Navigation Links
How genetic 'chips' could help to understand heart disease
Date:6/24/2010

New research at the University of Leicester will use the latest genetic techniques to examine DNA from over 20,000 patients with heart disease.

The study will help to identify new genes and molecules responsible for Coronary Artery Disease (CAD). This, in turn may help to develop new diagnostic and treatment strategies.

The project is being undertaken by postgraduate researcher Paraskevi Christofidou, of the Department of Cardiovascular Sciences. Preliminary findings from her research will be presented at the University of Leicester on 24 June.

Miss Christofidou said: "Coronary Artery Disease - a disease causing narrowing of arteries in the heart - remains a major cause of death worldwide. Shockingly, in the USA on average one person dies of this disease every 34 seconds. In the UK it causes over 100 000 deaths a year, approximately one in five deaths in men and one in six deaths in women.

"Various risk factors such as high blood pressure, smoking, obesity and increased levels of cholesterol play a significant role in the progression of CAD. There is also evidence that familial predisposition is a strong risk factor. Indeed, your risk of CAD increases by almost 50% if one of your relatives has a history of heart disease. "

Miss Christofidou said a part of this genetic susceptibility to CAD is transmitted from one generation to another as a collection of small changes in DNA sequence called single nucleotide polymorphisms (SNPs).

She added: "The recent genetic revolution offers tracking of SNPs in human DNA on an unprecedented scale. With the use of new genetic tools called "chips" it is possible to track and characterise precisely up to 1 million SNPs in a subject.

"We anticipate that some of these variants occur more frequently in patients with CAD compared to healthy subjects and are responsible for genetic predisposition to CAD. It is likely that some of these variants are rare so large cohorts of subjects are needed to identify sufficient numbers for analysis."

This project will conduct analysis of human DNA from more than 20 000 patients with CAD and 60 000 healthy controls.


'/>"/>

Contact: Paraskevi Christofidou
pc111@le.ac.uk
University of Leicester
Source:Eurekalert

Related biology news :

1. Does the desire to consume alcohol and tobacco come from our genetic makeup?
2. Diverse genetic abnormalities lead to NF-κB activation in multiple myeloma
3. Many parents at-risk for cancer disclose genetic test results to children
4. Genetics determine optimal drug dose of common anticoagulant
5. Claims of sex-related differences in genetic association studies often not properly validated
6. American College of Medical Genetics responds to new FDA labeling decision for warfarin
7. UNC study questions FDA genetic-screening guidelines for cancer drug
8. Genome study shines light on genetic link to height
9. Selexis Announces Advanced Approach to Maximize Power of Genetic Elements for Rapid Development of High Performance Cell Lines
10. Genes, Environment and Health Initiative invests in genetic studies, environmental monitoring
11. Rutgers Genetics receives $7.8 million for autism research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/3/2016)... 2016 --> ... "Automated Fingerprint Identification System Market by Component (Hardware and ... & Finance, Government, Healthcare, and Transportation) and Geography - ... is expected to be worth USD 8.49 Billion by ... and 2020. The transformation and technology evolution from the ...
(Date:2/2/2016)... YORK , Feb. 2, 2016 /PRNewswire/ ... facilities are primarily focused on medical screening ... measure point-of-care parameters. Wearable devices that facilitate ... user,s freedom of movement are being bolstered ... for human biomedical signal acquisition coupled with ...
(Date:2/2/2016)... YORK , Feb. 2, 2016 Technology Enhancements ... presents an analysis of the digital and computed radiography ... Malaysia , and Indonesia ... trends and market size, as well as regional market ... country and discusses market penetration and market attractiveness, both ...
Breaking Biology News(10 mins):
(Date:2/8/2016)... --> --> ... Point-Of-Care (POC) molecular diagnostics company, today announces that it has ... to be launched on the Company,s io® platform. By meeting ... is now cleared for sale within the European Union. ... the io® CT test signals a new era in ultra-rapid ...
(Date:2/5/2016)... DIEGO , Feb. 5, 2016 On ... region,s trusted information source for community, health and disaster ... Diego) will integrate to enhance care coordination and ... to the services they need and to better connect ... improve care.   San Diego ...
(Date:2/4/2016)... Feb. 4, 2016  Sangamo BioSciences, Inc. (NASDAQ: ... today that Edward Lanphier , Sangamo,s president and ... progress of Sangamo,s ZFP Therapeutic ® development programs ... 2:40 pm ET on Thursday, February 11, 2016, at ... Conference. The conference is being held in ...
(Date:2/4/2016)... and MENLO PARK, Calif. , Feb. ... ("DelMar" and the "Company"), a biopharmaceutical company focused on the ... it will present at the 18 th Annual ... 2016 at 10:00 a.m. EST in New York, ... president and CEO, will provide an update on the ongoing ...
Breaking Biology Technology: