Navigation Links
How good cholesterol turns bad
Date:2/21/2012

Researchers with the U.S. Department of Energy (DOE)'s Lawrence Berkeley National Laboratory (Berkeley Lab) have found new evidence to explain how cholesteryl ester transfer protein (CETP) mediates the transfer of cholesterol from "good" high density lipoproteins (HDLs) to "bad" low density lipoproteins (LDLs). These findings point the way to the design of safer, more effective next generation CETP inhibitors that could help prevent the development of heart disease.

Gang Ren, a materials physicist and electron microscopy expert with Berkeley Lab's Molecular Foundry, a DOE nanoscience research center, led a study in which the first structural images of CETP interacting with HDLs and LDLs were recorded. The images and structural analyses support the hypothesis that cholesterol is transferred from HDLs to LDLs via a tunnel running through the center of the CETP molecule.

"Our images show that CETP is a small (53 kilodaltons) banana-shaped asymmetric molecule with a tapered N-terminal domain and a globular C-terminal domain," Ren says. "We discovered that the CETP's N-terminal penetrates HDL and its C-terminal interacts with LDL forming a ternary complex. Structure analyses lead us to hypothesize that the interaction may generate molecular forces that twist the terminals, creating pores at both ends of the CETP. These pores connect with central cavities in the CETP to form a tunnel that serves as a conduit for the movement of cholesterol from the HDL."

Ren reports the results of this study in a paper in the journal Nature Chemical Biology titled "Structure basis of transfer between lipoproteins by cholesteryl ester transfer protein." Co-authoring this paper were Lei Zhang, Feng Yan, Shengli Zhang, Dongsheng Lei, M. Arthur Charles, Giorgio Cavigiolio, Michael Oda, Ronald Krauss, Karl Weisgraber, Kerry-Anne Rye, Henry Powna and Xiayang Qiu.

Cardiovascular or heart disease, mainly atherosclerosis, remains the leading cause of dea
'/>"/>

Contact: Lynn Yarris
lcyarris@lbl.gov
510-486-5375
DOE/Lawrence Berkeley National Laboratory
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Cholesterol-lowering drugs and the effect on muscle repair and regeneration
2. Penn biophysicists create new model for protein-cholesterol interactions in brain and muscle tissue
3. MSU researcher studies ties between cholesterol drugs, muscle problems
4. A scientific breakthrough on the control of the bad cholesterol
5. Researchers learn that some good cholesterol isnt good enough
6. New genes present drug targets for managing cholesterol and glucose levels
7. Hypertension and cholesterol medications present in water released into the St. Lawrence River
8. Lowering your cholesterol may decrease your risk of cancer
9. Cholesterol-busting bug with a taste for waste
10. Cholesterol necessary for brain development
11. UCLA researchers reconstitute enzyme that synthesizes cholesterol drug lovastatin
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
How good cholesterol turns bad
(Date:11/6/2014)... team of Florida State University biologists could lead to ... and survive environmental swings such as droughts or floods. ... the journal The Plant Cell , sheds light ... is organized in a cell and how plants regulate ... and others are turned off. , "If you understand ...
(Date:11/5/2014)... associate professor of biology in the UTSA College ... the nation selected to receive a two-year $300,00 ... Exploratory Research (EAGER). The funding supports President Obama,s ... to create new technology that will demystify complex ... behaviors in neuroscience are broken into the interactions ...
(Date:11/4/2014)... amount of death at the right time might actually ... research that could help in understanding animal populations, pest ... a paper in the journal Trends in Ecology ... colleagues conclude that the kind of positive population effect ... or mortality, depends on the size and developmental stage ...
Breaking Biology News(10 mins):Maize analysis yields whole new world of genetic science 2UTSA biology professor awarded $300,000 NSF grant for brain research 2UTSA biology professor awarded $300,000 NSF grant for brain research 3When less is more: Death in moderation boosts population density in nature 2
... tiny pest threatening the staple diet of millions ... project announced today, bringing together plant experts from ... Dr Peter Urwin from the University of Leeds ... through the 7 million Sustainable Agriculture Research for ...
... is availabe in Spanish . , ANN ... the National Institute on Aging have produced the largest ... a treasure trove offering new insights into early migrations ... astronomers who build ever-larger telescopes to peer deeper into ...
... between two points, but it isnt necessarily the fastest ... when terrain is not level, and now American and ... a zigzag course provides the most efficient way for ... I think zigzagging is something people do intuitively, said ...
Cached Biology News:Purging the plantain pests in Africa 2U-M researchers release most detailed global study of genetic variation 2U-M researchers release most detailed global study of genetic variation 3In the race to the top, zigzagging is more efficient than a straight line 2
(Date:11/21/2014)... The science of light and how ... more than 200 primary students in a traveling program ... of Otago Physics Department and funded by an ... of the university’s OSA/SPIE Student Chapter visited six primary ... children from small, rural schools hands-on lessons in optics ...
(Date:11/21/2014)... York, NY (PRWEB) November 20, 2014 ... is now available as an open access journal featuring ... with infrared fluorescent proteins to preserve photoresponsiveness in the ... Two-color fluorescent in situ hybridization using chromogenic substrates ... chips for DNA, RNA, and protein electrophoresis , ...
(Date:11/21/2014)... 2014 Polaris Group announced today that ... Phase 1 trial of ADI-PEG 20 in combination ... malignant pleural mesothelioma (MPM) and non-squamous non-small cell ... on ADI-PEG 20, both as monotherapy and in ... several other indications, including breast cancer, melanomas, ovarian ...
(Date:11/18/2014)... RPS Diagnostics (RPS®) – a ... announces its third annual partnership of the Centers ... About Antibiotics Week from November 17-23. , Get ... designed to highlight the coordinated efforts of CDC, ... for-profit partners to provide education about the importance ...
Breaking Biology Technology:Optics and photonics outreach programs share science, spark fascination with light 2Optics and photonics outreach programs share science, spark fascination with light 3BioTechniques: The International Journal of Life Science Methods Announces the Publication of the November 2014 Issue—Available in Print and Online 2BioTechniques: The International Journal of Life Science Methods Announces the Publication of the November 2014 Issue—Available in Print and Online 3Polaris Group Announces Treatment of First Patient in Phase 1 Study of ADI-PEG 20 plus Pemetrexed and Cisplatin in Malignant Pleural Mesothelioma And Non-Squamous Non-Small Cell Lung Carcinoma 2RPS Again Partners with the CDC in Support of the 2014 Get Smart About Antibiotics Week 2RPS Again Partners with the CDC in Support of the 2014 Get Smart About Antibiotics Week 3
... 3 /PRNewswire-FirstCall/ - OncoGenex Pharmaceuticals, Inc. (NASDAQ: OGXI ) announced today ... at the 9th Annual Needham Healthcare Conference on June 10 at ... New York City . , , ... webcast will be available through the Investor Relations page of the OncoGenex Web ...
... China , June 3 /PRNewswire-Asia-FirstCall/ -- Tianyin,Pharmaceutical Co., Inc. (NYSE Amex: TPI ), ... at the Company,s website: , , , ... , , ... , , ...
... Caliper Life Sciences, Inc. (Nasdaq: CALP ) today announced that its ... on Friday, June 11 at 12:45 p.m. EDT . ... on the company,s business. The live webcast can be accessed at ... , , ...
Cached Biology Technology:OncoGenex Pharmaceuticals to Present at the 9th Annual Needham Healthcare Conference 2Tianyin Corporate Presentation Updated 2
Porcine Aortic Smooth Muscle Cells (PAOSMC) (>500,000 cells)...
... Monoclonal Anti-β-Tubulin IV Recognizes ... C-terminal sequence of β-tubulin isotype ... tubulin isotypes is observed. ascites ... the C-terminal sequence of β-tubulin ...
Porcine Coronary Artery Smooth Muscle Cells (PCASMC) (>500,000 cells)...
Porcine Aortic Endothelial Cells (PAOEC) (>500,000 cells)...
Biology Products: