Navigation Links
How kids' brain structures grow as memory develops
Date:4/16/2014

Our ability to store memories improves during childhood, associated with structural changes in the hippocampus and its connections with prefrontal and parietal cortices. New research from UC Davis is exploring how these brain regions develop at this crucial time. Eventually, that could give insights into disorders that typically emerge in the transition into and during adolescence and affect memory, such as schizophrenia and depression.

Located deep in the middle of the brain, the hippocampus plays a key role in forming memories. It looks something like two curving fingers branching forward from a common root. Each branch is a folded-over structure, with distinct areas in the upper and lower fold.

"For a long time it was assumed that the hippocampus didn't develop at all after the first couple of years of life," said Joshua Lee, a graduate student at the UC Davis Department of Psychology and Center for Mind and Brain. Improvements in memory were thought to be due entirely to changes in the brain's outer layers, or cortex, that manage attention and stretagies. But that picture has begun to change in the past five years.

Recently, Lee, Professor Simona Ghetti at the Center for Mind and Brain and Arne Ekstrom, assistant professor in the UC Davis Center for Neuroscience, used magnetic resonance imaging to map the hippocampus in 39 children aged eight to 14 years.

While subfields of the hippocampus have been mapped in adult humans and animal studies, it's the first time that they have been measured in children, Ghetti said.

"This is really important to us, because it allows us to understand the heterogeneity along the hippocampus, which has been examined in human adults and other species" Ghetti said.

Looking at three subregions the cornu ammonis (CA) 1, CA3/dentate gyrus and subiculum they found that the first two expanded with age, with the most pronounced growth in the right hippocampus. Only in the oldest 25 percent of the children, within a few months either side of 14, did the sizes of all three regions decrease.

When they tested the children for memory performance, children with a larger CA3/dentate gyrus tended to perform better, they found. The work was published online March 15 by the journal Neuroimage.

In a related study in collaboration with the laboratory of Professor Silvia Bunge at UC Berkeley, published March 27 in Cerebral Cortex, the researchers also demonstrated how white matter connections projecting from the hippocampus to the brain cortex are related to memory function in children.

"White matter" tracts connect the prefrontal and parietal regions of the brain cortex, which control how we pay attention to things and engage in memory strategies, with the media-temporal lobe, the area that includes the hippocampus.

In the study, children performed a memory test that prompted them either to actively memorize an item and therefore engage the prefrontal and parietal cortices or to view an image passively. The ability to successfully modulate attention was linked to development of white matter tracts linking the prefrontal and parietal cortex tothe mediatemporal lobe, Ghetti said, but not to fronto-parietal connections.

Lead author on the paper is UC Berkeley researcher Carter Wendelken, with coauthors Lee, Bunge and Ghetti as well as Jacqueline Pospisil, Marcos Sastre and Julia Ross, all at UC Davis. It's part of a large collaborative study of memory function and brain growth in children, lead by Ghetti and Bunge, and funded by the National Institutes of Health. The study will look at the development of in a cohort of children from age eight to 14 years.


'/>"/>

Contact: Andy Fell
ahfell@ucdavis.edu
530-752-4533
University of California - Davis
Source:Eurekalert  

Related biology news :

1. Kids and insect scientists to meet in San Antonio
2. Decriminalizing pot may land more kids in the ER
3. TV ads nutritionally unhealthy for kids, study finds
4. Large dishes increase how much cereal kids request, eat, and waste
5. Gut microbes in healthy kids carry antibiotic resistance genes
6. Schools help kids choose carrots over candy bars
7. Kids born small should get moving
8. Taste rules for kids and healthy food choices
9. Obese dads pass on predisposition to obesity and metabolic disorders to their kids
10. Magnesium may be as important to kids bone health as calcium
11. CU-Boulder study looks at microbial differences between parents, kids and dogs
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
How kids' brain structures grow as memory develops
(Date:2/1/2017)... BOSTON, Massachusetts , February 1, 2017 ... and events on emerging technology, announces the availability of a new ... Continue Reading ... ... systems in industrial and collaborative robots. Source: IDTechEx Report "Sensors for ...
(Date:1/30/2017)... --  Invitae Corporation (NYSE: NVTA ), ... announced that it will report its fourth quarter and ... Monday, February 13, 2017, and Invitae,s management team will ... Eastern / 1:45 p.m. Pacific. During ... results, guidance, and recent developments and will spend the ...
(Date:1/26/2017)... DENVER , Jan. 26, 2017  Acuity ... Trends for Biometrics and Digital Identity".  Acuity characterizes ... digital identity when increased adoption reflects a new ... "Biometrics and digital identity are ... says Maxine Most , Principal of Acuity ...
Breaking Biology News(10 mins):
(Date:2/22/2017)... ... February 22, 2017 , ... ... addition of Tom Perkins as European director. Operating from Pennside’s Zurich headquarters, Pennside ... , Perkins joins Pennside after more than a decade with leading market ...
(Date:2/22/2017)... N.C., Feb. 22, 2017  United Therapeutics Corporation (NASDAQ: ... results for the fourth quarter and year ended ... results reflect continued growth as net revenues reached ... Martine Rothblatt, Ph.D., United Therapeutics, Chairman and Chief ... to develop and advance our growing product pipeline, ...
(Date:2/21/2017)... Feb. 21, 2017 /PRNewswire/ - SQI Diagnostics Inc. ("SQI" or the ... results for the three months ended December 31, 2016. ... life sciences and diagnostics company that develops and commercializes proprietary ... ... build on the commercial milestones achieved in fiscal 2016," said ...
(Date:2/21/2017)... ... February 21, 2017 , ... ... Liquid Biopsy System , a fully automated benchtop system for collecting intact circulating ... is being launched at the Molecular Medicine Tri Conference (Tri-Con) Annual Meeting 2017 ...
Breaking Biology Technology: