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How 'hidden mutations' contribute to HIV drug resistance
Date:7/31/2008

is colleagues selected a few of these previously uncharacterized mutations and subjected them to a battery of highly sensitive biochemical tests.

"People were skeptical," Dr. Gtte said. "The mechanism about how these mutations could be involved in resistance was not clear. However, in our paper, we present data that explains in considerable detail how these mutations work."

Nevertheless, he cautioned, the debate about whether to routinely screen these areas of the HIV genome will still likely continue for some time.

"It's extremely time-consuming and expensive to validate genotype testing," he said. "However, we probably will be testing these areas in a couple of years."


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Contact: Mark Shainblum
mark.shainblum@mcgill.ca
514-398-2189
McGill University
Source:Eurekalert

Page: 1 2

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