Navigation Links
How immune cells use steroids
Date:5/8/2014

Hinxton, 8 May 2014 Researchers at the European Bioinformatics Institute (EMBL-EBI) and the Wellcome Trust Sanger Institute have discovered that some immune cells turn themselves off by producing a steroid. The findings, published in Cell Reports, have implications for the study of cancers, autoimmune diseases and parasitic infections.

If you've ever used a steroid, for example cortisone cream on eczema, you'll have seen first-hand how efficient steroids are at suppressing the immune response. Normally, when your body senses that immune cells have finished their job, it produces steroids but which cells actually do that?

In this latest study, scientists looked at Th2 immune cells during parasitic infection and saw that at a certain point, these cells produce a steroid called pregnenolone.

"We were really surprised to see that these immune cells are producing a steroid. In cell culture, we see that the steroids play a part in regulating T cell proliferation," says Bidesh Mahata in the Teichmann group at EMBL-EBI and Sanger, who designed the study. "We had already seen that T-helper cells were producing steroids, but initially we were blind what was going on?"

"Because we had access to data from single-cell sequencing experiments, we could conduct deep statistical analyses on a very large and comprehensive dataset," explains Sarah. "That pointed us to the genes involved in pregnenolone production at the point when Th2 cells are being produced, and we could deduce that the Th2 cells themselves were involved in immunosuppression."

The researchers suggest that bringing the immune system back into balance is an intrinsic part of this particular immune response.

"We confirmed our findings experimentally, showing that pregnenolone inhibits both Th cell proliferation and B cell immunoglobulin class switching," adds Bidesh. "We think this points to the idea that Th2 cells differentiate into steroid-producing cells as part of a larger mechanism to bring the immune system back into balance."


'/>"/>

Contact: Sonia Furtado Neves
pressoffice@embl.de
49-622-138-78263
European Molecular Biology Laboratory
Source:Eurekalert  

Related biology news :

1. Immune cells outsmart bacterial infection by dying, Penn Vet study shows
2. New experimental vaccine produces immune response against MERS virus
3. Low cholesterol in immune cells tied to slow progression of HIV
4. Low cholesterol in immune cells slows HIV progression
5. For an immune cell, microgravity mimics aging
6. Some immune cells defend only 1 organ
7. New method isolates immune cells for researchers to study how they ward off oral diseases
8. Sensitive balance in the immune system
9. La Jolla Institute discovers new mechanism for unleashing immune system against cancer
10. Immune cell defenders could beat invading bacteria
11. Newly discovered molecule may offer hope for immune disorders and runaway inflammation
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
How immune cells use steroids
(Date:4/11/2017)... , April 11, 2017 No ... but researchers at the New York University Tandon ... of Engineering have found that partial similarities between ... systems used in mobile phones and other electronic ... The vulnerability lies in the fact ...
(Date:4/5/2017)... LONDON , April 4, 2017 KEY ... is anticipated to expand at a CAGR of 25.76% ... neurodegenerative diseases is the primary factor for the growth ... full report: https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The ... of product, technology, application, and geography. The stem cell ...
(Date:3/30/2017)... Trends, opportunities and forecast in this market ... (fingerprint, AFIS, iris recognition, facial recognition, hand geometry, vein ... use industry (government and law enforcement, commercial and retail, ... others), and by region ( North America ... Pacific , and the Rest of the World) ...
Breaking Biology News(10 mins):
(Date:6/20/2017)... ... June 20, 2017 , ... ... determine the adulterants which pose the most likely threat to their products at ... this year. , IFT's annual food expo attracts over 20,000 attendees representing ...
(Date:6/20/2017)... ... June 20, 2017 , ... GigaGen Inc ., a ... repertoires, announces launch of its new Surge(TM) Discovery service at the ... GigaGen, will present on Surge at the conference. , Surge is the new, ...
(Date:6/19/2017)... ... ... A colony of healthy honey bees is like a superorganism--individual bees provide ... containing nutrients necessary for growth and survival. Better nutrition gives the colony a strong ... a decline in honey bee health. Sick and weakened bees diminish the colony's resiliency, ...
(Date:6/15/2017)... ... 2017 , ... New resistant soybean and cotton cropping systems ... amaranth and other broadleaf weeds resistant to glyphosate. But scientists with the Weed ... known to drift and to cause harm to sensitive, off-target broadleaf plants. , ...
Breaking Biology Technology: