Navigation Links
How body size is regulated
Date:5/9/2008

This meta-analysis, published in the latest issue of Nature Genetics, is based on data from more than 26,000 study participants. It verifies two already known genes, but also discovered ten new genes. Altogether they explain a difference in body size of about 3.5 centimeters.

The analysis produced some biologically insightful findings. Several of the identified genes are targeted by the microRNA let-7, which affects the regulation of other genes. This connection was completely unknown until now. Several other SNPs may affect the structure of chromatin, the chromosome-surrounding proteins. Moreover, the results could have relevance for patients with inherited growth problems, or with problems in bone development, because some of the newly discovered genes have rare mutations, known to be associated with anomalous skeletal growth. Further functional studies are necessary to completely elucidate the biological mechanisms behind this growing list of genes related to height.

As German contribution to the meta-analysis, data from about 5,600 participants of the KORA study were analyzed by the HelmholtzZentrum scientists, Dr. Christian Gieger, Dr. Susana Eyheramendy, PD Dr. Thomas Illig, Dr. Iris M. Heid and Prof. Dr. Dr. H.-Erich Wichmann. In order to genotype 500,000 of the most frequent variants in the human genome, DNA chips were analyzed at the Institute for Human Genetics and the Institute of Epidemiology of the HelmholtzZentrum Mnchen under the direction of Prof. Dr. Thomas Meitinger. The coordinator of the study was Dr. Guillaume Lettre; Prof. Joel Hirschhorn acted as the principal investigator. Both scientists work at the Broad Institute of the MIT and the Harvard University, Cambridge. All investigators are part of the recently formed international consortium to study height and obesity-related traits (GIANT, Genetic Investigation of ANthropometric Traits).

Along with the results of a British study that was published simultaneousl
'/>"/>

Contact: Heinz Joerg Haury
haury@helmholtz-muenchen.de
49-893-187-2460
Helmholtz Zentrum Mnchen - German Research Center for Environmental Health
Source:Eurekalert

Page: 1 2

Related biology news :

1. Computation to unravel how genes are regulated and shed light on how cells become different
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2015)... , March 24, 2015   Crossmatch ... solutions, today announced that its U.are.U ® ... retailer Goorin Bros . to achieve PCI ... solution secures access to the POS terminal, protecting ... risk of data breaches. With ...
(Date:3/23/2015)... YORK , March 23, 2015   HOYOS ... property management company, today announced that the Company will ... for both enterprise and consumers at Connect:ID on March ... HOYOS Labs will highlight the IEEE Biometric ... TM ; and enterprise access control system. BOPS ...
(Date:3/23/2015)... OXFORD, Conn. , Mar. 23, 2015 NXT-ID, Inc. ... authentication company focused on the growing mobile commerce market, announces ... a new advertising campaign on CNBC television starting March 30 ... ads will commence airing in New York ... Executive Officer said: "We are excited about our new ad ...
Breaking Biology News(10 mins):Crossmatch Fingerprint Readers Help Retailer Prevent Data Breaches at Point-of-Sale 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 3NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 2NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 3
... New research in The FASEB Journal suggests that rats ... and increased appetite and muscle mass, as well as the number ... are looking to lean out, add muscle mass, and get ripped, ... ( http://www.fasebj.org ) suggests that you might want to look to ...
... Species, ability to overcome adversity goes beyond Darwin,s survival of ... a new study based on simulations examining species and their ... animal can make it to a final, climate-friendly destination isn,t ... way. It,s the extent to which the creatures can withstand ...
... endangered, but their long lives and broad distribution make ... level to different populations and devise appropriate conservation strategies. ... method to evaluate spatially and biologically distinct groups of ... identify threats and data gaps at different scales. ...
Cached Biology News:Lift weights, eat mustard, build muscles? 2Climate change will show which animals can take the heat 2Climate change will show which animals can take the heat 3
(Date:4/23/2015)... CA (PRWEB) April 23, 2015 Athena ... personal development of executive women in San Diego’s technology ... the 17th Annual Pinnacle Awards at their Gala on ... Hyatt Hotel. Register now at http://athenasd.org/events/ , ... support the Athena San Diego vision of fostering networking, ...
(Date:4/23/2015)... , April 23, 2015  Neurocrine Biosciences, Inc. (Nasdaq: ... report its first quarter 2015 results before the Nasdaq ... then host a live conference call and webcast to discuss ... morning, April 30, 2015 at 8:00 a.m. Eastern Time ... the live conference call by dialing 866-952-1906 (US) or ...
(Date:4/23/2015)... Prospects for Leading Companies in ... Details   We predict the global healthcare ... in 2015 and will grow at a CAGR of 6.3% ... around the world and increasing functional requirements for healthcare packaging ... global healthcare packaging market. A global ageing population, ...
(Date:4/23/2015)... April 23, 2015 /PRNewswire/ - Crystal Research Associates, LLC ... Overview ® (EIO) on Aeterna Zentaris Inc. (NASDAQ: ... available on Crystal Research Associates, website at ... website at www.aezsinc.com . Aeterna Zentaris ... biopharmaceutical company in oncology, endocrinology, and women,s health. With ...
Breaking Biology Technology:Athena Pinnacle Awards to Honor Executives, Corporations and Educators Working to Promote Women Leaders 2Neurocrine Biosciences Announces Conference Call and Webcast to Report First Quarter 2015 Results 2Healthcare Packaging Market Forecast 2015-2025 2Healthcare Packaging Market Forecast 2015-2025 3Healthcare Packaging Market Forecast 2015-2025 4Healthcare Packaging Market Forecast 2015-2025 5Healthcare Packaging Market Forecast 2015-2025 6Healthcare Packaging Market Forecast 2015-2025 7Healthcare Packaging Market Forecast 2015-2025 8Healthcare Packaging Market Forecast 2015-2025 9Healthcare Packaging Market Forecast 2015-2025 10Crystal Research Associates, LLC Issues Executive Informational Overview (EIO) on Aeterna Zentaris Inc. 2Crystal Research Associates, LLC Issues Executive Informational Overview (EIO) on Aeterna Zentaris Inc. 3
... Sept. 19 NPS,Pharmaceuticals, Inc. (Nasdaq: NPSP ... Administration,s Office of Orphan Products Development has granted,orphan ... for,injection) for the treatment of hypoparathyroidism, a rare ... FDA-approved therapy. Hypoparathyroidism afflicts approximately 65,000 people ...
... NeurogesX, Inc.,(Nasdaq: NGSX ), a biopharmaceutical company ... it is scheduled to present,at the 2007 UBS Global ... President and Chief Executive Officer, and Jeffery,Tobias, Chief Medical ... September 25, 2007 Time: 9:00 a.m. ...
... Sept. 19 The Pittsburgh Life Sciences,Greenhouse ... life,sciences industry on a fast track for ... in Coventina Healthcare Enterprises, Inc., a medical,device ... Frequency),and multi-modal treatment systems for research, rehabilitation, ...
Cached Biology Technology:PREOS(R) Granted U.S. Orphan Drug Status for Treatment of Hypoparathyroidism 2PREOS(R) Granted U.S. Orphan Drug Status for Treatment of Hypoparathyroidism 3NeurogesX to Present at UBS 2007 Global Life Sciences Conference 2NeurogesX to Present at UBS 2007 Global Life Sciences Conference 3The PLSG Invests $150,000 in Coventina Healthcare Enterprises, Inc., Its Eighth Company Relocation to Pittsburgh 2The PLSG Invests $150,000 in Coventina Healthcare Enterprises, Inc., Its Eighth Company Relocation to Pittsburgh 3
Agar, 500 g. Noble Agar.Moisture: < 10%, ash: < 1.6%, EEO (-mr): < 0.450 (pH 8.4). Category: Nucleotides & Enzymes & Biochemicals, Ultrapure Biochemicals ....
Ms anti-Cyclophilin D...
... Intended to qualitatively detect ... formalin-fixed, paraffin-embedded (FFPE) tissue ... and cell preparations, using ... (CISH). Fluorescent In Situ ...
Mouse GM CSF Construction Kit provides antigen affinity purified polyclonal capture and tracer antibodies, and antigen standard for development of approximately ten microplate assays....
Biology Products: