Navigation Links
How does ursolic acid induce neural regeneration after sciatic nerve injury?
Date:10/25/2013

Ursolic acid (chemical name 3-hydroxy-12- ursen-28-oic acid) is a triterpenoid extracted from natural plant-based drugs, and has anti-oxidative, anti-inflammatory, anti-apoptotic, and anti-scarring effects, and it regulates the immune system and promotes the repair of injured neurons.However, no reports have explored its role in peripheral nerve injury. A recent study by Prof. Jiajun Chen and team from China-Japan Union Hospital of Jilin University, China established mouse models of sciatic nerve injury through unilateral sciatic nerve complete transection and microscopic anastomosis. The successfully generated model mice were treated with 10, 5, or 2.5 mg/kg ursolic acid via intraperitoneal injection. This study, published in the Neural Regeneration Research (Vol. 8, No. 27, 2013), is the first to demonstrate a role of ursolic acid in repair and regeneration following peripheral nerve injury. Ursolic acid promoted the regeneration of injured nerve myelin sheaths and reconstructed muscular functions. All experimental findings provide favorable evidence for the application of ursolic acid following peripheral nerve injury.


'/>"/>

Contact: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
Source:Eurekalert

Page: 1

Related biology news :

1. Induced pluripotent stem cells reveal differences between humans and great apes
2. Fetal stem cell transplantation favorably impacts radiation-induced cognitive dysfunction
3. Hitting the gym may help men avoid diet-induced erectile dysfunction
4. Why does a high-fat diet induce preeclampsia-like symptoms in pregnant rats?
5. Pitt team finds mechanism that causes noise-induced tinnitus and drug that can prevent it
6. Serotonin mediates exercise-induced generation of new neurons
7. Discovery may help prevent chemotherapy-induced anemia
8. NYSCF scientists develop new protocol to ready induced pluripotent stem cell clinical application
9. Study: Probiotics reduce stress-induced intestinal flare-ups
10. Study pinpoints, prevents stress-induced drug relapse in rats
11. Neuronal activity induces tau release from healthy neurons
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/22/2016)... OTTAWA, Ontario , PROVO ... 2016 Newborn Screening Ontario (NSO), which operates ... for molecular testing, and Tute Genomics and ... process management technology respectively, today announced the launch of ... new next-generation sequencing (NGS) testing panel. ...
(Date:3/17/2016)... -- ABI Research, the leader in transformative technology ... will reach more than $30 billion by 2021, ... electronics, particularly smartphones, continue to boost the biometrics ... two billion shipments by 2021 at a 40% ... Analyst at ABI Research. "Surveillance is also gearing ...
(Date:3/14/2016)... March 14, 2016 NXTD ) ("NXT-ID" ... commerce market, announces the airing of a new series of ... week of March 21 st .  The commercials will air ... popular Squawk on the Street show. --> NXTD ... growing mobile commerce market, announces the airing of a new ...
Breaking Biology News(10 mins):
(Date:5/25/2016)... ... May 25, 2016 , ... ... became double board-certified in surgery and surgery of the hand by the National ... no stranger to going above and beyond in his pursuit of providing the ...
(Date:5/25/2016)... ... May 25, 2016 , ... Biohaven Pharmaceutical Holding Company Ltd. ... the company’s orphan drug designation request covering BHV-4157 for the treatment of Spinocerebellar ... FDA. , Spinocerebellar ataxia is a rare, debilitating neurodegenerative disorder that is ...
(Date:5/23/2016)... ... ... blood donations in South Texas and across the nation is growing. , But according to ... are on the decline. In fact, donations across the country are at their lowest point ... the last four years alone. , There is no substitute for blood. , “We want ...
(Date:5/23/2016)... North Carolina (PRWEB) , ... May 23, 2016 ... ... automation and building management solutions and services based in Aurora, Ohio, has broken ... of established business in the Research Triangle Park area, this new location solidifies ...
Breaking Biology Technology: