Navigation Links
How did chemical constituents essential to life arise on primitive Earth?
Date:10/30/2007

Experiments show that simple molecules can combine chemically rather than biologically to form the building blocks of DNA, the key component of all life forms. These processes might have taken place on primitive earth, but how they occur is an unsolved puzzle.

Chemists at the University of Georgia have now proposed the first detailed, feasible mechanism to explain how adenine, one of the four building blocks of DNA, might be built up from the combination of five cyanide molecules. The investigation is based on extensive quantum chemical computations over several years.

Just where these biomolecules originated isnt known, said Paul von Ragu Schleyer, Graham Perdue Professor of Chemistry at the University of Georgia. One can only speculate. They could have formed from smaller molecules present on primitive Earth, either very slowly over millions of years or rapidly before the Earth cooled down. Asteroids may have brought them from outer space, but how did biomolecules form there"

The newly proposed mechanism for the formation of adenine gives a clear picture of how it could have become one of the building blocks essential for the formation of DNA. The research was published today in the print version of the Proceedings of the National Academies of Science. Schleyers coworkers were Ph. D. candidate Debjani Roy, the first author of the paper, and Katayoun Najafian, his former student from Iran.

DNA is the nucleic acid blueprint of life that is passed on from generation to generation. First isolated in 1869 from the pus of discarded surgical bandages by Friedrich Miescher, a Swiss doctor, DNAs double helix structure was solved by Watson and Crick in 1953. DNA is shaped somewhat like a twisted ladder with the rungs anchored by matching pairs of only four bases: adenine, guanine, cytosine and thymine.

The UGA chemists focused on adenine because of its relative prevalence on Earth and its formation in the dark in from simple components. Along with other fundamental building blocks, adenine has even been detected extraterrestrially. Still, the vast distance between the smaller molecules required to form adenine in outer space precludes its formation, unless some nucleation centers, like specks of interstellar dust, are present.

Numerous experiments have demonstrated that amino acids, nucleotides, carbohydrates and other essential compounds form under simulated primitive Earth conditions, the authors write in their paper.

Remarkably, a solution of highly poisonous cyanide in ammonia, frozen solid in a refrigerator for 25 years, produced adenine, a necessary component of life. A substantial amount of adenine also was formed in a high-temperature experiment designed to simulate early volcano-like environments. But the question is how.

The Georgia researchers arrived at an answer by solving a series of key riddles. They worked out the processes in which five cyanide molecules might combine to form adenine under terrestrial conditions. Their predictions are based on extensive computations of sequences of reaction steps along possible mechanistic routes.

Finding a viable, thermodynamically feasible, step-by-step mechanism that can account for the formation of adenine was far from straightforward, the authors said. Our report provides a more detailed understanding of some of the chemical process involved in chemical evolution, and a partial answer to the fundamental question of molecular biogenesis. Our investigation should trigger similar investigations of the abiotic formation of the remaining nucleic acid bases as well as other biologically relevant molecules.


'/>"/>

Contact: Kim Osborne
kosborne@uga.edu
706-583-0913
University of Georgia
Source:Eurekalert

Related biology news :

1. BRCA1 causes ovarian cancer through indirect, biochemical route
2. Study shows nanoshells ideal as chemical nanosensors
3. MSI releases moleculizer - a new approach to simulation of intracellular biochemical networks
4. Researchers discover chemical compounds that affect plant growth
5. Chemicals in tattoo inks need closer scrutiny
6. Harmful chemicals may reprogram gene response to estrogen
7. Disease diagnosis, biodefense among UH chemical research projects
8. Roots Engage in Underground Chemical Warfare
9. NYU and MSKCC research provides model for understanding chemically induced cancer initiation
10. Could microbes solve Russias chemical weapons conundrum?
11. Two chemicals boost immune cells ability to fight HIV without gene therapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/6/2017)... LONDON , April 6, 2017 ... Control, RFID, ANPR, Document Readers, by End-Use (Transportation & ... Energy Facility, Oil, Gas & Fossil Generation Facility, Nuclear ... Healthcare, Educational, Other) Are you looking for ... Authentication sector? ...
(Date:4/5/2017)... April 4, 2017 KEY FINDINGS ... expand at a CAGR of 25.76% during the forecast ... the primary factor for the growth of the stem ... https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The global stem cell ... application, and geography. The stem cell market of the ...
(Date:3/30/2017)... March 30, 2017  On April 6-7, 2017, Sequencing.com ... Genome hackathon at Microsoft,s headquarters in ... will focus on developing health and wellness apps that ... Hack the Genome is the first hackathon for ... world,s largest companies in the genomics, tech and health ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... and LAGUNA HILLS, Calif. , Oct. 11, ... Research, London (ICR) and University of ... SkylineDx,s prognostic tool to risk-stratify patients with multiple myeloma (MM), ... nine . The University of Leeds ... funded by Myeloma UK, and ICR will perform the testing ...
(Date:10/11/2017)... ... 11, 2017 , ... Singh Biotechnology today announced that the ... its novel anti-STAT3 (Signal Transducer and Activator of Transcription 3) B VHH13 single ... the cell membrane and bind intracellular STAT3 and inhibit its function. Dysregulation of ...
(Date:10/10/2017)... Philadelphia, PA (PRWEB) , ... October 10, 2017 ... ... University City Science Center’s FirstHand program has won a US2020 STEM Mentoring Award. ... accept the award for Excellence in Volunteer Experience from US2020. , US2020’s mission ...
(Date:10/10/2017)... SomaGenics announced the receipt of a Phase ... (Single Cell), expected to be the first commercially available ... from single cells using NGS methods. The NIH,s recent ... development of approaches to analyze the heterogeneity of cell ... for measuring levels of mRNAs in individual cells have ...
Breaking Biology Technology: