinschaft, Melanie Kettering from the Institut fr Diagnostische und Interventionelle Radiologie (IDIR), University Hospital Jena, and Heike Richter from the Physikalisch-Technische Bundesanstalt (PTB) are responsible for the task of detecting where many magnetic nanoparticles can be found in the body of the patient. They are injected into the tumour - but do they really remain there or are they distributed throughout the body? Knowing how many are in the tumour is important for the success of the heat treatment. Now the scientists have been able to successfully demonstrate on mice that magnetic relaxometry is suited to be applied together with the heat treatment. It furnishes information about the whereabouts of the nanoparticles in the body completely without contact to the patient.

For cancer therapy by means of heat treatment, magnetic nanoparticles are injected into the tumour and excited by an external electromagnetic a.c. field. Through this, the magnetic nanoparticles generate heat inside the tumour. If temperatures between 55 C and 60 C are reached, cancer cells can be destroyed irreversibly. The surrounding healthy tissue (without magnetic nanoparticles) remains unaffected. The procedure has not yet found its way into clinical routine, but is still in the trial phase, as a series of questions still have to be clarified. Among other things, a procedure is required which shows where the nanoparticles are located in the body and in which quantity they can be found there. On this basis, a selective treatment of the tumour can be achieved. PTB scientists have found out that magnetic relaxometry is very well suited to obtain this information without even touching the body of the patient or harming her/him in another way.

This is done as follows before the treatment as such is started: The ferric oxide nanoparticles injected into the tumour are superparamagnetic, i.e. they are small magnetic particles which can change their magnetization direction independently of one another. At room temperature, their orientation in the room is statistically distributed so that their sum does not form a magnetic moment. If an external constant magnetic field is now applied, they all orientate themselves almost identically in the room along the field and generate a magnetic moment which can be measured from the outside. This magnetic field is then switched off and with sensitive magnetic field sensors, so-called SQUIDs (Superconducting QUantum Interference Devices, superconducting quantum interference units), the following relaxation of the magnetization - i.e. the return of the magnetic moment from the uniform orientation towards a state with a statistic distribution - is determined extremely promptly. The amplitude of the relaxation signal then provides information about the particle quantity.

The investigations carried out so far on mice allow the conclusion to be drawn that the injection of magnetic nanoparticles and the whereabouts of the particles at the place of injection work variably well. In some tumours, the scientists could find - 24 hours after the injection - the almost complete amount of nanoparticles in the cancer, whereas in other tumours only one quarter of the injected particles could be detected. Up to now, it has not been possible to find a well-founded explanation for these different quantities of magnetic nanoparticles in the tumour. However, the result shows all the more how important it is to apply magnetic relaxometry concurrently with the heat treatment of cancer by nanoparticles to be able to make statements about the quantity of particles in the tumour. (ptb/if)


'/>"/>

Contact: Dr. Heike Richter
heike.richter@ptb.de
49-030-348-17736
Physikalisch-Technische Bundesanstalt (PTB)
Source:Eurekalert

Related biology news :

1. NIST nanofluidic multi-tool separates and sizes nanoparticles
2. New catalyst of platinum nanoparticles could lead to conk-out free, stable fuel cells
3. Nanoblasts from laser-activated nanoparticles move molecules, proteins and DNA into cells
4. Researchers use nanoparticles as destructive beacons to zap tumors
5. K-State researchers find gene-silencing nanoparticles may put end to pesky summer pest
6. Researchers use nanoparticles to shrink tumors in mice
7. Researchers develop drug delivery system using nanoparticles triggered by electromagnetic field
8. Evidence that nanoparticles in sunscreens could be toxic if accidentally eaten
9. NIST scientists gain new core understanding of nanoparticles
10. Antibacterial silver nanoparticles are a blast
11. U Alberta-led team studies T cell activation with nanoparticles
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/13/2017)... April 13, 2017 UBM,s Advanced Design and ... will feature emerging and evolving technology through its 3D ... will run alongside the expo portion of the event ... and demonstrations focused on trending topics within 3D printing ... and manufacturing event will take place June 13-15, 2017 at ...
(Date:4/11/2017)... GARDENS, Fla. , April 11, 2017 /PRNewswire/ ... management and secure authentication solutions, today announced that ... by Intelligence Advanced Research Projects Activity (IARPA) to ... IARPA,s Thor program. "Innovation has been ... and IARPA,s Thor program will allow us to ...
(Date:4/11/2017)... 11, 2017 No two people are ... the New York University Tandon School of Engineering ... found that partial similarities between prints are common ... mobile phones and other electronic devices can be ... vulnerability lies in the fact that fingerprint-based authentication ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... 2017 , ... ComplianceOnline’s Medical Device Summit is back for its 4th year. ... San Francisco, CA. The Summit brings together current and former FDA office bearers, regulators, ... government officials from around the world to address key issues in device compliance, quality ...
(Date:10/11/2017)... TX (PRWEB) , ... October 11, 2017 , ... ... August compared the implantation and pregnancy rates in frozen and fresh in ... contribution of progesterone and maternal age to IVF success. , After comparing the ...
(Date:10/10/2017)... California (PRWEB) , ... October 10, 2017 , ... Dr. ... speaking at his local San Diego Rotary Club. The event entitled ... Diego, CA and had 300+ attendees. Dr. Harman, DVM, MPVM was joined by ...
(Date:10/9/2017)... 2017  BioTech Holdings announced today identification and ... ProCell stem cell therapy prevents limb loss in ... demonstrated that treatment with ProCell resulted in more ... compared to standard bone marrow stem cell administration.  ... reduction of therapeutic effect.  ...
Breaking Biology Technology: