Navigation Links
How eating fruit and vegetables can improve cancer patients' response to chemotherapy
Date:10/22/2008

RIVERSIDE, Calif. The leading cause of death in all cancer patients continues to be the resistance of tumor cells to chemotherapy, a form of treatment in which chemicals are used to kill cells.

Now a study by UC Riverside biochemists that focuses on cancer cells reports that ingesting apigenin a naturally occurring dietary agent found in vegetables and fruit improves cancer cells' response to chemotherapy.

Xuan Liu, a professor of biochemistry, and Xin Cai, a postdoctoral researcher working in her lab, found that apigenin localizes tumor suppressor p53, a protein, in the cell nucleus a necessary step for killing the cell that results in some tumor cells responding to chemotherapy.

The study, published this week in the online early edition of the Proceedings of the National Academy of Sciences, provides a novel approach to conquer tumor resistance to chemotherapy, and suggests an avenue for developing safe chemotherapy via naturally occurring agents.

Normally, cells have low levels of p53 diffused in their cytoplasm and nucleus. When DNA in the nucleus is damaged, p53 moves to the nucleus where it activates genes that stop cell growth and cause cell death. In this way, p53 ensures that cells with damaged DNA are killed.

In many cancers, p53 is rendered inactive by a process called cytoplasmic sequestration. Apigenin is able to activate p53 and transport it into the nucleus, resulting in a stop to cell growth and cell death.

"In therapy you want to kill cancer cells," explained Cai, the first author of the research paper. "But to stop cell growth and to kill the cell, p53 first needs to be moved to the cell's nucleus to function. Apigenin is very effective in localizing p53 this way."

Apigenin is mainly found in fruit (including apples, cherries, grapes), vegetables (including parsley, artichoke, basil, celery), nuts and plant-derived beverages (including tea and wine). It has been shown by researchers to have growth inhibitory properties in several cancer lines, including breast, colon, skin, thyroid and leukemia cells. It has also been shown to inhibit pancreatic cancer cell proliferation.

"Our study advocates the inclusion of vegetables and fruit in our daily diet to help prevent cancer," said Liu, the research paper's coauthor.


'/>"/>

Contact: Iqbal Pittalwala
iqbal@ucr.edu
951-827-6050
University of California - Riverside
Source:Eurekalert

Related biology news :

1. Gamma globulin effective in treating eye infections caused by adenoviruses
2. Eating competence may lower risk of heart disease
3. Alternative food networks connect ethical producers and consumers and can lead to healthier eating
4. Gregory Hannon wins 2007 Paul Marks Prize for contributions to understanding and treating cancer
5. Massive microRNA scan uncovers leads to treating muscle degeneration
6. Sirtris unveils promising, novel SIRT1 activators for treating diseases of aging
7. Having the climate cake and eating it, too
8. Hellish hot springs yield greenhouse gas-eating bug
9. Tiny pest-eating insect fights fruit flies
10. Building disease-beating wheat
11. International scientists tackle obstacles to treating brain disorders
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2017)... -- Janice Kephart , former 9/11 Commission ... LLP (IdSP) , today issues the following statement: ... 6, 2017 Executive Order: Protecting the Nation ... instilled with greater confidence, enabling the reactivation of ... are suspended by until at least July 2017). ...
(Date:4/17/2017)... Florida , April 17, 2017 NXT-ID, ... technology company, announces the filing of its 2016 Annual Report on ... and Exchange Commission. ... on Form 10-K is available in the Investor Relations section of ... as on the SEC,s website at http://www.sec.gov . ...
(Date:4/11/2017)... GARDENS, Fla. , April 11, 2017 /PRNewswire/ ... management and secure authentication solutions, today announced that ... by Intelligence Advanced Research Projects Activity (IARPA) to ... IARPA,s Thor program. "Innovation has been ... and IARPA,s Thor program will allow us to ...
Breaking Biology News(10 mins):
(Date:5/18/2017)... ... 2017 , ... When James Sherley, was notified earlier this year that his company Asymmetrex ... 2017 by The Silicon Review , he was not surprised as others might be. ... but this recognition by Silicon Valley was particularly meaningful. Our selection by ...
(Date:5/16/2017)... ... 16, 2017 , ... Cynvenio Biosystems, Inc. a ... Cancer blood test. Leveraging a highly-sensitive next-generation sequencing panel of 11 genes known ... and accurately identify tumor-related genetic mutations that can be treated with targeted therapies. ...
(Date:5/15/2017)... (PRWEB) , ... May 15, 2017 , ... Tunnell ... in a presentation of “The Key Role of Specifications in Process Validation,” at the ... Philadelphia . The event will bring together leaders from the pharmaceutical and biotech industries ...
(Date:5/15/2017)... , May 15, 2017  IBM (NYSE: IBM ... can stretch double-stranded DNA molecules with the potential ... This technology complements the IBM Research,s ... such as exosomes and which may also contain ... uses an array of diamond shaped micropillars 1 ...
Breaking Biology Technology: