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How long do stem cells live?
Date:3/1/2011

LA JOLLA, Calif., March 1, 2011 When patients receive a bone marrow transplant, they are getting a new population of hematopoietic stem cells. Fresh stem cells are needed when a patient is low on red blood cells, as in anemia, or white blood cells, which can be caused by cancer or even cancer treatments such as irradiation or chemotherapy. The problem is that a bone marrow transplant might not succeed because the transplanted stem cells don't live long enough or because they proliferate too well, leading to leukemia.

To help determine how long a bone marrow (stem cell) graft will last, researchers at Sanford-Burnham Medical Research Institute (Sanford-Burnham) have developed a mathematical model that predicts how long a stem cell will live and tested those predictions in a mouse model. The study, led by Christa Muller-Sieburg, Dr. rer. nat., was published online the week of February 28, in the journal Proceedings of the National Academy of Sciences.

"It has long been assumed that stem cells are immortal they continue to self-renew, thus generating more stem cells that collectively can outlast an individual's life," said Dr. Muller-Sieburg, professor in Sanford-Burnham's Stem Cells and Regenerative Biology Program. "But now we have found that each stem cell is pre-programmed to self-renew only for a set amount of time that, in mice, ranges from a few months to several years. So we created a computer program that predicts that lifespan."

Researchers drew blood from transplant recipients, took a few initial measurements of the mature white blood cells generated from the transplant, and entered those parameters into a computer program that predicts their lifespan. This information was then compared to the stem cells' true lifespan. Some stem cells lasted five months and others more than three years, but again and again the computer program predicted survival time with surprising accuracy.

Dr. Muller-Sieburg and her
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Contact: Josh Baxt
jbaxt@sanfordburnham.org
858-795-5236
Sanford-Burnham Medical Research Institute
Source:Eurekalert

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