Navigation Links
How do cells die? Biophotonic tools reveal real-time dynamics in living color
Date:7/22/2010

Apoptosis, programmed cell death, is essential to normal development, healthy immune system function, and cancer prevention. The process dramatically transforms cellular structures but the limitations of conventional microscopy methods have kept much about this structural reorganization a mystery.

Now, in research featured on the cover of the current issue of Proceedings of the National Academy of Sciences, University at Buffalo scientists have developed a biophotonic imaging approach capable of monitoring in real-time the transformations that cellular macromolecules undergo during programmed cell death.

The work could help realize the potential of customized molecular medicine, in which chemotherapy, for example, can be precisely targeted to cellular changes exhibited by individual patients. It can also be a valuable drug development tool for screening new compounds.

"This new ability provides us with a dynamic mapping of the transformations occurring in the cell at the molecular level," says study co-author Paras N. Prasad, PhD, executive director of the UB Institute for Lasers, Photonics and Biophotonics (ILPB) and SUNY Distinguished Professor in the departments of Chemistry, Physics, Electrical Engineering and Medicine. "It provides us with a very clear visual picture of the dynamics of proteins, DNA, RNA and lipids during the cell's disintegration."

Prasad notes that molecular medicine, in which treatments or preventive measures can be tailored to cellular properties exhibited by individual patients, depends on much better methods of visualizing what's happening during critical cellular processes.

"This research helps improve our understanding of cellular events at the molecular level," he says. "If we know that specific molecular changes constitute an early signature of a disease, or what changes may predispose a patient to that disease, then we can take steps to target treatment or even prevent the di
'/>"/>

Contact: Ellen Goldbaum
goldbaum@buffalo.edu
716-645-4605
University at Buffalo
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Jefferson scientists deliver toxic genes to effectively kill pancreatic cancer cells
2. NSF funds new Center for the Physics of Living Cells at Illinois
3. When cells go bad
4. The role of stem cells in renewing the cornea
5. Breast cancer cells recycle to escape death by hormonal therapy
6. Models of eel cells suggest electrifying possibilities
7. Scientists identify a molecule that coordinates the movement of cells
8. Form of Crohns disease traced to disabled gut cells
9. Cold Spring Harbor Laboratory scientists trace a novel way cells are disrupted in cancer
10. Researchers design artificial cells that could power medical implants
11. Stabilizing force for good communication between neurons and muscle cells found
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
How do cells die? Biophotonic tools reveal real-time dynamics in living color
(Date:4/27/2015)... Apr. 27, 2015 Profile Solutions, Inc. (OTC: ... security systems is pleased to announce that Dr ... consultant and member of its scientific advisory board. ... as a thought leader in technology-enhanced learning models. He ... and has published studies and books focused on online ...
(Date:4/20/2015)... 20, 2015 Huntington Memorial Hospital is the ... a new miniaturized, wireless monitoring sensor to manage heart ... and only FDA-approved heart failure monitoring device that has ... by physicians to manage heart failure. The ... in the pulmonary artery (PA) during a non-surgical procedure ...
(Date:4/17/2015)... 17, 2015 Increasing ... technological advancement to drive biometric systems market in ...   According to a recently released ... &  Opportunities, 2020 ", biometric systems market in ... growth at CAGR of over 22% through 2020. ...
Breaking Biology News(10 mins):Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 2Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 3Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 4Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 2Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 3Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 2Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 3
... an ongoing effort to mirror the ability of biological ... scientists from the McGowan Institute for Regenerative Medicine have ... both biological and chemical toxins. They described the findings ... biological principles to create materials that can do many ...
... University of Florida engineering researchers have found they can ... say opens the door to a wave of new technologies ... about the research appears in this week,s advance online edition ... Ben Koopman and Brij Moudgil say they used lasers not ...
... from the Robertson Foundation to create a state-of-the-art Translational ... cell therapy research and treatment programs for children and ... suffered at birth. In making the announcement, Victor J. ... Chief Executive Officer for Duke University Health System, said ...
Cached Biology News:Multifunctional polymer neutralizes both biological and chemical weapons 2Engineers: Weak laser can ignite nanoparticles, with exciting possibilities 2Engineers: Weak laser can ignite nanoparticles, with exciting possibilities 3Robertson Foundation donates $10.2 million for Duke Cell Therapy Center 2Robertson Foundation donates $10.2 million for Duke Cell Therapy Center 3
(Date:6/1/2015)... Massachusetts , June 1, 2015 ... announces that it will be participating in the Jefferies ... NY on Tuesday, June 2, 2015. ... a question and answer session at 10:00 a.m. ET ... will be available on the Presentations and Webcasts section ...
(Date:6/1/2015)... May 29, 2015 Research and Markets ... the "2015 Strategies in the UK Flow ... This report presents a comprehensive analysis of ... Major issues pertaining to the French flow cytometry ... social and technological trends with significant market impact ...
(Date:6/1/2015)... June 1, 2015 Hutchison ... that AstraZeneca AB (publ) ("AstraZeneca"), Hutchison MediPharma Limited,s ... ongoing Phase Ib clinical trial of HMP,s c-Met ... AZD9291 in non-small cell lung cancer ("NSCLC"). ... epidermal growth factor receptor (EGFR). Preliminary data on ...
(Date:5/31/2015)... (PRWEB) May 31, 2015 The most ... Society of Clinical Oncology (ASCO) Annual Meeting – “The ... Lecture” – prominently featured presentations by immunotherapy experts and ... , James Patrick Allison, PhD, chairman of the Department ... Cancer Center and SITC committee member, received the Science ...
Breaking Biology Technology:Strategies in the UK Flow Cytometry Market 2015 2Savolitinib (AZD6094) Preliminary Phase Ib Clinical Data in Lung Cancer Presented at the 2015 ASCO Annual Meeting 2Savolitinib (AZD6094) Preliminary Phase Ib Clinical Data in Lung Cancer Presented at the 2015 ASCO Annual Meeting 3SITC Reports on Immunotherapy Insights and Data Featured at ASCO Plenary Session 2
... April 28 PharmAthene, Inc. (NYSE Amex: PIP ... threats, today announced the appointment of Mitchel Sayare , Ph.D. ... members. , , ... Dr. Sayare most recently served as Chairman and Chief Executive Officer ...
... ... and Recognition of Science and Technology), a not-for-profit organization founded by inventor Dean Kamen ... Supplier of the FIRST Robotics Competition (FRC®). , ... (PRWEB) April 28, 2010 -- Haydon Kerk Motion Solutions, ...
... Amylin Pharmaceuticals, Inc. (Nasdaq: AMLN ) will be presenting at ... Tuesday, May 4, 2010 at 10:40 a.m. ET / ... chief executive officer of Amylin Pharmaceuticals, will provide a corporate overview. , ... The presentation will be webcast live through the ...
Cached Biology Technology:PharmAthene Appoints Mitchel Sayare, Ph.D. to the Company's Board of Directors 2PharmAthene Appoints Mitchel Sayare, Ph.D. to the Company's Board of Directors 3Haydon Kerk Motion Solutions Inspires Next Generation of Innovators as Silver Supplier of the FIRST Robotics Competition 2Haydon Kerk Motion Solutions Inspires Next Generation of Innovators as Silver Supplier of the FIRST Robotics Competition 3Haydon Kerk Motion Solutions Inspires Next Generation of Innovators as Silver Supplier of the FIRST Robotics Competition 4Amylin Pharmaceuticals to Present at the Deutsche Bank 35th Annual Healthcare Conference 2