Navigation Links
How fatty diets cause diabetes
Date:8/14/2011

SANTA BARBARA, Calif., August 14, 2011 Newly diagnosed type 2 diabetics tend to have one thing in common: obesity. Exactly how diet and obesity trigger diabetes has long been the subject of intense scientific research. A new study led by Jamey D. Marth, Ph.D., director of the Center for Nanomedicine, a collaboration between the University of California, Santa Barbara and Sanford-Burnham Medical Research Institute (Sanford-Burnham), has revealed a pathway that links high-fat diets to a sequence of molecular events responsible for the onset and severity of diabetes. These findings were published online August 14 in Nature Medicine.

In studies spanning mice and humans, Dr. Marth's team discovered a pathway to disease that is activated in pancreatic beta cells, and then leads to metabolic defects in other organs and tissues, including the liver, muscle and adipose (fat). Together, this adds up to diabetes.

"We were initially surprised to learn how much the pancreatic beta cell contributes to the onset and severity of diabetes," said Dr. Marth."The observation that beta cell malfunction significantly contributes to multiple disease signs, including insulin resistance, was unexpected. We noted, however, that studies from other laboratories published over the past few decades had alluded to this possibility."

In healthy people, pancreatic beta cells monitor the bloodstream for glucose using glucose transporters anchored in their cellular membranes. When blood glucose is high, such as after a meal, beta cells take in this additional glucose and respond by secreting insulin in a timed and measured response. In turn, insulin stimulates other cells in the body to take up glucose, a nutrient they need to produce energy.

In this newly discovered pathway, high levels of fat were found to interfere with two key transcription factorsproteins that switch genes on and off. These transcription factors, FOXA2 and HNF1A, are normally
'/>"/>

Contact: Heather Buschman, Ph.D.
hbuschman@sanfordburnham.org
858-795-5343
Sanford-Burnham Medical Research Institute
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Gene variant increases fatty liver risk and fibrosis progression
2. Scientists develop a fatty kryptonite to defeat multidrug-resistant Super bugs
3. Fish livers contain beneficial fatty acids
4. New data show non-alcoholic fatty liver disease will reach epidemic status in the US
5. New sleep cycle discovery explains why fatty diets during pregnancy make kids obese
6. Consuming polyunsaturated fatty acids may lower the incidence of gum disease
7. U of I study: Lack of omega-3 fatty acid linked to male infertility
8. U of I study: Lack of omega-6 fatty acid linked to severe dermatitis
9. How much omega-3 fatty acid do we need to prevent cardiovascular disease?
10. Omega-3 fatty acids appear to impact AMD progression
11. Fatty foods -- not empty stomach -- fire up hunger hormone
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
How fatty diets cause diabetes
(Date:3/30/2015)... , Mar. 26, 2015 Research and Markets ... of the "Global Gesture Recognition Market in Automotive ... The analysts forecast the Global Gesture Recognition market in ... over the period 2013-2018. Gesture recognition is ... to different gestures of an individual. Gesture recognition technology ...
(Date:3/24/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/hdgz7h/global_iris ... Iris Recognition Market 2015-2019" report to their offering. ... market to grow at a CAGR of 23.5 percent ... the present scenario and the growth prospects of the ... calculate the market size, the report considers the revenue ...
(Date:3/24/2015)... , March 24, 2015   NexID Biometrics ... critical security-authentication needs, today announced the beginning of shipments ... solution. The company, based in ... the three-day Connect:ID Expo, which began here today at ... said version 2.0 of its SDK boosts the accuracy ...
Breaking Biology News(10 mins):Global Gesture Recognition Market in Automotive Sector Report 2015 - Growing Number of Partnerships 2Global Iris Recognition Market 2015-2019 with 3M Cogent, Bioenable Technologies, Cross Match Technology, Iris ID Systems & Safran Dominating 2NexID Begins Shipments Of Version 2.0 Fake-Finger-Detection Solution 2
... within the southern Indian Ocean is helping protect the ... between Africa, India, Australia and Antarctica, the windswept French ... remotest places on Earth. Even so, fishing vessels are ... species found in its surrounding waters ?the Patagonian toothfish, ...
... Marijuana--or more specifically its active ingredient, tetrahydrocannabinol--has ... while scientists have traced this property to ... had little understanding of the neural circuitry ... has important practical implications because blocking the ...
... tsunami devastated South Asian communities, global fisheries experts ... much needed to revive severely exhausted fisheries and ... , According to new analyses by the Malaysia-based ... Equal Rebuilding Livelihoods and ? Rehabilitating Livelihoods in ...
Cached Biology News:Envisat radar surveillance protects endangered prehistoric fish 2Envisat radar surveillance protects endangered prehistoric fish 3Machinery of the 'marijuana munchies' 2Tsunami + 1 year: Reviving exhausted fisheries should trump replacing boats, gear, experts say 2Tsunami + 1 year: Reviving exhausted fisheries should trump replacing boats, gear, experts say 3Tsunami + 1 year: Reviving exhausted fisheries should trump replacing boats, gear, experts say 4
(Date:3/30/2015)... March 30, 2015 PMG Research, ... to announce the formation of VaxCorps, a network ... specializing in the conduct of vaccine trials in ... clinical sites have successfully conducted over 500 phase ... seasonal and pandemic influenza as well as a ...
(Date:3/30/2015)... March 30, 2015 US-Australian drug discovery company, ... subsidiary, CanTx, Inc., and Yale University, on March 27 ... data was presented as an oral presentation by Professor ... School to the 62 nd Annual Scientific Meeting ... San Francisco, CA. In both ...
(Date:3/30/2015)... UK, and BELLINGHAM, Washington, USA (PRWEB) March 29, 2015 ... projects in Europe and the United States and plenary ... highlights planned for SPIE Optics + Optoelectronics ... feature over 700 technical presentations in 17 conferences alongside ... society for optics and photonics , the event will ...
(Date:3/29/2015)... 29, 2015  Caris Life Sciences® today announced ... Molecular Intelligence®, the company,s panomic, comprehensive tumor profiling ... several rare and difficult to treat gynecological cancers ... potential to improve patient outcomes. These studies were ... Society of Gynecologic Oncology (SGO) 2015 Annual Meeting ...
Breaking Biology Technology:PMG Research announces formation of VaxCorps with two industry-leading vaccine site networks 2Yale University and Novogen Release Data on Cantrixil Mode of Action 2Yale University and Novogen Release Data on Cantrixil Mode of Action 3Yale University and Novogen Release Data on Cantrixil Mode of Action 4Laser Energy Advances Among Reports Set for SPIE Optics + Optoelectronics 2Laser Energy Advances Among Reports Set for SPIE Optics + Optoelectronics 3Caris Molecular Intelligence Facilitates Comparison of Biomarker Profiles to Inform Targeted Treatment Strategies in Distinct Gynecological Cancers 2Caris Molecular Intelligence Facilitates Comparison of Biomarker Profiles to Inform Targeted Treatment Strategies in Distinct Gynecological Cancers 3Caris Molecular Intelligence Facilitates Comparison of Biomarker Profiles to Inform Targeted Treatment Strategies in Distinct Gynecological Cancers 4
... - Gov. Jim Doyle selected two local ... Authority - both of whom expressed eagerness about their ... travel. , ,Mark Hanna, a city alderman, and Judy ... several already-named nominees for the commission, which will be ...
... much like to be proven wrong, but he thinks ... industry in metropolitan Milwaukee - a component of the ... southeastern Wisconsin. , ,Mascari, director of development for ... are likely to continue their dominance in the park, ...
... musical combinations to new web applications, mashups are creating ... are created by combining the soundtracks of one song ... sound (see Mashuptown ). , ,On the ... data sources like maps, weather, classified listings, or other ...
Cached Biology Technology:Wisconsin spaceport committee moves closer to formation 2Does Milwaukee need a life-science spark? 2Does Milwaukee need a life-science spark? 3Does Milwaukee need a life-science spark? 4Would you like your music (and data) mashed? 2Would you like your music (and data) mashed? 3Would you like your music (and data) mashed? 4Would you like your music (and data) mashed? 5
Recombinant Mouse TGF-beta RII/(human) Fc Chimera, CF...
Phospho-TAO2 (S181) Affinity Purified Polyclonal Ab Protein Family: Other Intracellular Kinases...
Human Norrin Biotinylated Affinity Purified PAb Protein Family: Other Growth Factors, Other Wnt-related Molecules...
PEG 8000, Molecular Biology Grade...
Biology Products: