Navigation Links
How disordered proteins spread from cell to cell, potentially spreading disease
Date:2/18/2011

ideal for a lot of the standard communication that happens within a cell for its normal functioning, Kopito said.

But if some of our proteins are always disordered, how do our cells tell which proteins need to be properly folded, and which don't? "It's a big mystery," said Kopito, and one that he's studying. This question has implications for how people develop neurodegenerative diseases, all of which appear to be age-related.

Huntington's disease is caused by a specific mutated protein. But the body makes this mutant protein all your life, so why do you get the disease in later adulthood? Kopito said it's because the body's protective mechanisms stop doing their job as we get older. He said his lab hopes to determine what these mechanisms are.

A bad influence

But it's clear what happens when these mechanisms stop working misfolded proteins start recruiting normal versions of the same protein and form large aggregations. The presence of these aggregations in neurons has been closely linked with several neurodegenerative diseases.

Kopito found that the mutant protein associated with Huntington's disease can leave one cell and enter another one, stirring up trouble in each new cell as it progresses down the line. The spread of the misfolded protein may explain how Huntington's progresses through the brain.

This disease, like Parkinson's and Alzheimer's, starts in one area of the brain and spreads to the rest of it. This is also similar to the spread of prions, the self-replicating proteins implicated in mad cow disease and, in humans, Creutzfeldt-Jakob disease. As the misfolded protein reaches more parts of the brain, it could be responsible for the progressive worsening of these diseases.

Now that we know that these misfolded proteins spend part of their time outside of cells, traveling from one cell to another, new drugs could target them there, Kopito said. This could help prevent or at least
'/>"/>

Contact: Louis Bergeron
louisb3@stanford.edu
650-725-1944
Stanford University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Disordered amino acids may really be there to provide wiggle room for signaling protein
2. U of M study identifies risk factors of disordered eating in overweight youth
3. New link between pollution, temperature and sleep-disordered breathing
4. Saliva proteins could help detection of oral cancer
5. New lab manual focuses on essential methods for purifying and characterizing proteins
6. Proteins in sperm unlock understanding of male infertility says new study
7. Linking Proteins, Wires, Dots, and Molecules into Useful Devices
8. Luminescence shines new light on proteins
9. Proteins strangle cell during division
10. Just a little squeeze lets proteins assess DNA
11. New technique is quantum leap forward in understanding proteins
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
How disordered proteins spread from cell to cell, potentially spreading disease
(Date:7/29/2014)... of Dentistry (UM SOD) and Medicine (UM SOM) ... five-year $10.7 million grant award from the National ... the National Institutes of Health to study the ... The grant, which renews a previous $12 million ... for the research by studying chlamydial and gonorrheal ...
(Date:7/29/2014)... two of the major disciplines behind Jurassic Park is ... stunning photographs and unique illustrations. , Fossil Insects, by ... incredible preservation and diversity of fossilised insects from around ... fossils can tell us about the ancient and modern ... the mosquito in Jurassic Park, many of the hundreds ...
(Date:7/28/2014)... additional coral communities showing signs of damage from the Deepwater ... spill in the Gulf of Mexico. The discovery was made ... at Penn State University. A paper describing this work and ... of Mexico will be published during the last week of ... Proceedings of the National Academy of Sciences . , ...
Breaking Biology News(10 mins):University of Maryland Schools of Dentistry and Medicine receive NIH grant 2University of Maryland Schools of Dentistry and Medicine receive NIH grant 3University of Maryland Schools of Dentistry and Medicine receive NIH grant 4Unique images bring fossil insects back to life 2Impact of Deepwater Horizon oil spill on coral is deeper and broader than predicted 2
... have found that winter precipitation such as rain and ... last 100 years. Similar increases in heavy rainfall have ... extent, autumn. A previously reported reduction in heavy summer ... for the last decade indicating a return to more typical ...
... have started to evaluate the use of fully human ... against a variety of diseases. The most obvious advantage ... immune system that typically characterizes the use of chemerical ... and the potential benefits, the efficient production of human ...
... CAMBRIDGE, Mass. Researchers in Civil and Environmental Engineering ... material like spider silk lies in the specific geometric ... weak hydrogen bonds that work cooperatively to resist force ... natural material as strong as steel, even though the ...
Cached Biology News:Heavy rainfall on the increase 2Is hybridoma production about to take a quantum leap forward? 2Is hybridoma production about to take a quantum leap forward? 3Is hybridoma production about to take a quantum leap forward? 4Protein's strength lies in h-bond cooperation 2Protein's strength lies in h-bond cooperation 3
(Date:7/29/2014)... (PRWEB) July 29, 2014 July ... vaccine pioneer in the biotechnology industry, announced that ... Coast Securities, Inc. to explore financing opportunities that ... technology, a breakthrough vaccine platform with the potential ... The company exclusively licensed the well-established LAMP platform ...
(Date:7/29/2014)... Genera Energy Inc. , ... and supply chain advancements, has announced the deployment ... Grange™ and Supply ASSURE™. Both systems were ... aimed at consolidating and simplifying the entire process, ... and feedstock end users. , “Through the Energy ...
(Date:7/29/2014)... July 29, 2014 DisasterTalk is a texting ... where cell phone masts or other transmitters are down. The ... feet away without the need for any Wi-Fi, and can ... , The new app has launched as a housing ... at very high risk of being affected by natural disasters. ...
(Date:7/29/2014)... SPRING, Md., July 29, 2014  United Therapeutics ... announced its financial results for the second ... continued growth shows that our medicines are ... pulmonary arterial hypertension (PAH)," said Martine Rothblatt, ... Officer. "The commercial launch this quarter of ...
Breaking Biology Technology:Immunomic Therapeutics Engages Newport Coast Securities, Inc. 2Immunomic Therapeutics Engages Newport Coast Securities, Inc. 3Genera Energy Introduces Proprietary Feedstock Management Systems 2Genera Energy Introduces Proprietary Feedstock Management Systems 3Genera Energy Introduces Proprietary Feedstock Management Systems 4DisasterTalk App Could Save Lives as Report Reveals 8% of US Homes at Very High Risk of Natural Disaster 2United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 2United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 3United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 4United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 5United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 6United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 7United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 8United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 9United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 10United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 11United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 12United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 13
... free to do what I want any old time. ... ,Lately, I've been hearing this old Rolling Stones standard from ... some brand of financial services targeted at Boomers with bloated ... this ad is aimed at helping people achieve their retirement ...
... For the second consecutive year, the City of ... digitized and online-accessible municipalities in the country. , ,In its ... Government , a national research and advisory institute on information ... the city as the top user of technology in its ...
... enter contests to win prizes, and the Wisconsin Governor's ... About $450,000 in cash and in-kind prizes have been awarded ... prize in this statewide contest is unofficial: The chance to ... birth in 2004, the Governor's Business Plan Contest has helped ...
Cached Biology Technology:Can a talent market work inside organizations? 2Can a talent market work inside organizations? 3Can a talent market work inside organizations? 4Can a talent market work inside organizations? 5Can a talent market work inside organizations? 6Business Plan Contest produces successful grads 2Business Plan Contest produces successful grads 3
ATGL Antibody Shipping Temperature: HOT Storage Temperature: -20C...
Human sIL-2R/CD25 ELI-PAIR Kit...
Rabbit polyclonal to Factor IX ( Abpromise for all tested applications). entrezGeneID: 2158 SwissProtID: P00740...
Rabbit polyclonal to Phosphothreonine-Proline / Phosphoserine-Proline ( Abpromise for all tested applications)....
Biology Products: