Navigation Links
How chronic obstructive pulmonary disease increases risk of lung cancer
Date:7/24/2012

aling by HIF-2a. This HIF-2a in turn activates cancer growth promoting mechanisms including VEGF and the EGFR ligand, TGFa, which are growth factors involved in stimulating cell proliferation and the development of new blood vessels," Miller says.

Likewise, just as tumors that arise in hypoxic conditions do so through turning on pathways that lead to the over-production of VEGF and TGFa, so too are these tumors especially susceptible to cancer therapies that block these growth factors. Sure enough, animal models given the drug vandetanib a combined VEGFR/EGFR inhibitor failed to develop cancer under hypoxic conditions.

"Chemoprevention hasn't been done successfully for lung cancer," Miller says, "but this approach of VEGF/EGFR inhibitors for patients with COPD and extreme lung cancer risk may be something that should be explored further."

Miller imagines the next step is a review of patient records to discover if COPD lung cancer patients who happened to be treated with VEGF/EGFR inhibitors, in fact, had better tumor response than patients with normal lung function and similar tumors.

"Right now it's not a treatment," Miller says, "but it's an exciting line of inquiry."


'/>"/>

Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver
Source:Eurekalert

Page: 1 2

Related biology news :

1. Genetic mutation found in familial chronic diarrhea syndrome
2. Effect of chronic exposure to chemicals used as weapons, pesticides under study
3. BYU engineers conceive disc replacement to treat chronic low back pain
4. Neuroprotective dietary supplements for chronic spinal cord injury
5. Why chronic pain is all in your head
6. Chronic inflammation in the brain leads the way to Alzheimers disease
7. miR loss may power maligant transformation in chronic leukemia
8. Obstructive sleep apneas damage evident after 1 month
9. Researchers identified a protein useful in predicting the risk of pulmonary metastases in breast cancer patients
10. Researchers find critical regulator to tightly control deadly pulmonary fibrosis
11. Parkinsons disease stopped in animal model
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... Canyon fire started near the City of Entiat on ... resources, the fire quickly grew to over 1,000 acres ... the fire is under investigation by the Washington Department ... with existing local resources in developing fire control strategies ... (USFS), Washington State Department of Natural Resources, (WA DNR), ...
(Date:7/11/2014)... Cell scientists have set a "mouse TRAP" to capture ... a recent study published in the Journal of ... a technique called TRAP to extract cellular and genetic ... by scientists at the Rockefeller Institute for Medical Research ... the protein-making machinery, or ribosomes, of the cell type ...
(Date:7/11/2014)... develop relationships with other group members to reduce aggression ... baboons the strategy for grooming activities shows a certain ... in the scientific journal Biology Letters . , ... not practiced without ulterior motives. To be groomed has ... while grooming another individual can provide access to infants, ...
Breaking Biology News(10 mins):Baboons groom early in the day to get benefits later 2
... The entire Hawaiian population of the peat moss Sphagnum ... in existence for some 50,000 years researchers have discovered. The ... the most long-lived of organisms, every plant of the Hawaiian ... sexual propagation and can be traced back to a single ...
... up the process of officially recognizing new plant species, ... descriptions of new species, and publication in online academic ... print publication. The new rules, which were approved ... International Botanical Congress in July, become effective January 1, ...
... University of California, Riverside scientists released a natural enemy ... campus to help control the spread of the psyllid, an ... industry and citrus trees in home landscapes. This is the ... California. UC Riverside Executive Vice Chancellor Dallas Rabenstein ...
Cached Biology News:Ave Atque Vale: Botany bids 'hail and farewell' to Latin-only descriptions in 2012 2Ave Atque Vale: Botany bids 'hail and farewell' to Latin-only descriptions in 2012 3UC Riverside scientists release natural enemy of Asian citrus psyllid 2UC Riverside scientists release natural enemy of Asian citrus psyllid 3UC Riverside scientists release natural enemy of Asian citrus psyllid 4
(Date:7/11/2014)... /CNW/ - Sunovion Pharmaceuticals Canada Inc. (Sunovion) today announced ... for use as a once-daily adjunctive therapy for the ... are not satisfactorily controlled with conventional therapy.  APTIOM TM ... 18 years of age. Epilepsy is ... to Epilepsy Canada, it affects 0.6% of the population ...
(Date:7/10/2014)... (PRWEB) July 10, 2014 Women ... have access to an additional family planning option. ... to contraception at all levels of the health ... formulation of a widely used contraceptive—Pfizer’s Depo-Provera® (depot ... Burkina Faso is the first of four African ...
(Date:7/10/2014)... Cleveland, Ohio (PRWEB) July 10, 2014 ... in ion channel-expressing cell lines, and the gap that ... new cells that expand its industry-leading portfolio of validated ... focuses on ion channel-expressing cell lines, as ion channels ... able to control this activity creates the potential to ...
(Date:7/10/2014)... July 10, 2014 Robert Harman, DVM, Founder ... company, is proud to announce the relaunch of his highly ... a new series called “ What are Stem Cells ?” ... honest and straightforward foundation in the basics of stem cell ... on the right type of treatment when considering regenerative medicine. ...
Breaking Biology Technology:Sunovion Pharmaceuticals Canada Inc. Announces Health Canada Approval of APTIOM(TM) (eslicarbazepine acetate) as a Once-Daily Adjunctive Treatment for Partial-Onset Seizures in Patients with Epilepsy 2Sunovion Pharmaceuticals Canada Inc. Announces Health Canada Approval of APTIOM(TM) (eslicarbazepine acetate) as a Once-Daily Adjunctive Treatment for Partial-Onset Seizures in Patients with Epilepsy 3Sunovion Pharmaceuticals Canada Inc. Announces Health Canada Approval of APTIOM(TM) (eslicarbazepine acetate) as a Once-Daily Adjunctive Treatment for Partial-Onset Seizures in Patients with Epilepsy 4Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 2Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 3Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 4Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 5Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 6Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 2Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 3Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 2Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 3
... 3-4 in Milwaukee, is being organized by the ... Wisconsin Innovation Network . Organizers plan to turn the ... and other representatives of emerging technology companies the opportunity ... - if they only could find the right ideas ...
... techniques, such as off-site tape rotation, can require ... Ready Recovery provides nearly real-time recovery using high-availability ... of Berbee. , ,In addition, Berbee offers custom-built ... customer implementations. This solution can help organizations reduce ...
... of training is discussed with small companies and startups, ... phase. Training should be the cornerstone of any companys ... Cisco Systems, Intel, etc., training takes priority in these ... quickly your skill sets can become obsolete just as ...
Cached Biology Technology:Connecting Investment Capital with Entrepreneurs: Investors to lay out what theyre looking for in startup companies 2The Big Differentiator, Training! 2
... data collection and automation that is controlled from ... Excel , Pre-configured library of interfaces for ... can be added and configured by the user ... into one spreadsheet , Allows for ...
...
Peptide-affinity Purified Polyclonal Antibody to MAML1 / Mastermind Peptide with sequence VLPTCPMAEFALPR, from N Terminus of the protein sequence according to NP_055572....
One unit is equal to 10Kb (insert DNA + vector). The final cost will increase or decrease according to the final assembled genome size. The price does not include genome annotation....
Biology Products: