Navigation Links
How many nanoparticles heat the tumor?
Date:8/9/2010

This release is available in German.

Those who have to fight a powerful enemy must look for allies. This is why physicists from different scientific fields have decided to cooperate with biomedical physicians in order to place the fight against cancer through heat treatment by means of magnetic nanoparticles on a solid, scientific basis. It is the objective of the cooperation to improve the success of the therapy. Within the scope of a joint project funded by the Deutsche Forschungsgemeinschaft, Melanie Kettering from the Institut fr Diagnostische und Interventionelle Radiologie (IDIR), University Hospital Jena, and Heike Richter from the Physikalisch-Technische Bundesanstalt (PTB) are responsible for the task of detecting where many magnetic nanoparticles can be found in the body of the patient. They are injected into the tumour - but do they really remain there or are they distributed throughout the body? Knowing how many are in the tumour is important for the success of the heat treatment. Now the scientists have been able to successfully demonstrate on mice that magnetic relaxometry is suited to be applied together with the heat treatment. It furnishes information about the whereabouts of the nanoparticles in the body completely without contact to the patient.

For cancer therapy by means of heat treatment, magnetic nanoparticles are injected into the tumour and excited by an external electromagnetic a.c. field. Through this, the magnetic nanoparticles generate heat inside the tumour. If temperatures between 55 C and 60 C are reached, cancer cells can be destroyed irreversibly. The surrounding healthy tissue (without magnetic nanoparticles) remains unaffected. The procedure has not yet found its way into clinical routine, but is still in the trial phase, as a series of questions still have to be clarified. Among other things, a procedure is required which shows where the nanoparticles are located in the body and in which quantity they can be found there. On this basis, a selective treatment of the tumour can be achieved. PTB scientists have found out that magnetic relaxometry is very well suited to obtain this information without even touching the body of the patient or harming her/him in another way.

This is done as follows before the treatment as such is started: The ferric oxide nanoparticles injected into the tumour are superparamagnetic, i.e. they are small magnetic particles which can change their magnetization direction independently of one another. At room temperature, their orientation in the room is statistically distributed so that their sum does not form a magnetic moment. If an external constant magnetic field is now applied, they all orientate themselves almost identically in the room along the field and generate a magnetic moment which can be measured from the outside. This magnetic field is then switched off and with sensitive magnetic field sensors, so-called SQUIDs (Superconducting QUantum Interference Devices, superconducting quantum interference units), the following relaxation of the magnetization - i.e. the return of the magnetic moment from the uniform orientation towards a state with a statistic distribution - is determined extremely promptly. The amplitude of the relaxation signal then provides information about the particle quantity.

The investigations carried out so far on mice allow the conclusion to be drawn that the injection of magnetic nanoparticles and the whereabouts of the particles at the place of injection work variably well. In some tumours, the scientists could find - 24 hours after the injection - the almost complete amount of nanoparticles in the cancer, whereas in other tumours only one quarter of the injected particles could be detected. Up to now, it has not been possible to find a well-founded explanation for these different quantities of magnetic nanoparticles in the tumour. However, the result shows all the more how important it is to apply magnetic relaxometry concurrently with the heat treatment of cancer by nanoparticles to be able to make statements about the quantity of particles in the tumour. (ptb/if)


'/>"/>

Contact: Dr. Heike Richter
heike.richter@ptb.de
49-030-348-17736
Physikalisch-Technische Bundesanstalt (PTB)
Source:Eurekalert

Related biology news :

1. NIST nanofluidic multi-tool separates and sizes nanoparticles
2. New catalyst of platinum nanoparticles could lead to conk-out free, stable fuel cells
3. Nanoblasts from laser-activated nanoparticles move molecules, proteins and DNA into cells
4. Researchers use nanoparticles as destructive beacons to zap tumors
5. K-State researchers find gene-silencing nanoparticles may put end to pesky summer pest
6. Researchers use nanoparticles to shrink tumors in mice
7. Researchers develop drug delivery system using nanoparticles triggered by electromagnetic field
8. Evidence that nanoparticles in sunscreens could be toxic if accidentally eaten
9. NIST scientists gain new core understanding of nanoparticles
10. Antibacterial silver nanoparticles are a blast
11. U Alberta-led team studies T cell activation with nanoparticles
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2016)... May 24, 2016 Ampronix facilitates superior patient care by providing unparalleled technology ... LCD display is the latest premium product recently added to the range of products ... ... ... 3d Imaging- LCD Medical Display- Ampronix News ...
(Date:5/3/2016)... , May 3, 2016  Neurotechnology, a ... the MegaMatcher Automated Biometric Identification System (ABIS) ... large-scale multi-biometric projects. MegaMatcher ABIS can process multiple ... using any combination of fingerprint, face or iris ... MegaMatcher SDK and MegaMatcher Accelerator , ...
(Date:4/19/2016)... UAE, April 20, 2016 The ... as a compact web-based "all-in-one" system solution for all ... fingerprint reader or the door interface with integration authorization ... access control systems. The minimal dimensions of the access ... into the building installations offer considerable freedom of design ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... , June 27, 2016 /PRNewswire/ - BIOREM Inc. (TSX-V: BRM) ... advised by its major shareholders, Clean Technology Fund I, ... United States based venture capital funds which ... Biorem (on a fully diluted, as converted basis), that ... of their entire equity holdings in Biorem to TUS ...
(Date:6/27/2016)... ... June 27, 2016 , ... ... will join the faculty of the University of North Carolina Kenan-Flagler Business ... strategy and entrepreneurship at UNC Kenan-Flagler, with a focus on the school’s international ...
(Date:6/24/2016)... ... June 24, 2016 , ... While the majority of commercial ... Cary 5000 and the 6000i models are higher end machines that use the more ... the spectrophotometer’s light beam from the bottom of the cuvette holder. , FireflySci ...
(Date:6/23/2016)... , June 23, 2016 /PRNewswire/ - FACIT has ... Ontario biotechnology company, Propellon Therapeutics Inc. ... and commercialization of a portfolio of first-in-class WDR5 ... targets such as WDR5 represent an exciting class ... in precision medicine for cancer patients. Substantial advances ...
Breaking Biology Technology: