Navigation Links
How brain microcircuits integrate information from different senses
Date:8/20/2013

A new publication in the top-ranked journal Neuron sheds new light onto the unknown processes on how the brain integrates the inputs from the different senses in the complex circuits formed by molecularly distinct types of nerve cells. The work was led by new Ume University associate professor Paolo Medini.

One of the biggest challenges in Neuroscience is to understand how the cerebral cortex of the brain processes and integrates the inputs from the different senses (like vision, hearing and touch) to control for example, that we can respond to an event in the environment with precise movement of our body.

The brain cortex is composed by morphologically and functionally different types of nerve cells, e.g. excitatory, inhibitory, that connect in very precise ways. Paolo Medini and co-workers show that the integration of inputs from different senses in the brain occurs differently in excitatory and inhibitory cells, as well as in superficial and in the deep layers of the cortex, the latter ones being those that send electrical signals out from the cortex to other brain structures.

"The relevance and the innovation of this work is that by combining advanced techniques to visualize the functional activity of many nerve cells in the brain and new molecular genetic techniques that allows us to change the electrical activity of different cell types, we can for the first time understand how the different nerve cells composing brain circuits communicate with each other", says Paolo Medini.

The new knowledge is essential to design much needed future strategies to stimulate brain repair. It is not enough to transplant nerve cells in the lesion site, as the biggest challenge is to re-create or re-activate these precise circuits made by nerve cells.

Paolo Medini has a Medical background and worked in Germany at the Max Planck Institute for Medical Research of Heidelberg, as well as a Team leader at the Italian Institute of Technology in Genova, Italy. He recently started on the Associate Professor position in Cellular and Molecular Physiology at the Molecular Biology Department.

He is now leading a brand new Brain Circuits Lab with state of state-of-the-art techniques such as two-photon microscopy, optogenetics and electrophysiology to investigate the circuit functioning and repair in the brain cortex. This investment has been possible by a generous contribution from the Kempe Foundation and by the combined effort of Ume University.

"By combining cell physiology knowledge in the intact brain with molecular biology expertise, we plan to pave the way for this kind of innovative research that is new to Ume University and nationally", says Paolo Medini.


'/>"/>

Contact: Paolo Medini
paolo.medini@molbiol.umu.se
46-907-856-742
Umea University
Source:Eurekalert

Related biology news :

1. REST is crucial for the timing of brain development
2. Holding a mirror to brain changes in autism
3. Strong scientific evidence that eating berries benefits the brain
4. The Japanese traditional therapy, honokiol, blocks key protein in inflammatory brain damage
5. Step forward in research into new treatments for brain edema
6. University of Alberta led research may have discovered how memories are encoded in our brains
7. Nanotherapy: Treating deadly brain tumors by delivering big radiation with tiny tools
8. Friendly to a fault, yet tense: Personality traits traced in brain
9. New discoveries about brain-hand connection sought to improve therapies, treatments, prosthetics
10. Autism risk gene linked to differences in brain structure
11. Amyloid beta in the brain of individuals with Alzheimers disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/21/2017)... Research and Markets has announced the addition of the ... ... voice recognition biometrics market to grow at a CAGR of 19.36% ... present scenario and the growth prospects of the global voice recognition ... considers the revenue generated from the sales of voice recognition biometrics ...
(Date:1/13/2017)... , Jan. 13, 2017 Sandata Technologies, ... for the homecare industry, including Electronic Visit Verification™ ... expert, Justin Jugs, as Senior Vice President of ... 15 years of homecare experience to Sandata, where ... strategic plans to align Sandata,s suite of solutions ...
(Date:1/11/2017)... NEW BRUNSWICK, N.J. , Jan. 11, 2017  Michael Johnson, ... from Foundation Venture Capital Group, Inc., has been named to the ... Johnson, 27,  was one of 600 people in 20 fields ... only four percent of the 15,000 applicants were selected. ... He is currently a PhD ...
Breaking Biology News(10 mins):
(Date:1/24/2017)... Calif. , Jan. 24, 2017  Frost & Sullivan is ... the Fonar Corporation, will receive special recognition at the 22nd ... place March 19 to 21, 2017 at the Loews Coronado Bay ... To register and download the event agenda for Medical Technologies ... ...
(Date:1/24/2017)... , Jan. 24, 2017   Bracket , a ... announced the addition of Jennifer Peters to ... President and General Manager for the Scientific Services division. ... Bracket,s work in Rater Training, Quality Assurance, and Electronic ... a strong skillset and demonstrated record building technology-based businesses ...
(Date:1/24/2017)... Inc. (NYSE: BIOA ) announced that, due to ... of the offering by 75% and purchase 3,684,212 shares of ... 1,842,106 shares of common stock of the Company with an ... "Exercise Price"), at a price to the public of US$4.75 ... have a term of four (4) years, exercisable upon the ...
(Date:1/24/2017)... (PRWEB) , ... January 24, 2017 , ... ... of label-free graphene biosensor assays for fragment-based screening, will showcase its ... 2017 Society for Laboratory Automation and Screening (SLAS) conference in Washington, D.C. from ...
Breaking Biology Technology: