Navigation Links
How fat are your lab mice?
Date:4/4/2012

Researchers are increasingly aware that fat in some parts of the body is more harmful than fat in other places. To help determine how obesity works, scientists turn to animal models and now, they are able to visualize how much fat their lab rats are carrying and where they are storing it. The method will be published in the April issue of the Journal of Visualized Experiments (JoVE).

"One of the key benefits of this technique versus existing methods, like ex vivo analysis, is that this technique allows for non-invasive and longitudinal assessment of fat in small animal disease models," said paper-author Dr. Todd Sasser.

Traditionally, researchers have had to use either invasive techniques, which provide more insight into where fat is being stored specifically but result in the death of the mouse, or less specific, non-invasive imaging techniques. Here, they use dedicated small animal X-ray computed tomography (CT) and customized analytics to see how the fat is distributed inside the animal.

The process is highly visual, resulting in three-dimensional images of the fat within the mouse, which is why the researchers chose to publish their method in JoVE, the only peer reviewed, PubMed-indexed science journal to publish all of its content in both text and video format.

"Generally, individuals new to this method will struggle, because the segmentation and visualization protocol includes several steps that must be completed in succession," said co-author Sarah Chapman, from the University of Notre Dame.

"As obesity and obesity-related illnesses continue to grow into worldwide problems, it is important to understand their fundamental causes and potential interventions," said JoVE Science Editor, Dr. Charlotte Frank Sage. "This technique details imaging and analysis technology that enables researchers to longitudinally and quantitatively study adipose content at a high level of detail."


'/>"/>

Contact: Katherine Scott
katherine.scott@jove.com
617-765-4367 x301
The Journal of Visualized Experiments
Source:Eurekalert  

Page: 1

Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
How fat are your lab mice?
(Date:4/19/2016)... , UAE, April 20, 2016 ... implemented as a compact web-based "all-in-one" system solution for ... biometric fingerprint reader or the door interface with integration ... modern access control systems. The minimal dimensions of the ... readers into the building installations offer considerable freedom of ...
(Date:4/13/2016)... -- IMPOWER physicians supporting Medicaid patients in Central ... in telehealth thanks to a new partnership with higi. ... patients can routinely track key health measurements, such as ... when they opt in, share them with IMPOWER clinicians ... retail location at no cost. By leveraging this data, ...
(Date:3/23/2016)... Massachusetts , March 23, 2016 /PRNewswire/ ... im Interesse erhöhter Sicherheit Gesichts- und Stimmerkennung ... Xura, Inc. (NASDAQ: MESG ), ... bekannt, dass das Unternehmen mit SpeechPro zusammenarbeitet, ... aus der Finanzdienstleistungsbranche, wird die Möglichkeit angeboten, ...
Breaking Biology News(10 mins):
(Date:5/25/2016)... ... May 25, 2016 , ... WEDI, the nation’s leading ... today announced that Charles W. Stellar has been named by the WEDI Board of ... January 2016. As an executive leader with more than 35 years of experience in ...
(Date:5/24/2016)... Mass. (PRWEB) , ... May 24, 2016 , ... ... heart attacks, diabetes, and traumatic injuries, will be accelerated by research at Worcester ... cells into engines of wound healing and tissue regeneration. , The novel method, ...
(Date:5/24/2016)... (PRWEB) , ... May 24, 2016 , ... ... a newly re-branded identity. The new Media Cybernetics corporate branding reflects a results-driven ... of imaging and image analysis. The re-branding components include a crisp, refreshed logo ...
(Date:5/23/2016)... , May 23, 2016 Zimmer Biomet Holdings, Inc. ... today announced that its Board of Directors has approved the ... second quarter of 2016. The cash dividend ... July 29, 2016 to stockholders of record as of the ... dividends are subject to approval of the Board of Directors ...
Breaking Biology Technology: