Navigation Links
How genetic 'chips' could help to understand heart disease

New research at the University of Leicester will use the latest genetic techniques to examine DNA from over 20,000 patients with heart disease.

The study will help to identify new genes and molecules responsible for Coronary Artery Disease (CAD). This, in turn may help to develop new diagnostic and treatment strategies.

The project is being undertaken by postgraduate researcher Paraskevi Christofidou, of the Department of Cardiovascular Sciences. Preliminary findings from her research will be presented at the University of Leicester on 24 June.

Miss Christofidou said: "Coronary Artery Disease - a disease causing narrowing of arteries in the heart - remains a major cause of death worldwide. Shockingly, in the USA on average one person dies of this disease every 34 seconds. In the UK it causes over 100 000 deaths a year, approximately one in five deaths in men and one in six deaths in women.

"Various risk factors such as high blood pressure, smoking, obesity and increased levels of cholesterol play a significant role in the progression of CAD. There is also evidence that familial predisposition is a strong risk factor. Indeed, your risk of CAD increases by almost 50% if one of your relatives has a history of heart disease. "

Miss Christofidou said a part of this genetic susceptibility to CAD is transmitted from one generation to another as a collection of small changes in DNA sequence called single nucleotide polymorphisms (SNPs).

She added: "The recent genetic revolution offers tracking of SNPs in human DNA on an unprecedented scale. With the use of new genetic tools called "chips" it is possible to track and characterise precisely up to 1 million SNPs in a subject.

"We anticipate that some of these variants occur more frequently in patients with CAD compared to healthy subjects and are responsible for genetic predisposition to CAD. It is likely that some of these variants are rare so large cohorts of subjects are needed to identify sufficient numbers for analysis."

This project will conduct analysis of human DNA from more than 20 000 patients with CAD and 60 000 healthy controls.


Contact: Paraskevi Christofidou
University of Leicester

Related biology news :

1. Does the desire to consume alcohol and tobacco come from our genetic makeup?
2. Diverse genetic abnormalities lead to NF-κB activation in multiple myeloma
3. Many parents at-risk for cancer disclose genetic test results to children
4. Genetics determine optimal drug dose of common anticoagulant
5. Claims of sex-related differences in genetic association studies often not properly validated
6. American College of Medical Genetics responds to new FDA labeling decision for warfarin
7. UNC study questions FDA genetic-screening guidelines for cancer drug
8. Genome study shines light on genetic link to height
9. Selexis Announces Advanced Approach to Maximize Power of Genetic Elements for Rapid Development of High Performance Cell Lines
10. Genes, Environment and Health Initiative invests in genetic studies, environmental monitoring
11. Rutgers Genetics receives $7.8 million for autism research
Post Your Comments:
(Date:11/12/2015)... golden retriever that stayed healthy despite having the gene ... new lead for treating this muscle-wasting disorder, report scientists ... and Harvard and the University of São Paolo in ... pinpoints a protective gene that boosts muscle regeneration, ... Children,s lab of Lou Kunkel , PhD, is ...
(Date:11/12/2015)... Nov. 11, 2015   Growing need for ... tools has been paving the way for use ... of discrete analytes in clinical, agricultural, environmental, food ... predominantly used in medical applications, however, their adoption ... due to continuous emphasis on improving product quality ...
(Date:11/10/2015)... Nov. 10, 2015  In this report, ... basis of product, type, application, disease indication, ... this report are consumables, services, software. The ... safety biomarkers, efficacy biomarkers, and validation biomarkers. ... are diagnostics development, drug discovery and development, ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... and NEW YORK , November 24, ... investment by Bristol-Myers Squibb in a European ... Bristol-Myers Squibb Company in which the companies will work ... immuno-oncology and other areas of unmet medical need. The collaboration ... LSP 5, the latest LSP fund. This is the first ...
(Date:11/23/2015)... CHICAGO , Nov. 24, 2015 Women with ... screening CT exams face a higher risk of lung cancer ... being presented next week at the annual meeting of the ... --> --> Lung ... are classified as solid or subsolid based on their appearance ...
(Date:11/23/2015)... ... 23, 2015 , ... Shimadzu Corporation announces that it has ... Chromatography system. The award from R&D magazine recognizes Shimadzu’s Nexera UC system as ... the analytical and testing category. R&D Magazine chose the Nexera UC system because ...
(Date:11/23/2015)... England and PISCATAWAY, New ... Cambridge Crystallographic Data Centre (CCDC) ... the Cambridge Structural Database (CSD) and the CSD-System, ... for researchers worldwide: CSD-Discovery to support the discovery ... crystalline materials, and CSD-Enterprise, the complete set of ...
Breaking Biology Technology: