Navigation Links
How disordered proteins spread from cell to cell, potentially spreading disease
Date:2/18/2011

ideal for a lot of the standard communication that happens within a cell for its normal functioning, Kopito said.

But if some of our proteins are always disordered, how do our cells tell which proteins need to be properly folded, and which don't? "It's a big mystery," said Kopito, and one that he's studying. This question has implications for how people develop neurodegenerative diseases, all of which appear to be age-related.

Huntington's disease is caused by a specific mutated protein. But the body makes this mutant protein all your life, so why do you get the disease in later adulthood? Kopito said it's because the body's protective mechanisms stop doing their job as we get older. He said his lab hopes to determine what these mechanisms are.

A bad influence

But it's clear what happens when these mechanisms stop working misfolded proteins start recruiting normal versions of the same protein and form large aggregations. The presence of these aggregations in neurons has been closely linked with several neurodegenerative diseases.

Kopito found that the mutant protein associated with Huntington's disease can leave one cell and enter another one, stirring up trouble in each new cell as it progresses down the line. The spread of the misfolded protein may explain how Huntington's progresses through the brain.

This disease, like Parkinson's and Alzheimer's, starts in one area of the brain and spreads to the rest of it. This is also similar to the spread of prions, the self-replicating proteins implicated in mad cow disease and, in humans, Creutzfeldt-Jakob disease. As the misfolded protein reaches more parts of the brain, it could be responsible for the progressive worsening of these diseases.

Now that we know that these misfolded proteins spend part of their time outside of cells, traveling from one cell to another, new drugs could target them there, Kopito said. This could help prevent or at least
'/>"/>

Contact: Louis Bergeron
louisb3@stanford.edu
650-725-1944
Stanford University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Disordered amino acids may really be there to provide wiggle room for signaling protein
2. U of M study identifies risk factors of disordered eating in overweight youth
3. New link between pollution, temperature and sleep-disordered breathing
4. Saliva proteins could help detection of oral cancer
5. New lab manual focuses on essential methods for purifying and characterizing proteins
6. Proteins in sperm unlock understanding of male infertility says new study
7. Linking Proteins, Wires, Dots, and Molecules into Useful Devices
8. Luminescence shines new light on proteins
9. Proteins strangle cell during division
10. Just a little squeeze lets proteins assess DNA
11. New technique is quantum leap forward in understanding proteins
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
How disordered proteins spread from cell to cell, potentially spreading disease
(Date:4/1/2015)... OXFORD, Conn. , Apr. 1, 2015  NXT-ID, ... a biometric authentication company focused on the growing mobile ... number of Wocket smart wallets is underway to early ... early access group includes usage at retail outlets including ... CVS Pharmacy. Users report Wocket was accepted at all ...
(Date:3/31/2015)... 31, 2015   Guidepoint , a leading global ... Post-Surgical Pain Management TRACKER, part of the Guidepoint ... in the medical device and therapeutics markets. The Post-Surgical ... treatment volumes, market share, and adoption rates across three ... joint surgery. The Post-Surgical Pain Management TRACKER ...
(Date:3/24/2015)... Research and Markets ( http://www.researchandmarkets.com/research/hdgz7h/global_iris ) ... Recognition Market 2015-2019" report to their offering. ... to grow at a CAGR of 23.5 percent over ... present scenario and the growth prospects of the Global ... the market size, the report considers the revenue generated ...
Breaking Biology News(10 mins):NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 2NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 3NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 4Guidepoint Launches Post-Surgical Pain Management TRACKER 2Guidepoint Launches Post-Surgical Pain Management TRACKER 3Global Iris Recognition Market 2015-2019 with 3M Cogent, Bioenable Technologies, Cross Match Technology, Iris ID Systems & Safran Dominating 2
... an iconic symbol of America on everything from coins to ... are exploring how the cross-breeding of bison with domestic cattle ... modern populations of the species. "The plains bison are ... survive," said Professor James Derr from Texas A&M University. "The ...
... top national award for promising research scientists has been ... of biology at Rutgers UniversityCamden. Yakoby has received ... The five-year, $686,544 award, which is reviewed and ... project, supports the RutgersCamden researcher,s project "Dynamics and Diversity ...
... 2012  GHX today announced successful results from its ... The company began rolling out the first phase ... sites including both healthcare provider and manufacturer organizations. ... use, GHX believes better management of clinical, operational ...
Cached Biology News:Study reveals impact of historical domestic cattle hybridization with American bison 2Rutgers-Camden genetics researcher receives NSF CAREER Award 2Pilot Results Move GHX Closer to Delivery of Healthcare Industry's First Implantable Device Supply Chain Solution 2Pilot Results Move GHX Closer to Delivery of Healthcare Industry's First Implantable Device Supply Chain Solution 3Pilot Results Move GHX Closer to Delivery of Healthcare Industry's First Implantable Device Supply Chain Solution 4
(Date:5/6/2015)... BETHESDA, Md. , May 6, 2015  Northwest Biotherapeutics ... personalized immune therapies for solid tumor cancers, today announced that ... overview of the Company,s DCVax cancer vaccine platform for solid ... on May 7, 2015.   , ... , , , , TIME: , , , 12:15 ...
(Date:5/6/2015)... Dr Jaspreet Singh , Senior Research ... a speech at the 2015 Asian Starch Conference, to be ... Center.  , ... topic: ,Potato Starch: A Potential Source for the Creation ... Co-editor of a 528 page text book entitled "Advances ...
(Date:5/5/2015)... WARREN, N.J. , May 5, 2015 Roka ... focused on providing advanced testing solutions for the detection of ... will present at the Bank of America Merrill Lynch 2015 ... conference will be held at Encore at the Wynn, ... live webcast of the presentation will be available through the ...
(Date:5/5/2015)... Mass. , May 5, 2015 Psyche ... strategic alliance which offers a first-of-its-kind platform that helps ... access to lab results, transforms the way patients engage ... Luminate Health provides a HIPAA-compliant digital ... to access, manage, and understand their lab results, and ...
Breaking Biology Technology:NW Bio To Webcast, Live, at VirtualInvestorConferences.com On May 7 2NW Bio To Webcast, Live, at VirtualInvestorConferences.com On May 7 3Potato Starch: A Potential Source for the Creation of Next Generation Bulk-ingredients and Smart Foods 2Psyche Systems Corporation Forms Strategic Alliance with Luminate Health to Provide First-of-its-kind Patient Access Solution 2Psyche Systems Corporation Forms Strategic Alliance with Luminate Health to Provide First-of-its-kind Patient Access Solution 3
... available types of synthetic skin may now be good enough ... on their way to truly simulating human skin in the ... to rat skin when they were both exposed to a ... reacted similarly. The scientists used high-resolution images of two ...
... KellBenx, a biotechnology company focused on the development ... disorders, announced today that it has signed an exclusive ... new blood test that could predict the risk of ... women become pregnant. Preterm delivery (PTD) is the leading ...
... Maryland researchers have discovered a way to control magnetic properties ... magnetic storage and magnetic random access memory. The finding ... Michael S. Fuhrer of the UMD Center for Nanophysics and ... for graphene. A honeycomb sheet of carbon atoms just ...
Cached Biology Technology:For testing skin cream, synthetic skin may be as good as the real thing 2For testing skin cream, synthetic skin may be as good as the real thing 3KellBenx Secures Worldwide Agreement With Cedars-Sinai Medical Center for Biomarker Technology to Predict Premature Births 2UMD scientists make magnetic new graphene discovery 2
... Synthesis and Labeling Kit generates labeled cDNA ... unmodified cDNA is made via a reverse ... Oligo(dT) primer. Unlike other methods, there are ... reverse transcription reaction. This unmodified cDNA is ...
The Piezo Power MicroDissection (PPMD) system is designed for rapid isolation of single cells or small cell areas...
... specifically for Alkaline Phosphatase conjugates. The ... for both the enzyme and the antibody ... This product has been chemically engineered to ... longer shelf life, resistance to various shipping ...
AC input: 50-60 Hz230 V...
Biology Products: