Navigation Links
How disordered proteins spread from cell to cell, potentially spreading disease
Date:2/18/2011

One bad apple is all it takes to spoil the barrel. And one misfolded protein may be all that's necessary to corrupt other proteins, forming large aggregations linked to several incurable neurodegenerative diseases such as Huntington's, Parkinson's and Alzheimer's.

Stanford biology Professor Ron Kopito has shown that the mutant, misfolded protein responsible for Huntington's disease can move from cell to cell, recruiting normal proteins and forming aggregations in each cell it visits.

Knowing that this protein spends part of its time outside cells "opens up the possibility for therapeutics," he said. Kopito studies how such misfolded proteins get across a cell's membrane and into its cytoplasm, where they can interact with normal proteins. He is also investigating how these proteins move between neuronal cells.

The ability of these proteins to move from one cell to another could explain the way Huntington's disease spreads through the brain after starting in a specific region. Similar mechanisms may be involved in the progress of Parkinson's and Alzheimer's through the brain.

Kopito discussed his research on Friday, Feb. 18, at 8:00 a.m. Eastern, at the annual meeting of the American Association for the Advancement of Science in Washington, D.C.

Not all bad

Not all misfolded proteins are bad. The dogma used to be that all our proteins formed neat, well-folded structures, packed together in complexes with a large number of other proteins, Kopito said. But over the past 20 years, researchers have found that as much as 30 percent of our proteins never fold into stable structures. And even ordered proteins appear to have some disordered parts.

Disordered proteins are important for normal cellular functions. Unlike regular proteins, they only interact with one partner at a time. But they are much more dynamic, capable of several quick interactions with many different proteins. This makes them
'/>"/>

Contact: Louis Bergeron
louisb3@stanford.edu
650-725-1944
Stanford University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Disordered amino acids may really be there to provide wiggle room for signaling protein
2. U of M study identifies risk factors of disordered eating in overweight youth
3. New link between pollution, temperature and sleep-disordered breathing
4. Saliva proteins could help detection of oral cancer
5. New lab manual focuses on essential methods for purifying and characterizing proteins
6. Proteins in sperm unlock understanding of male infertility says new study
7. Linking Proteins, Wires, Dots, and Molecules into Useful Devices
8. Luminescence shines new light on proteins
9. Proteins strangle cell during division
10. Just a little squeeze lets proteins assess DNA
11. New technique is quantum leap forward in understanding proteins
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
How disordered proteins spread from cell to cell, potentially spreading disease
(Date:10/18/2014)... patients referred for evaluation of suspected genetic conditions, ... 25 percent, including detection of a number of ... disease, according to a study appearing in ... coincide with the American Society of Human Genetics ... or coding regions of thousands of genes simultaneously ...
(Date:10/17/2014)... news release is available in German . ... millions of sperms every day in order to reproduce? And ... are the topic of the latest issue of the research ... 2014). The evolutionary biologist Steven Ramm from Bielefeld University Bielefeld ... it is not unusual for a female to copulate with ...
(Date:10/16/2014)... constantly wages war on the human body. Battles ... stalemate. In pancreatic cancer, this stalemate—known as tumor ... aggressively malignant, a phenomena that is poorly understood. ... the laboratory of Salvatore Torquato, a Professor of ... conditions surrounding tumor dormancy and the switch to ...
Breaking Biology News(10 mins):Whole-exome sequencing shows potential as diagnostic tool 2Sperm wars 2Modeling tumor dormancy 2
... chemical processes in cells is dictated by the speed of ... a versatile method developed at the Institute of Physical Chemistry ... able to predict for the first time the diffusion coefficients ... is important not only for biologists and chemists, but also ...
... the first medication approved for the treatment of alcoholism ... part, by preventing the metabolism of an alcohol by-product, ... cause unpleasant symptoms, including nausea, vomiting, headache, and accelerated ... to avoid drinking. Beginning in the late ...
... alone were responsible for the demise of Australia,s iconic ... new study led by the University of Adelaide has ... study contradicts the widespread belief that disease must have ... thylacine was a unique marsupial carnivore found throughout most ...
Cached Biology News:Biologistics: How fast do chemical trains move in living cells? 2Biologistics: How fast do chemical trains move in living cells? 3Disulfiram: New support for an old addiction drug 2Disease not a factor in Tassie Tiger extinction 2
(Date:10/22/2014)... 2014 Research and Markets ... DNA Diagnostics Market (Product types, Application, Technology, End ... Company Profiles, Demand, Insights, Analysis, Research, Report, Opportunities, ... to their offering. This new ... end users and Geography) Global Size, Industry Analysis, ...
(Date:10/22/2014)... Involution Studios , a healthcare software ... infographic, Understanding Ebola . The goal of ... to follow informative tool for anyone wanting to know ... prevention. , "As the news has spread in all ... represents not only a healthcare crisis with global impact, ...
(Date:10/22/2014)... (PRWEB) October 22, 2014 According ... Market by Service Type (Consulting, Integration, Deployment & ... by Deployment Model (Public, Private, Others (Hybrid & ... MarketsandMarkets, defines and segments the Cloud Professional Services ... and forecasting of revenues. It also identifies the ...
(Date:10/22/2014)... DIEGO and HONG KONG ... innovative rare disease therapeutics enterprise, announced today that rare ... the company as vice president, research. Dr. McKew brings ... including key leadership positions at the National Institutes of ... its acquisition by Wyeth). Dr. McKew will lead aTyr,s efforts ...
Breaking Biology Technology:Global DNA Diagnostics Market (Product types, Application, Technology, End User and Geography) - Forecast to 2020 2Global DNA Diagnostics Market (Product types, Application, Technology, End User and Geography) - Forecast to 2020 3Involution Studios' Ebola Infographic Provides Key Disease Information and Statistics at a Glance 2Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 2Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 3Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 4Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 5aTyr Pharma Appoints John C. McKew, Ph.D., as Vice President, Research 2aTyr Pharma Appoints John C. McKew, Ph.D., as Vice President, Research 3
... revenue growth ... Q3 2008 Highlights: - Product revenues ... - Direct (Non-OEM) Business revenues increased by 48% ... Calif., Oct. 27 Masimo Corporation,(Nasdaq: MASI ), the inventor of Pulse ...
... as Lead Epidemiologist, RALEIGH, N.C., Oct. 27 ... today the appointment of Dr.,Jerome Wilson as Senior ... Epidemiologist, Dr. Wilson is responsible for providing consulting,services ... PRA provides extensive Phase IV Post-Marketing services to,pharmaceutical ...
... JOSE, Calif., Oct. 27 HPSI (OTC Bulletin,Board: EROX) releases ... light of events that have shaken the investment community around ... to take this opportunity to update you as to ... Excluding technology advancements, an update of which will be ...
Cached Biology Technology:Masimo Reports Third Quarter 2008 Financial Results 2Masimo Reports Third Quarter 2008 Financial Results 3Masimo Reports Third Quarter 2008 Financial Results 4Masimo Reports Third Quarter 2008 Financial Results 5Masimo Reports Third Quarter 2008 Financial Results 6Masimo Reports Third Quarter 2008 Financial Results 7Masimo Reports Third Quarter 2008 Financial Results 8Masimo Reports Third Quarter 2008 Financial Results 9Masimo Reports Third Quarter 2008 Financial Results 10Masimo Reports Third Quarter 2008 Financial Results 11Masimo Reports Third Quarter 2008 Financial Results 12Masimo Reports Third Quarter 2008 Financial Results 13Jerome Wilson Joins PRA International's Late Phase Service Group 2Human Pheromone Sciences, Inc. - Shareholder Update 2Human Pheromone Sciences, Inc. - Shareholder Update 3
... Microarray Dot Blot Kits overcome this limitation ... over a wide range in low-density protein ... They are ideal for performing reverse-phase ... samples for the presence of low abundant ...
... easy-to-use kits for arraying proteins of ... common lab equipment. DiscoverLight Protein Array ... your protein, cell lysate or antibody ... kits include specially designed nitrocellulose membranes ...
Request Info...
... StabilZyme AP Conjugate Stabilizer is an ... bovine protein and other non-toxic stabilizing ... acid), pH 5.5 6.5. ... 0.02% methylisothiazolone and 0.02% bromonitrodioxane as ...
Biology Products: