Navigation Links
How 'hidden mutations' contribute to HIV drug resistance
Date:7/31/2008

This press release is available in French.

One of the major reasons that treatment for HIV/AIDS often doesn't work as well as it should is resistance to the drugs involved. Now, scientists at McGill University have revealed how mutations hidden in previously ignored parts of the HIV genome play an important role in the development of drug resistance in AIDS patients. Their study will be published Aug. 8 in the Journal of Biological Chemistry.

"HIV develops resistance very rapidly, and once that happens, drugs don't work as well as they theoretically should, or they stop working altogether," explained Dr. Matthias Gtte, an associate professor in McGill's Department of Microbiology and Immunology. "Physicians routinely have the patient's virus tested for resistance in advance of treatment to help make the appropriate clinical decisions."

The study was conducted by a team of researchers led by Dr. Gtte at McGill's Faculty of Medicine, with assistance from the B.C. Centre for Excellence in HIV/AIDS at the University of British Columbia (UBC). It was funded by the Canadian Institutes for Health Research (CIHR).

HIV genotype testing is now widely established in HIV drug resistance screening. However, for technical and economic reasons, the entire HIV genome is usually not sequenced.

"The focus has been on specific areas of the HIV genome where we expect these resistance-conferring mutations to occur," Dr. Gtte said. "We focus on a particular sequence on an important gene from amino acid 1 to 300, and as such, we miss roughly a third of this gene. Until recently, most researchers believed that this hidden area was of little clinical significance."

Within the last few years, however, studies started to suggest that the first 300 amino acids alone may not completely describe the drug resistance landscape. Dr. Gtte and h
'/>"/>

Contact: Mark Shainblum
mark.shainblum@mcgill.ca
514-398-2189
McGill University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers reveal insights into hidden world of protein folding
2. Using ground-penetrating radar to observe hidden underground water processes
3. Exploration of lake hidden beneath Antarcticas ice sheet begins
4. New plant study reveals a deeply hidden layer of the transcriptome
5. Poor Americans in the United States suffer hidden burden of parasitic and other neglected diseases
6. Stanford/Packard researchers find disease genes hidden in discarded data
7. UD plant biologists uncover top wetland plants hidden weapon
8. Biologists expose hidden costs of firefly flashes
9. Hidden interactions between predators and prey: evolution causes cryptic dynamics in ecology
10. Smothered genes combine with mutations to yield poor outcome in cancer patients
11. Oocyte-specific gene mutations cause premature ovarian failure
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... Conn. , Dec. 22, 2014  NXT-ID, Inc. (NASDAQ: ... biometric authentication company focused on the growing mobile commerce market, ... Apollo Robbins for the 2015 International CES debut ... Apollo Robbins will be at the NXT-ID booth January ...
(Date:12/19/2014)... 2014 Research and Markets ( http://www.researchandmarkets.com/research/86ncd6/micro_market ) has ... America Perimeter Security Systems Market" report to their offering. ... North American perimeter security market is estimated to grow at ... U.S. market holds a larger share in this market, ...
(Date:12/17/2014)... 15, 2014 The Defense Logistics Agency is insourcing ... prevent counterfeit microcircuits from entering into its supply chain. ... microcircuit anti-counterfeit initiative dubbed DNA marking. The capability will ... reliability throughout the supply chain. The new quality control ...
Breaking Biology News(10 mins):NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 3NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 4Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 3
... is available in Spanish . , Self-pollinating ... pollination are being developed by Agricultural Research Service (ARS) scientists. ... costs for insect pollination because of nationwide shortages of honeybees ... ARS geneticist Craig Ledbetter, at the agency,s Crop Diseases, ...
... DURHAM, N.C. A new study reconstructing thousands of ... use of prescribed fire, or controlled burns, as a tool ... health and protect rare ecological communities in the region,s forests. ... soil charcoal samples dating from 1977 to more than 4,000 ...
... research by a team of ecologists and hydrologists shows ... rivers throughout the United States. The research, published in ... , documents that 20 major U.S. streams and rivers ... Delaware, and Hudson have shown statistically significant long-term ...
Cached Biology News:ARS scientists develop self-pollinating almond trees 24,000-year study supports use of prescribed burns in Southern Appalachians 24,000-year study supports use of prescribed burns in Southern Appalachians 3New study shows rising water temperatures in US streams and rivers 2
(Date:12/24/2014)... Earlier this year in a June 24 international conference presentation, ... Technology Center, LLC ( ASCTC ) focused attention on an ... stem cells. His title “Asymmetric Self-Renewal by Distributed Stem ... the essence of his message to congress participants. He ...
(Date:12/24/2014)... 2014 On Friday, December 19, 2014, ... and Continuing Resolution Appropriations Act of 2015, which for ... receive funding through the Congressionally Directed Medical Research Programs ... Hydrocephalus Association (HA), working in conjunction with its allies ...
(Date:12/24/2014)... 2014 The report provides basic ... classification, application and industry overview. This report also ... structure. Production is separated by regions, technology and ... equipment, downstream client survey, marketing channels, industry development ...
(Date:12/24/2014)... 2014 The report expects global cell isolation ... also provides a carefully analyzed data about the vital drivers, ... Full Copy of Report @ http://bit.ly/1yUxy0T , According ... keep witnessing growth at an impressive CAGR during near future. ...
Breaking Biology Technology:Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 2Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 3Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 4Rare Brain Condition Now Eligible for Department of Defense Research Dollars 2Worldwide Methyl Mercaptan Market 2015-2020 Forecasts on Development & Trends Now Available at ReportsnReports.com 2The Cell Expansion Market is Expected to Reach $14.8 billion by 2019 - New Research Report by MarketsandMarkets 2The Cell Expansion Market is Expected to Reach $14.8 billion by 2019 - New Research Report by MarketsandMarkets 3
... 21, 2011 Peter M. DeComo, Chairman of the ... (PLSG), the organization providing capital investments and customized company ... sciences enterprises, today congratulated John W. Manzetti and the ... 2011 Outstanding Leadership in Technology category winner at ...
... Corp. (OTC Bulletin Board: CPHB ), a ... has signed a exclusive worldwide license agreement with the ... and market a universal donor blood product derived from ... Medicine and Pediatrics Dr. Ewa Carrier. The red blood ...
... JERSEY CITY, N.J., March 21, 2011 Intrasphere ... consulting and solutions firm that provides services to ... launched SafetyXpress. SafetyXpress for Argus is Intrasphere,s proprietary ... the Argus Safety suite. Intrasphere is a Specialized ...
Cached Biology Technology:John W. Manzetti and the Pittsburgh Life Sciences Greenhouse Recognized as 2011 Outstanding Leader in Technology 2China PharmaHub In-Licenses Universal Donor Red Blood Cells Technology Exclusively From University of California, San Diego 2Intrasphere Technologies Launches SafetyXpress(TM) for Oracle(R) Argus Safety 2
... Power Supply, 1. 300 V, 400 ... constant current modes.Single-unit increments in settings ... for submarine, mini vertical, and standard ... semidry and mini tank blotting applications. ...
... EPS 1001 Power Supply, 1. 1000 ... voltage, constant current, and constant power ... for precision and reproducibility.Stores and recalls ... flatbed gels on Multiphor II ...
Mouse TrkC Affinity Purified Polyclonal Ab...
Immunogen: Full length M32 fusion protein. Storage: -20 C, Avoid Freeze/Thaw Cycles...
Biology Products: