Navigation Links
How bacteria integrate autotransporters into their outer membrane
Date:9/23/2013

The bacterial outer envelope is densely packed with proteins that form small pores and facilitate the passage of nutrients, toxins and signaling molecules. Professors Timm Maier and Sebastian Hiller from the Biozentrum of the University of Basel now demonstrate how these transporter proteins are integrated into the outer membrane. Using x-ray structural analysis they reveal the structure-function relationship of the protein TamA, which plays an important role in the assembly of transport proteins in the bacterial outer membrane. Their findings have been published recently in the renowned scientific journal Nature Structural and Molecular Biology.

Shuttling proteins from inside the cell to the outside environment is a complex task for Gram-negative bacteria, which are not only surrounded by an inner membrane, but also by an outer membrane barrier for protection against adverse environmental conditions. The bacteria however, can overcome this additional barrier by inserting special transport proteins into the protective outer membrane. In a joint project, Maier and Hiller, both Professors of Structural Biology at the Biozentrum of the University of Basel, provide mechanistic insights into this key process.

The structure of the assembly protein TamA explains its function

An important option for channeling protein domains across the outer membrane are so-called autotransporters. These membrane proteins form a barrel-like structure with a central pore, but they cannot autonomously transport their "passenger domain" across the outer membrane. Specific assembly proteins are required for the folding and integration of autotransporters into the outer membrane. Employing x-ray crystallography, the authors of the study decoded the atomic structure of the autotransporter assembly protein TamA of the intestinal bacterium Escherichia Coli.

"The protein TamA", explains Fabian Gruss, first author and recipient of a Werner-Siemen
'/>"/>

Contact: Olivia Poisson
olivia.poisson@unibas.ch
University of Basel
Source:Eurekalert

Page: 1 2

Related biology news :

1. Leading evolutionary scientist to discuss how genome of bacteria has evolved
2. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
3. Team discovers how bacteria resist a Trojan horse antibiotic
4. From scourge to saint: E. coli bacteria becomes a factory - to make cheaper, faster pharmaceuticals
5. Bacterial shock to recapture essential phosphate
6. Disarming disease-causing bacteria
7. Study shows unified process of evolution in bacteria and sexual eukaryotes
8. Invisible helpers: How probiotic bacteria protect against inflammatory bowel diseases
9. Researchers develop rapid test strips for bacterial contamination in swimming water
10. Bacteria discovery could lead to antibiotics alternatives
11. Agricultural bacteria: Blowing in the wind
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... The 10 th International Conference on Genomics ... 22-25, 2015, in Shenzhen , ... 10 th anniversary this year. Since its inauguration in ... annual meetings in the ,omics, fields, and is one of ... ICG-10 focuses on recent breakthroughs and advances in ,omics, ...
(Date:7/27/2015)... SAN JOSE, Calif. , July 27, 2015 ... leading developer of human interface solutions, today announced ... ClearPad ® touchscreen solution for its stylish ... controller for its proven reliability, low power and ... with a wet finger. Huawei designers also required ...
(Date:7/23/2015)... July 23, 2015 Aware, Inc. (NASDAQ: AWRE ... reported financial results for its second quarter ended June 30, ... 2015 was $4.5 million, a decrease of 33% compared to ... in the second quarter of 2015 was $0.3 million, or ... $0.04 per diluted share, in the same period a year ...
Breaking Biology News(10 mins):The 10th International Conference on Genomics (ICG-10) to Open in October 2Synaptics Touchscreen Solution Powers New Huawei Watch 2Synaptics Touchscreen Solution Powers New Huawei Watch 3Aware, Inc. Reports Second Quarter 2015 Financial Results 2Aware, Inc. Reports Second Quarter 2015 Financial Results 3Aware, Inc. Reports Second Quarter 2015 Financial Results 4Aware, Inc. Reports Second Quarter 2015 Financial Results 5Aware, Inc. Reports Second Quarter 2015 Financial Results 6
... -- From a bike path in Montana to a ... fanned out last June to capture high-resolution images for ... even broader participation in their efforts to document global ... for the solstice week of Dec. 19-26., The ...
... from the University of Sheffield comparing rats and mice ... whiskers were an important milestone in the evolution of ... and automatic tracking, the research team, which was led ... Psychology, have shed light on how rodents such as ...
... EAST LANSING, Mich. -- A diet high in fiber ... is tied to a lower risk of heart disease ... Michigan State University. A study led by Joseph Carlson ... reduce metabolic syndrome a collection of risk factors including ...
Cached Biology News:GigaBlitz event seeks citizen scientists to capture images of nearby biodiversity 2GigaBlitz event seeks citizen scientists to capture images of nearby biodiversity 3Whiskers marked milestone in evolution of mammals from reptiles 2More fiber, but not necessarily less fat, good for teen diets 2
(Date:8/3/2015)... ... , ... Nine field days to promote practices that improve soil health will ... Health Partnership , the field days will demonstrate how changing certain practices, such as ... income. , Brent Bible has practiced no-till farming and planted cover crops on his ...
(Date:8/3/2015)... /PRNewswire/ - RepliCel Life Sciences Inc. (TSX.V: RP) (OTCQB: REPCF), ... of autologous cell therapies, announced today that RepliCel,s CEO, ... held in Minneapolis, Minnesota on August ... will highlight RepliCel,s 18-month milestones including CE Mark for its ... , clinical data from both RCT-01 (tendon) and RCS-01 (skin) ...
(Date:7/31/2015)... ... July 31, 2015 , ... ... detection and quantification of partially hydrolyzed gluten in foods, has been accepted by ... the method “Partially Hydrolyzed Gluten in Fermented Cereal-Based Products by R5 Competitive ELISA,” ...
(Date:7/30/2015)... ... July 30, 2015 , ... The 2015 Market Research Report on the ... of the global Propanol market with a focus on the Chinese situation. Major companies ... Chemicals, Oxea, ISU Chemical, Sanofi, Royal Dutch Shell, LG Chem and Zhejiang Xinhua Chemical. ...
Breaking Biology Technology:Soil Health Field Days Kick Off Throughout Midwest 2Soil Health Field Days Kick Off Throughout Midwest 3RepliCel Presenting at InvestMNT Investor Conference in Minneapolis 2RIDASCREEN® Competitve Gliadin Receives AOAC Official First Action Status 2Global Propanol Market Technical Data and Manufacturing Analysis 2020 2Global Propanol Market Technical Data and Manufacturing Analysis 2020 3
... Easily Locating Adhererent , Cells , , ... , , ... cells that have been used for microinjection. These sterile coverslips , ... with the original microgrid patterns it is easy ...
... , , , , , ... Kiel, Germany , Susanne Wagner, Eppendorf AG, , ... Introduction , , , , , ... Ongoing developments of tubes, pipettes, and pipette tips enable drastic ...
... reporting system for ... Mary Buchanan Chao-Feng Zheng ,Stratagene , Stratagenes ... is designed for studying the activation,of the nuclear factor ... play an essential role in inducible gene expression,during immune ...
Cached Biology Technology:A membrane-lid tube for bacteria cultivation and freeze-drying 2A membrane-lid tube for bacteria cultivation and freeze-drying 3A membrane-lid tube for bacteria cultivation and freeze-drying 4A membrane-lid tube for bacteria cultivation and freeze-drying 5A membrane-lid tube for bacteria cultivation and freeze-drying 6A membrane-lid tube for bacteria cultivation and freeze-drying 7Cis-Reporting System Monitors Intracellular Calcium Mobilization 2Cis-Reporting System Monitors Intracellular Calcium Mobilization 3Cis-Reporting System Monitors Intracellular Calcium Mobilization 4Cis-Reporting System Monitors Intracellular Calcium Mobilization 5
Prepared from plasminogen by activation with immobilized human uPA...
Human FADD Affinity Purified Polyclonal Ab...
(3-[125I]iodotyrosyl26)Galanin (porcine), 925 kBq, 25 uCi. Category: IODINE LIGANDS....
... The high-performance triple quadrupole 1200L sets ... today's cost-conscious environment - incorporating the ... for all liquid chromatography analytical needs. ... interface and the Transmission Quadrupole Analyzer ...
Biology Products: