Navigation Links
How body size is regulated
Date:5/9/2008

This meta-analysis, published in the latest issue of Nature Genetics, is based on data from more than 26,000 study participants. It verifies two already known genes, but also discovered ten new genes. Altogether they explain a difference in body size of about 3.5 centimeters.

The analysis produced some biologically insightful findings. Several of the identified genes are targeted by the microRNA let-7, which affects the regulation of other genes. This connection was completely unknown until now. Several other SNPs may affect the structure of chromatin, the chromosome-surrounding proteins. Moreover, the results could have relevance for patients with inherited growth problems, or with problems in bone development, because some of the newly discovered genes have rare mutations, known to be associated with anomalous skeletal growth. Further functional studies are necessary to completely elucidate the biological mechanisms behind this growing list of genes related to height.

As German contribution to the meta-analysis, data from about 5,600 participants of the KORA study were analyzed by the HelmholtzZentrum scientists, Dr. Christian Gieger, Dr. Susana Eyheramendy, PD Dr. Thomas Illig, Dr. Iris M. Heid and Prof. Dr. Dr. H.-Erich Wichmann. In order to genotype 500,000 of the most frequent variants in the human genome, DNA chips were analyzed at the Institute for Human Genetics and the Institute of Epidemiology of the HelmholtzZentrum Mnchen under the direction of Prof. Dr. Thomas Meitinger. The coordinator of the study was Dr. Guillaume Lettre; Prof. Joel Hirschhorn acted as the principal investigator. Both scientists work at the Broad Institute of the MIT and the Harvard University, Cambridge. All investigators are part of the recently formed international consortium to study height and obesity-related traits (GIANT, Genetic Investigation of ANthropometric Traits).

Along with the results of a British study that was published simultaneousl
'/>"/>

Contact: Heinz Joerg Haury
haury@helmholtz-muenchen.de
49-893-187-2460
Helmholtz Zentrum Mnchen - German Research Center for Environmental Health
Source:Eurekalert

Page: 1 2

Related biology news :

1. Computation to unravel how genes are regulated and shed light on how cells become different
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/27/2014)... might have survived the asteroid strike that wiped them ... later in history, scientists say. , A fresh study ... helped palaeontologists to build a new narrative of the ... They found that in the few million years before ... was experiencing environmental upheaval. This included extensive volcanic activity, ...
(Date:7/27/2014)... climate change to cut food supplies. But these studies ... increasing temperature and air pollution specifically ozone pollution, ... study involving researchers at MIT shows that these interactions ... take both warming and air pollution into account in ... at global production of four leading food crops ...
(Date:7/25/2014)... In the first broad-scale estimate of air pollution removal ... calculated that trees are saving more than 850 human ... respiratory symptoms. , While trees, pollution removal equated to ... percent, the impacts of that improvement are substantial. Researchers ... pollution at nearly $7 billion every year in a ...
Breaking Biology News(10 mins):Dinosaurs fell victim to perfect storm of events, study shows 2Study: Climate change and air pollution will combine to curb food supplies 2Study: Climate change and air pollution will combine to curb food supplies 3First national study finds trees saving lives, reducing respiratory problems 2
... up efforts to cut waste, reduce energy use and ... the number of planet-friendly standards and regulations also is ... of options for "going green." National Institute of Standards ... help organizations of all types sort through the welter ...
... Exotic bacteria that do not rely on oxygen may have ... early atmosphere, according to a theory that UChicago researcher Albert ... volcanic crater in Siberia. He has found that bacteria ... a surprising twist that scientists must take into account as ...
... American Chemical Society (ACS) today released a new episode ... podcast series showcasing a discovery that could mean greener ... used to make everything from paint to diapers. ... new way to make acrylic acid, a key industrial ...
Cached Biology News:NIST prototypes framework for evaluating sustainability standards 2Cold case: Siberian hot springs reveal ancient ecology 2Cold case: Siberian hot springs reveal ancient ecology 3
(Date:7/25/2014)... CA (PRWEB) July 25, 2014 WABC Radio ... Your Pet with Lorry Young will be hosting California-based ... talk about stem cell therapy in pets. Dr. Harman ... benefits of stem cell therapy for pets suffering from osteoarthritis ... the Regenerative Veterinary Medicine industry forward. , Young has invited ...
(Date:7/25/2014)... IN (PRWEB) July 25, 2014 At ... (FAA) has granted a 60-day extension for the public ... the Special Rule for Model Aircraft established by Congress ... of 2012. The 60-day extension establishes the new deadline ... United States Department of Transportation/FAA notice published in the ...
(Date:7/24/2014)... 2014  Now available is a stem cell therapy ... Therapies , located in Guadalajara, Mexico ... a new health option: stem cell therapies for ... patients suffer from joint and muscle injuries due to ... torn rotator cuff, tennis elbow, and knee injuries. Throughout ...
(Date:7/24/2014)... scientists are making progress in devising suitable means ... relies on quantum dotsa kind of artificial atom, ... new study demonstrates that changing the coupling of ... impulses can help better control them. This has ... quantum information units, which would produce faster quantum ...
Breaking Biology Technology:Robert J. Harman, DVM, Founder and CEO of Vet-Stem, Inc. to Join New York Radio Host Lorry Young in Upcoming Episode of A “Paws” For Your Pet 2Robert J. Harman, DVM, Founder and CEO of Vet-Stem, Inc. to Join New York Radio Host Lorry Young in Upcoming Episode of A “Paws” For Your Pet 3FAA Grants Comment Extension at the Request of AMA 2Stem Cells In Sports Injuries, Joints And Muscular Pain 2Stem Cells In Sports Injuries, Joints And Muscular Pain 3
... , , SAN DIEGO, July ... finalization of the protocol for the Company,s Phase II trial of ANA598 ... Allowance of the protocol has been received from the United States Food ... the next several weeks. , , In the Phase ...
... ... efficiency, renewable energy and reforestation projects , ... Falmouth, ME (PRWEB) July 30, 2009 -- IntertechPira has teamed ... associated with the 2009 Biopolymers Symposium and is offsetting those emissions to make the ...
... , , RALEIGH, N.C. , ... for the management and analysis of genetic data, today announced that ... Hospital will utilize SmartGene,s advanced technology and integrated Web-based services to ... by sequence analysis. , , Some bacteria and ...
Cached Biology Technology:Anadys Pharmaceuticals Receives FDA Clearance of Phase II Protocol to Study ANA598 in Combination With Interferon-Alpha and Ribavirin in HCV Patients 2Anadys Pharmaceuticals Receives FDA Clearance of Phase II Protocol to Study ANA598 in Combination With Interferon-Alpha and Ribavirin in HCV Patients 3Anadys Pharmaceuticals Receives FDA Clearance of Phase II Protocol to Study ANA598 in Combination With Interferon-Alpha and Ribavirin in HCV Patients 4Anadys Pharmaceuticals Receives FDA Clearance of Phase II Protocol to Study ANA598 in Combination With Interferon-Alpha and Ribavirin in HCV Patients 5Biopolymers Symposium 2009 Teams with Carbonfund.org to Create a Zero-Carbon Event 2SmartGene's Services for Faster, More Precise Identification of Bacteria and Fungi to be Used by The Johns Hopkins Hospital 2
... HVJ (hemagglutinating virus of Japan, also ... a tool for transfection of molecules by ... are for siRNA (RNAi), Protein, Oligo, cDNA, ... and in vivo. GenomONE-Neo EX has a ...
... Genome ChIP-on-chip Microarray is specifically designed ... cerevisiae) DNA binding proteins by pairing ... microarrays. This set delivers robust hybridization ... true binding events and fewer false ...
... Faster speeds, highest precision, more user-friendliness ... concept: this is the definition of the ... years nucleic acid research has been developing ... required of PCR Systems. To keep ...
... to help promote genomics-based research with S. aureus, ... that contains PCR primers to amplify all open ... addition, primer pairs are included to amplify ORFs ... N315 strains of S. aureus. The ORFmer set ...
Biology Products: