Levels of nitric oxide production may be a key switch triggering how much heat or energy is produced as cells metabolize nutrients, or how much of the nutrients is stored as fat, Lindqvist said.
"At high levels, nitric oxide may inhibit energy production," said Durham University's Andreanna Welch, PhD, first author and a former postdoctoral researcher at UB with Lindqvist. "At more moderate levels, however, it may be more of a tinkering, where nitric oxide is involved in determining whether and when energy or heat is produced."
The research is part of a larger research program devoted to understanding how the polar bear has adapted to the harsh Arctic environment, Lindqvist said.
In 2012, she and colleagues reported sequencing the genomes of multiple brown bears, black bears and polar bears.
In a paper in the Proceedings of the National Academy of Sciences, the team said comparative studies between the DNA of the three species uncovered some distinctive polar bear traits, such as genetic differences that may affect the function of proteins involved in the metabolism of fat a process that's very important for insulation.
In the new study, the scientists looked at the mitochondrial and nuclear genomes of 23 polar bears, three brown bears and a black bear.
|Contact: Charlotte Hsu|
University at Buffalo