Navigation Links
How does the opioid system control pain, reward and addictive behavior?
Date:10/14/2007

The opioid system controls pain, reward and addictive behaviors. Opioids exert their pharmacological actions through three opioid receptors, mu, delta and kappa whose genes have been cloned (Oprm, Oprd1 and Oprk1, respectively). Opioid receptors in the brain are activated by a family of endogenous peptides like enkephalins, dynorphins and endorphin, which are released by neurons. Opioid receptors can also be activated exogenously by alkaloid opiates, the prototype of which is morphine, which remains the most valuable painkiller in contemporary medicine.

By acting at opioid receptors, opiates such as morphine or heroin (a close chemically synthesized derivative) are extremely potent pain-killers, but are also highly addictive drugs.

To understand how molecules act in the brain and control behavior one can manipulate genes encoding these molecules in complex organisms, such as the mouse, and explore the consequences of these targeted genetic manipulations on animal responses in vivo.

Today, genetically modified mouse models represent a state-of-the art approach towards understanding brain function.

The direct comparison of mice lacking each of the three opioid-receptor genes reveals that mu- and delta-opioid receptors act oppositely in regulating emotional reactivity. This highlights a novel aspect of mu- and delta-receptor interactions, which contrasts with the former commonly accepted idea that activation of mu- and delta-receptors produces similar biological effects (Traynor & Elliot, 1993).

mu-opioid-receptor

The finding that morphines analgesic and addictive properties are abolished in mice lacking the mu-opioid receptor has unambiguously demonstrated that mu-receptors mediate both the therapeutic and the adverse activities of this compound (Matthes 1996). Importantly, a series of studies has shown that the reinforcing properties of alcohol, cannabinoids, and nicotine each of which acts at a different
'/>"/>

Contact: Professor Brigitte L. Kieffer
briki@igbmc.u-strasbg.fr
European College of Neuropsychopharmacology
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Key Trigger Of Opioid Withdrawal Symptoms Found
2. Genes In The Interferon System Important In Systemic Lupus Erythematosus
3. Fox Chase Cancer Center scientists identify immune-system mutation
4. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
5. Transport System Smuggles Medicines Into Brain
6. Open microfluidic and nanofluidic systems
7. Studies reveal methods viruses use to sidestep immune system
8. Alcohols effects on gene expression in the central nervous system
9. Jumping gene helps explain immune systems abilities
10. PANTHER Protein Classification System Database 5.0
11. White blood cell waste disposal system plays critical regulatory role
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... a novel method to help kidney stone sufferers ... treatment possible., Kidney stones represent a major medical ... left untreated, apart from being particularly painful, they ... In many patients treated successfully, stone recurrence is ... approach to diagnosis and treatment needs to be ...
(Date:4/17/2014)... the Cell Press journal Current Biology on ... novel sex lives. The Brazilian insects, which represent four ... , are the first example of an animal with ... identified in several different animals, Neotrogla is ... also reversed," says Kazunori Yoshizawa from Hokkaido University in ...
(Date:4/17/2014)... Branch at Galveston are the first to recommend ... cancer should begin colorectal cancer screening earlier than ... a high incidence of secondary colorectal cancers among ... recommendations that the younger women in this group ... their initial cervical cancer diagnosis instead of waiting ...
Breaking Biology News(10 mins):In sex-reversed cave insects, females have the penises 2Radiation therapy for cervical cancer increases risk for colorectal cancer 2
... University of Geneva have discovered a genetic mechanism that defines ... only a secondary role. The research published in Cell ... found in a DNA sequence that was thought, incorrectly, to ... when combined with one another, modulate the activity of the ...
... Urban legend warns shoveling snow causes heart attacks, and the ... with a family history of premature cardiovascular disease. However, until ... Two of the most important cardiology associations in the ... risk physical activity, but all the citation references indicate that ...
... end rot on tomatoes and cucumbers, bitter-pit in apples ... only compromises the flavor but also causes significant harvest ... be traced back to insufficient calcium uptake or faulty ... occur even if the soil provides sufficient calcium. A ...
Cached Biology News:Finger (mal)formation reveals surprise function of desert DNA 2
(Date:1/15/2014)... (PRWEB) January 15, 2014 DTS Language ... its Online Web Portal for Life Science organizations who need ... specify the subject matter of their documents in advance with ... help reduce time-to-delivery of translations, often a critical factor in ...
(Date:1/15/2014)... 15, 2014 TaiGen Biotechnology Company, Limited ("TaiGen") today ... R-Pharm, a leading Russian pharmaceutical company, to develop and ... Russian Federation , Turkey ... is a novel antibiotic for the treatment of bacterial ...
(Date:1/14/2014)... , Jan. 14, 2014  3D Communications, a leading provider of strategic ... business, and media events in the United States ... associate Virginia Cox , JD, is returning to the firm,s ... Cox re-joins 3D after more than two years of service ...
(Date:1/14/2014)... BETHESDA, Md. , Jan. 14, 2014  Organovo announced ... from the National Institutes of Health (NIH) to help ... effective treatments to patients on a faster timeline. Organovo ... Sciences (NCATS) and the National Eye Institute (NEI) to ...
Breaking Biology Technology:DTS Improves Efficiency for Life Science Document Translations 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 4Former FDA Associate Commissioner Returns To 3D Communications 2Organovo Announces Collaboration with National Institutes of Health 2Organovo Announces Collaboration with National Institutes of Health 3
... of,the 2007 Nobel Prize in Physiology or Medicine ... Americans for Medical,Progress congratulates Mario R. Capecchi, Martin ... by the Karolinska Institute for their,animal-based research that ... treatments and cures for countless serious ailments., ...
... Company to Present Unique Business Model, SAN ... health,and wellness company and recent consecutive year award ... genetic research,announces today that it has been selected ... investor meeting, October 17, 2007 in San,Francisco, CA. ...
... 9 Boston Scientific,Corporation (NYSE: BSX ) ... cardioverter defibrillator (ICD). This approval,represents the first Boston ... death (SCD). The CONFIENT ICD, with an ... unnecessary right ventricular pacing. This product also,contains wireless ...
Cached Biology Technology:Nobel Award in Medicine Holds Strong Messsage for Animal Activists 2Salugen to Present at Nutrition Capital Network's First In-Person Investor Meeting 2Boston Scientific Announces European Approval of Next-Generation Implantable Defibrillator 2Boston Scientific Announces European Approval of Next-Generation Implantable Defibrillator 3
Monocarboxylate (lactate) transporter 2...
Chicken Anti-Human Stomatin-like 2 (STOML2 Polyclonal AntibodyNew Applications: ELISA, Western Blot...
MagSi monodispers, magnetic silica particles with modified surface for SO3 coupling chemistry....
Anti-Chicken IgY, (IgG) F(ab')2 Fragment Specific....
Biology Products: