Navigation Links
How genetic 'chips' could help to understand heart disease
Date:6/24/2010

New research at the University of Leicester will use the latest genetic techniques to examine DNA from over 20,000 patients with heart disease.

The study will help to identify new genes and molecules responsible for Coronary Artery Disease (CAD). This, in turn may help to develop new diagnostic and treatment strategies.

The project is being undertaken by postgraduate researcher Paraskevi Christofidou, of the Department of Cardiovascular Sciences. Preliminary findings from her research will be presented at the University of Leicester on 24 June.

Miss Christofidou said: "Coronary Artery Disease - a disease causing narrowing of arteries in the heart - remains a major cause of death worldwide. Shockingly, in the USA on average one person dies of this disease every 34 seconds. In the UK it causes over 100 000 deaths a year, approximately one in five deaths in men and one in six deaths in women.

"Various risk factors such as high blood pressure, smoking, obesity and increased levels of cholesterol play a significant role in the progression of CAD. There is also evidence that familial predisposition is a strong risk factor. Indeed, your risk of CAD increases by almost 50% if one of your relatives has a history of heart disease. "

Miss Christofidou said a part of this genetic susceptibility to CAD is transmitted from one generation to another as a collection of small changes in DNA sequence called single nucleotide polymorphisms (SNPs).

She added: "The recent genetic revolution offers tracking of SNPs in human DNA on an unprecedented scale. With the use of new genetic tools called "chips" it is possible to track and characterise precisely up to 1 million SNPs in a subject.

"We anticipate that some of these variants occur more frequently in patients with CAD compared to healthy subjects and are responsible for genetic predisposition to CAD. It is likely that some of these variants are rare so large cohorts o
'/>"/>

Contact: Paraskevi Christofidou
pc111@le.ac.uk
University of Leicester
Source:Eurekalert

Page: 1 2

Related biology news :

1. Does the desire to consume alcohol and tobacco come from our genetic makeup?
2. Diverse genetic abnormalities lead to NF-κB activation in multiple myeloma
3. Many parents at-risk for cancer disclose genetic test results to children
4. Genetics determine optimal drug dose of common anticoagulant
5. Claims of sex-related differences in genetic association studies often not properly validated
6. American College of Medical Genetics responds to new FDA labeling decision for warfarin
7. UNC study questions FDA genetic-screening guidelines for cancer drug
8. Genome study shines light on genetic link to height
9. Selexis Announces Advanced Approach to Maximize Power of Genetic Elements for Rapid Development of High Performance Cell Lines
10. Genes, Environment and Health Initiative invests in genetic studies, environmental monitoring
11. Rutgers Genetics receives $7.8 million for autism research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2015)... March 24, 2015   NexID Biometrics LLC, ... security-authentication needs, today announced the beginning of shipments of ... The company, based in Potsdam, ... three-day Connect:ID Expo, which began here today at the ... version 2.0 of its SDK boosts the accuracy rate ...
(Date:3/23/2015)... BOSTON, Mass , March 23, 2015 SoundView ... shipment of NXT-ID,s (NASDAQ: NXTD ) Wocket smart wallet. SoundView ... world user feedback on their experience with the Wocket in ... experience at CVS, Whole Foods and other retailers, making both ... Kris Tuttle also says, "If the company meets ...
(Date:3/23/2015)... , March 23, 2015  In the 2014 fiscal ... case conviction losses. This figure accounts for a fraction ... to The Nilson Report, exceeds $11 billion globally. The ... after a crime has occurred. Investor Mark Saint ... expert Joe Paolella partnered to administer the ...
Breaking Biology News(10 mins):NexID Begins Shipments Of Version 2.0 Fake-Finger-Detection Solution 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 3Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 4Polygraph Test Now Used to Protect Investors From Fraud 2Polygraph Test Now Used to Protect Investors From Fraud 3
... come out of research conducted on the edge of ... Olduvai Gorge in Tanzania since that produced by Louis ... a special issue of the prestigious Journal of ... of the Bernard Price Institute for Palaeontological Research, and ...
... on a unique vertebrate called the sea lamprey shows that ... development. These genes are paradoxically lost all throughout the developing ... or PGCs. The PGCs can be thought of as embryonic ... generation of lampreys. Based on computational analysis, a significant number ...
... rapidly create healthy clots and nearly double the survival ... research shows. "We knew an injection of these ... bleeding is stopped in time to increase survival following ... at Case Western Reserve University and leader of the ...
Cached Biology News:Dawn of humanity illuminated in special journal edition - 50 years after the Leakeys 2Research reveals unique solution to gene regulation 2Nanoparticles added to platelets double internal injury survival rate 2
(Date:3/27/2015)... March 27, 2015 WuXi PharmaTech (Cayman) ... R&D capability and technology platform company serving the ... today that an Investigational New Drug (IND) application ... rheumatoid arthritis has been accepted for review by ... In September 2012, MedImmune, the global ...
(Date:3/26/2015)... SQI Diagnostics Inc. ("SQI" or the "Company") (TSX-V: SQD; ... including the appointment of auditors, its annual and special ... "Meeting") was adjourned, as previously disclosed on March 25, ... Toronto time). The date of the ... The Meeting will reconvene at the offices of the ...
(Date:3/26/2015)... BOSTON , March 26, 2015 /PRNewswire/ ... ), a global clinical research organization ... signed a definitive agreement to acquire all ... India ("QSI"), a leading provider of specialized ... refers to the collection, detection, assessment, monitoring, ...
(Date:3/25/2015)... pharmaceutical market is one of the most ... its absolute size, plus a growing economy and increasing ... Business Monitor International. The Russian market is set to ... market, with growth estimates around 10-15% annually reaching an ... About Green Cross Green Cross provides ...
Breaking Biology Technology:Investigational New Drug Application for WuXi MedImmune's Monoclonal Antibody Accepted for Review by CFDA 2Investigational New Drug Application for WuXi MedImmune's Monoclonal Antibody Accepted for Review by CFDA 3SQI Diagnostics Inc. Announces Adjournment of Meeting 2PAREXEL Announces Execution of Definitive Agreement to Acquire Quantum Solutions India, Strengthening Leadership In Pharmacovigilance Services 2PAREXEL Announces Execution of Definitive Agreement to Acquire Quantum Solutions India, Strengthening Leadership In Pharmacovigilance Services 3PAREXEL Announces Execution of Definitive Agreement to Acquire Quantum Solutions India, Strengthening Leadership In Pharmacovigilance Services 4
... SAN DIEGO, March 25 ADVENTRX Pharmaceuticals, Inc. (NYSE ... for the fourth quarter and year ended December 31, ... we advanced a new business model focused on lower-risk ... our new lead programs, but given the difficult economic ...
... RICHMOND, Va., March 25 Insmed Inc. (Nasdaq: ... today announced that on Monday, March 23, 2009, NASDAQ issued ... a minimum $1 closing bid price and those rules requiring ... The suspension will remain in effect through Friday, July 17, ...
... - Oncolytics Biotech Inc. ("Oncolytics") (TSX:ONC, NASDAQ: ... enrolment in its U.K. clinical trial to evaluate ... in combination with gemcitabine (Gemzar(R)) in patients with ... The principal investigators are Dr. Johann de Bono ...
Cached Biology Technology:ADVENTRX Pharmaceuticals, Inc. Reports Fourth Quarter and Full Year 2008 Financial Results 2ADVENTRX Pharmaceuticals, Inc. Reports Fourth Quarter and Full Year 2008 Financial Results 3ADVENTRX Pharmaceuticals, Inc. Reports Fourth Quarter and Full Year 2008 Financial Results 4ADVENTRX Pharmaceuticals, Inc. Reports Fourth Quarter and Full Year 2008 Financial Results 5ADVENTRX Pharmaceuticals, Inc. Reports Fourth Quarter and Full Year 2008 Financial Results 6ADVENTRX Pharmaceuticals, Inc. Reports Fourth Quarter and Full Year 2008 Financial Results 7Insmed Announces That NASDAQ Further Extends Temporary Suspension of Minimum Bid Closing Price Rule 2Oncolytics Biotech(R) Inc. Completes Enrolment in Combination REOLYSIN(R)/Gemcitabine Trial 2Oncolytics Biotech(R) Inc. Completes Enrolment in Combination REOLYSIN(R)/Gemcitabine Trial 3
Request Info...
... 2 , Maintenance 112 days/each ... , Immunizations/Boost injections x5 /each ... /each , Production bleed (25 ml ... Bleed ~ 100 ml blood (~50 ml serum) x1 ...
FluoSpheres® biotin-labeled microspheres, 1.0 µm, yellow-green fluorescent (505/515) *1% solids*...
chk 1 kinase...
Biology Products: