Navigation Links
How fat are your lab mice?
Date:4/4/2012

Researchers are increasingly aware that fat in some parts of the body is more harmful than fat in other places. To help determine how obesity works, scientists turn to animal models and now, they are able to visualize how much fat their lab rats are carrying and where they are storing it. The method will be published in the April issue of the Journal of Visualized Experiments (JoVE).

"One of the key benefits of this technique versus existing methods, like ex vivo analysis, is that this technique allows for non-invasive and longitudinal assessment of fat in small animal disease models," said paper-author Dr. Todd Sasser.

Traditionally, researchers have had to use either invasive techniques, which provide more insight into where fat is being stored specifically but result in the death of the mouse, or less specific, non-invasive imaging techniques. Here, they use dedicated small animal X-ray computed tomography (CT) and customized analytics to see how the fat is distributed inside the animal.

The process is highly visual, resulting in three-dimensional images of the fat within the mouse, which is why the researchers chose to publish their method in JoVE, the only peer reviewed, PubMed-indexed science journal to publish all of its content in both text and video format.

"Generally, individuals new to this method will struggle, because the segmentation and visualization protocol includes several steps that must be completed in succession," said co-author Sarah Chapman, from the University of Notre Dame.

"As obesity and obesity-related illnesses continue to grow into worldwide problems, it is important to understand their fundamental causes and potential interventions," said JoVE Science Editor, Dr. Charlotte Frank Sage. "This technique details imaging and analysis technology that enables researchers to longitudinally and quantitatively study adipose content at a high level of detail."


'/>"/>

Contact: Katherine Scott
katherine.scott@jove.com
617-765-4367 x301
The Journal of Visualized Experiments
Source:Eurekalert  

Page: 1

Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
How fat are your lab mice?
(Date:6/30/2017)... Today, American Trucking Associations announced Seeing ... and eye tracking software, became the newest member ... "Artificial intelligence and advanced sensing algorithms ... driver,s attentiveness levels while on the road.  Drivers ... fatigue and prevent potential accidents, which could lead ...
(Date:5/16/2017)... -- Veratad Technologies, LLC ( www.veratad.com ), an innovative and ... solutions, announced today they will participate as a sponsor ... May 17, 2017, in Washington D.C.,s ... Identity impacts the lives of billions of ... digital world, defining identity is critical to nearly every ...
(Date:4/19/2017)... , April 19, 2017 ... its vendor landscape is marked by the presence of ... is however held by five major players - 3M ... these companies accounted for nearly 61% of the global ... leading companies in the global military biometrics market boast ...
Breaking Biology News(10 mins):
(Date:8/15/2017)... ... 2017 , ... The Conference Forum and The Trout Group ... series of upcoming panels and events. The partnership culminates with the 4th Annual ... New York City. , “With our experience in producing the Immuno-Oncology 360° NYC event ...
(Date:8/14/2017)... ... August 14, 2017 , ... Opal Kelly, ... USB or PCI Express, announced the release of SYZYGY™, a new open standard ... the need for a compact, low cost, low pin-count, high-performance connectivity solution between ...
(Date:8/11/2017)... ... August 11, 2017 , ... Algenist continues to disrupt the skincare industry ... never before. , Collagen is the key structural element skin needs to maintain ... which include: , First to market with proprietary collagen ...
(Date:8/10/2017)... ... August 09, 2017 , ... The era ... clinic is here. The team at Capricor Therapeutics, Inc. utilized a cardiosphere-derived stem-like ... studies. , Dr. Travis Antes, head of analytical development at Capricor Therapeutics ...
Breaking Biology Technology: