Navigation Links
How does ursolic acid induce neural regeneration after sciatic nerve injury?
Date:10/25/2013

Ursolic acid (chemical name 3-hydroxy-12- ursen-28-oic acid) is a triterpenoid extracted from natural plant-based drugs, and has anti-oxidative, anti-inflammatory, anti-apoptotic, and anti-scarring effects, and it regulates the immune system and promotes the repair of injured neurons.However, no reports have explored its role in peripheral nerve injury. A recent study by Prof. Jiajun Chen and team from China-Japan Union Hospital of Jilin University, China established mouse models of sciatic nerve injury through unilateral sciatic nerve complete transection and microscopic anastomosis. The successfully generated model mice were treated with 10, 5, or 2.5 mg/kg ursolic acid via intraperitoneal injection. This study, published in the Neural Regeneration Research (Vol. 8, No. 27, 2013), is the first to demonstrate a role of ursolic acid in repair and regeneration following peripheral nerve injury. Ursolic acid promoted the regeneration of injured nerve myelin sheaths and reconstructed muscular functions. All experimental findings provide favorable evidence for the application of ursolic acid following peripheral nerve injury.


'/>"/>

Contact: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
Source:Eurekalert

Page: 1

Related biology news :

1. Induced pluripotent stem cells reveal differences between humans and great apes
2. Fetal stem cell transplantation favorably impacts radiation-induced cognitive dysfunction
3. Hitting the gym may help men avoid diet-induced erectile dysfunction
4. Why does a high-fat diet induce preeclampsia-like symptoms in pregnant rats?
5. Pitt team finds mechanism that causes noise-induced tinnitus and drug that can prevent it
6. Serotonin mediates exercise-induced generation of new neurons
7. Discovery may help prevent chemotherapy-induced anemia
8. NYSCF scientists develop new protocol to ready induced pluripotent stem cell clinical application
9. Study: Probiotics reduce stress-induced intestinal flare-ups
10. Study pinpoints, prevents stress-induced drug relapse in rats
11. Neuronal activity induces tau release from healthy neurons
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/16/2014)... 2014 As open enrollment season approaches, U.S. employees ... their 2015 benefits. According to Aon Hewitt , ... Aon plc (NYSE: AON ), ... role in managing their health care decisions. This increased ... to understand how they can make the most of ...
(Date:9/15/2014)... (September 15, 2014) The so-called central dogma ... proteinhas long provided a simplified explanation for how ... organisms. , In reality, of course, the ... first articulated nearly 60 years ago by Nobel ... structure. For one, there are multiple types of ...
(Date:9/15/2014)... epilepsy drug to a morphine regimen can result in ... combination can reduce the dosage of the opioid needed ... researchers at Indiana University. , The result could bring ... difficult-to-treat condition often felt in the arms and legs ... a huge unmet need for better treatments for neuropathic ...
Breaking Biology News(10 mins):Aon Hewitt Provides Tips to Help Workers Prepare for the Upcoming Open Enrollment Season 2Aon Hewitt Provides Tips to Help Workers Prepare for the Upcoming Open Enrollment Season 3Aon Hewitt Provides Tips to Help Workers Prepare for the Upcoming Open Enrollment Season 4Aon Hewitt Provides Tips to Help Workers Prepare for the Upcoming Open Enrollment Season 5Aon Hewitt Provides Tips to Help Workers Prepare for the Upcoming Open Enrollment Season 6Aon Hewitt Provides Tips to Help Workers Prepare for the Upcoming Open Enrollment Season 7Scientists discover RNA modifications in some unexpected places 2IU study: Combining epilepsy drug, morphine can result in less pain, lower opioid doses 2
... A new research report published online in The FASEB Journal ... sugar and high fat diets have babies who are likely ... which used rats, this happens because the high fat and ... reward pathway, altering food preferences. Not only does this offer ...
... Minnesota researchers are a key step closer to making renewable ... by a $2.2 million United States Department of Energy grant. ... January, made the critical step by figuring out how to ... bacteria into ketones, which can be cracked to make hydrocarbon ...
... has been used to treat heroin addicts for nearly ... possible harmful effects from prolonged use. New research from ... affects the brain and impairs the attention of experimental ... and morphine are known to weaken intellectual functions such ...
Cached Biology News:'Junk food' moms have 'junk food' babies 2U of M researchers close in on technology for making renewable petroleum 2Long-term methadone treatment can affect the brain 2
(Date:9/16/2014)... In preparation for VARTECH 2014, 2FA, Inc., ... focused on authentication and SSO announced today that their ... generate a OTP through the presentation of an RFID ... RFID authentication, 2FA,s solutions have leveraged the existence of ... RFID authentication is broadly deployed in healthcare and other ...
(Date:9/15/2014)... 15, 2014   Global Science & Technology, ... products and services for satellite and weather systems, ... Integrated Services (OASIS) from the General Services Administration ... to provide the government best-value solutions for complex ... category in Pool 4. The OASIS SB award ...
(Date:9/15/2014)... downhill fast when a patient has sepsis, a life-threatening ... patient,s blood -- often too fast for antibiotics to ... and developed by a team at Harvard,s Wyss Institute ... doctors treat sepsis. , "Even with the best ... units at least 30 percent of the time," said ...
(Date:9/15/2014)... , Sept. 15, 2014  iVinci Health LLC, the ... Patient Revenue Management system, branded as VisitPay®, has successfully ... announced the launch of a new extension to VisitPay® ... an easy and convenient way for patients to manage ... owed by them and their families. The ...
Breaking Biology Technology:2FA, Inc. Announces RFID-based One-Time Password (OTP) Authentication 2Global Science & Technology, Inc. Awarded GSA OASIS Small Business Contract 2Global Science & Technology, Inc. Awarded GSA OASIS Small Business Contract 3Blood-cleansing biospleen device developed for sepsis therapy 2Blood-cleansing biospleen device developed for sepsis therapy 3Blood-cleansing biospleen device developed for sepsis therapy 4iVinci Health Raises $5M to Fuel National Expansion, Announces Launch of Personal Finance Portal for Healthcare 2iVinci Health Raises $5M to Fuel National Expansion, Announces Launch of Personal Finance Portal for Healthcare 3
... TAMPA, Fla., May 1 MiMedx Group, Inc. ... Wallace, former,President of UPS International, has been appointed ... Commenting on the appointment, Thomas D,Alonzo, Chief ... of Ron,s stature,independence and knowledge to our Board. ...
... May 1 Sidec announces the first,Protein ... PEGS. This Award,is set up to enable ... not yet collaborated with Sidec on a ... groundbreaking technology successfully used in,cancer drug research., ...
... Doctors Changing the Face of ... ... ENTERPRISE (BE),unveils its 2008 report on the best and brightest in medicine. ... lives through the revolutionary treatment of,diseases, from cancer and diabetes to heart ...
Cached Biology Technology:MiMedx Group, Inc. Adds Ronald G. Wallace to Board of Directors 2Sidec Announces the First Protein Tomography(TM) Award at Sidec's Executive Forum at PEGS 2Black Enterprise Unveils America's Leading Doctors 2Black Enterprise Unveils America's Leading Doctors 3
... Hollandes is a fixative useful for routine ... It is stable and will decalcify small ... Hollande's can be stained successfully with most ... solution stabilizes red blood cell membranes and ...
... The gold standard for automated ... of bioanalytical applications • Based on ... • Automated accessories designed for bioresearch ... light • Versatility, reliability and ease-of-use ...
... In Vitro Osteogenesis Assay Kit contains all ... a mature osteoblastic lineage, as determined by ... provides all the necessary reagents and a ... plate reader. This product is useful for ...
... Acuity is the complete enterprise microarray informatics platform ... analysis. Buy Acuity once and use it forever ... Tools for Quality Acuity has all the ... from your data, from quality control statistics and ...
Biology Products: