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How cells brace themselves for starvation
Date:2/22/2012

Sugar, cholesterol, phosphates, zinc a healthy body is amazingly good at keeping such vital nutrients at appropriate levels within its cells. From an engineering point of view, one all-purpose model of pump on the surface of a cell should suffice to keep these levels constant: When the concentration of a nutrient, say, sugar, drops inside the cell, the pump mechanism could simply go into higher gear until the sugar levels are back to normal. Yet strangely enough, such cells let in their nutrients using two types of pump: One is active in "good times," when a particular nutrient is abundant in the cell's environment; the other is a "bad-times" pump that springs into action only when the nutrient becomes scarce. Why does the cell need this dual mechanism?

A new Weizmann Institute study, reported in Science, might provide the answer. The research was conducted in the lab of Prof. Naama Barkai of the Molecular Genetics Department by postdoctoral fellow Dr. Sagi Levy and graduate student Moshe Kafri with lab technician Miri Carmi.

It had been known for a while that when the levels of phosphate or zinc drop in the surroundings of a yeast cell, the number of "bad-times" pumps on the cell surface soars up to a hundred-fold. When phosphate or zinc becomes abundant again, the "bad-times" pumps withdraw while the "good-times" pumps return to the cell surface in large numbers.

In their new study, the scientists discovered that cells which repress their "bad-times" pumps when a nutrient is abundant were much more efficient at preparing for starvation and at recovering afterwards than the cells that had been genetically engineered to avoid this repression. The conclusion: The "good-times" pumps apparently serve as a signaling mechanism that warns the yeast cell of approaching starvation. Such advance warning gives the cell more time to store up on the scarce nutrient; the thorough preparation also helps the cell to start growing faster
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Contact: Yivsam Azgad
news@weizmann.ac.il
972-893-43856
Weizmann Institute of Science
Source:Eurekalert

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