Navigation Links
How do we kill rogue cells?
Date:10/31/2010

A team of Melbourne and London researchers have shown how a protein called perforin punches holes in, and kills, rogue cells in our bodies. Their discovery of the mechanism of this assassin is published today in the science journal Nature.

"Perforin is our body's weapon of cleansing and death," says project leader Prof James Whisstock from Monash University.

"It breaks into cells that have been hijacked by viruses or turned into cancer cells and allows toxic enzymes in, to destroy the cell from within. Without it our immune system can't destroy these cells. Now we know how it works, we can start to fine tune it to fight cancer, malaria and diabetes," he says.

The first observations that the human immune system could punch holes in target cells was made by the Nobel laureate Jules Bordet over 110 years ago. But how?

Researchers from Monash University and the Peter MacCallum Cancer Centre in Melbourne, and Birkbeck College in London collaborated on the ten-year study to unravel the molecular structure and function of perforinthe protein responsible. The structure was revealed with the help of the Australian Synchrotron, and with powerful electron microscopes at Birkbeck. Combining the detailed structure of a single perforin molecule with the electron microscopy reconstruction of a ring of perforins forming a hole in a model membrane reveals how this protein assembles to punch holes in cell membranes.

The new research has confirmed that the important parts of the perforin molecule are quite similar to those in toxins deployed by bacteria such as anthrax, listeria and streptococcus. "The molecular structure has survived for close to two billion years, we think," says Prof Joe Trapani, head of the Cancer Immunology Program at Peter Mac.

"This work is a dramatic illustration of the importance of the synchrotron," says Whisstock. "We simply couldn't have done it without this wonderful facility."

The weapon of death is a
'/>"/>

Contact: Niall Byrne
niall@scienceinpublic.com.au
61-417-131-977
Science in Public
Source:Eurekalert

Page: 1 2

Related biology news :

1. Oregons Rogue River Basin to face climate-change hurdles
2. iGEM team helps prevent rogue use of synthetic biology
3. Does the existing standard of care supply energy sources to brain tumor cells?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/31/2015)... DUBLIN , Aug. 31, 2015 Research ... of the "Saudi Arabia Biomedical Sensors Market - ... offering. The Saudi Arabia Biomedical Sensors ... a CAGR of 3.64% over the period 2014-2020 ... are adaptable to the genetic formulation of each individual. ...
(Date:8/24/2015)... The consulting company Frost & Sullivan ... DERMALOG and its customized solutions and products for ... the Year Award". DERMALOG is particularly successful with a large ... -Cross reference: Picture is available at AP Images ( ... Thursday evening, in South Africa,s economic ...
(Date:8/20/2015)... 2015 NXT-ID, Inc. (NASDAQ: NXTD ) ... on the growing mobile commerce market and creator of ... Smart Card Alliance and the EMV Migration Forum.  ... Smart Card Alliance Latin America (SCALA) Chapter provides NXT-ID, ... thought leaders promoting adoption of smart card technology. ...
Breaking Biology News(10 mins):Saudi Arabia Biomedical Sensors Market Report 2015 - Growth, Trends & Forecasts (2014-2020) 2Frost & Sullivan Honors DERMALOG with Biometrics Prize for Achievements in Africa 2Frost & Sullivan Honors DERMALOG with Biometrics Prize for Achievements in Africa 3NXT-ID, Inc. Joins Smart Card Alliance and EMV Migration Forum 2NXT-ID, Inc. Joins Smart Card Alliance and EMV Migration Forum 3NXT-ID, Inc. Joins Smart Card Alliance and EMV Migration Forum 4
... (self-donated) mononuclear cells derived from bone marrow (BMMNCs) have ... into patients with diabetes who are suffering from critical ... complication of diabetes. The team of researchers in Seville, ... in a recent issue of Cell Transplantation ...
... of Alberta is working with scientists from across North America to ... 15 scientists will examine DNA samples from children with autism and ... risk. , , And if siblings are at high risk ... , If theres a family of a child with autism, they ...
... Boston In a breakthrough for the way brain cancer ... Anna M. Krichevsky, PhD, of the Center of Neurologic Diseases ... Kesari, MD, PhD, director of Neuro-Oncology at UC San Diego ... reliably diagnosed and monitored without surgery. Previously, an accurate ...
Cached Biology News:Autologous bone marrow-derived mononuclear cell transplants can reduce diabetic amputations 2Researchers across North America team up to find genetic markers for autism 2
(Date:9/1/2015)... ... September 01, 2015 , ... Research conducted ... Los Angeles, Boston University School of Medicine, Frederick National Laboratory for Cancer Research, ... world’s first multidisciplinary Open Access journal. , Christopher Ryan PhD, of Synedgen, ...
(Date:8/31/2015)... ... 2015 , ... In recent years, biodegradable plastics have found ... footprints and compostability. These properties can help in limiting the degradation of the ... applications, the market for biodegradable plastics can be broadly segmented into packaging, fibers, ...
(Date:8/31/2015)... , Aug. 31, 2015 Research and ... the "Middle East & Africa Biomedical Sensors Market ... their offering. The Middle ... estimated at $0.84 billion by 2018 at a CAGR ... near future will bring Biomedical sensors that are adaptable ...
(Date:8/31/2015)... and SHANGHAI , ... privately-held biopharmaceutical company developing next-generation antibiotics, today announced ... clinical study for its lead drug candidate MRX-I. ... treat drug-resistant bacteria such as MRSA and VRE, ... better tolerated therapeutic option than currently available oxazolidinone ...
Breaking Biology Technology:Synedgen’s Director for Pharmaceutical Manufacturing Publishes New Research 2Synedgen’s Director for Pharmaceutical Manufacturing Publishes New Research 3Biodegradable Plastics Market Growing at 10.8% CAGR to 2020 2Biodegradable Plastics Market Growing at 10.8% CAGR to 2020 3Biodegradable Plastics Market Growing at 10.8% CAGR to 2020 4Biodegradable Plastics Market Growing at 10.8% CAGR to 2020 5Middle East & Africa Biomedical Sensors Market Report 2015 - Growth, Trends & Forecasts to 2020 2MicuRX Reports Positive Top-Line Results In Phase 2 Clinical Trial For Novel Antibiotic MRX-I In Complicated Skin And Soft Tissue Infections 2
... Health Care Compliance Strategies, Inc. (HCCS) , ... training, today announced the release of a new online ... Associates (BAs) . Responding to expanded HIPAA Privacy Rule ... an online course designed to assist healthcare vendors in ...
... , a venture backed clinical stage biotechnology company developing ... from the Phase 2b trial of ARC-4558 for the ... will be the subject of two poster presentations at ... at the American Diabetes Association,s 71st Scientific Sessions, June ...
... Reportlinker.com announces that a new market research ... Global Immunochemicals Industry ... report analyzes the worldwide markets for Immunochemicals ... segments – Catalog Antibodies, and Custom Antibodies. ...
Cached Biology Technology:New Online Training Course Helps Healthcare Vendors Comply with HIPAA Regulations 2New Online Training Course Helps Healthcare Vendors Comply with HIPAA Regulations 3Arcion Therapeutics to Present ARC-4558 Phase 2b Data for the Treatment of Pain Associated With Painful Diabetic Neuropathy at Upcoming Medical Meetings 2Arcion Therapeutics to Present ARC-4558 Phase 2b Data for the Treatment of Pain Associated With Painful Diabetic Neuropathy at Upcoming Medical Meetings 3Reportlinker Adds Global Immunochemicals Industry 2Reportlinker Adds Global Immunochemicals Industry 3Reportlinker Adds Global Immunochemicals Industry 4Reportlinker Adds Global Immunochemicals Industry 5Reportlinker Adds Global Immunochemicals Industry 6Reportlinker Adds Global Immunochemicals Industry 7Reportlinker Adds Global Immunochemicals Industry 8Reportlinker Adds Global Immunochemicals Industry 9Reportlinker Adds Global Immunochemicals Industry 10
Our Histology, Immunohistochemistry and tissue arrays services include samples processing, different type of staning, histollogical stains, image analysis, tissue arrays, immunohistochemistry, etc....
Mouse monoclonal antibody to PDK2 - pyruvate dehydrogenase kinase, isoenzyme 2...
... of an N-terminal FLAG® fusion and a ... from bicistronic mRNA. Two genes can ... transcription of a single message from the ... protein-protein interaction studies, multi-subunit proteins, and cloning ...
Mouse monoclonal antibody raised against a partial recombinant CALCOCO2. NCBI Entrez Gene ID = CALCOCO2...
Biology Products: