Navigation Links
How bacteria change movement direction in response to oxygen: Molecular interactions unravelled
Date:6/25/2012

How single cell organisms like bacteria manage to react to their environment is not yet completely understood. Together with colleagues from Japan, Dr. Samir El-Mashtoly from the RUB Department of Biophysics, led by Prof. Dr. Klaus Gerwert, has gained new insights into the molecular interactions during aerotaxis of Bacillus subtilis, i.e., the dependence of the movement direction on the oxygen concentration in the environment. The research team investigated the conformational changes within the protein HemAT. Via a signal transduction chain, this protein sends a command to the flagellar motor which controls the movement direction. They report in the Journal of Biological Chemistry.

Signal transduction chain

The signal transduction chain starts with binding of oxygen to HemAT's heme domain, which is also known from haemoglobin in the red blood cells and is called the sensor domain of HemAT. Oxygen binding leads to a conformational change in the sensor domain. This in turn provokes several further conformational changes within HemAT that finally affect the signalling domain of the protein. The signalling domain then transmits the information about a rise in oxygen concentration to other proteins within the cell. These proteins forward the message to the motor of the flagellum. The research team investigated how the information travels from the sensor domain of HemAT to its signalling domain.

Protein helices forward the information

For that purpose, Dr. El-Mashtoly used the time-resolved ultraviolet resonance Raman spectroscopic facilities in the Picobiology Institute in Japan. This method provides, for instance, structural information about the conformation of the protein and hydrogen bonding interactions on a nanosecond to microsecond time scale. The results suggest that the conformational change in the sensor domain, i.e., the heme structure, induces the displacement of two protein helices within
'/>"/>

Contact: Dr. Samir El-Mashtoly
samir.elmashtoly@bph.rub.de
49-234-322-9833
Ruhr-University Bochum
Source:Eurekalert

Page: 1 2

Related biology news :

1. Discovery increases understanding how bacteria spread: U of A study
2. Research identifies specific bacteria linked to indoor water-damage and mold
3. Brothers in arms: Commensal bacteria help fight viruses
4. Intestinal bacteria produce neurotransmitter, could play role in inflammation
5. Normal bacterial makeup has huge implications for health, says CU professor
6. Consortium of scientists maps the human bodys bacterial ecosystem
7. More than 1 way to be healthy: Map of bacterial makeup of humans reveals microbial rare biosphere
8. IU role in Human Microbiome Project exposes battle history between bacteria, viruses in human body
9. The activity of a bacterial effector protein seen in molecular detail
10. Light-induced delivery of nitric oxide eradicates drug-resistant bacteria
11. Arctic bacteria help in the search to find life on moon Europa
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)...  BellBrook Labs, a leader in high throughput screening ... a TR-FRET (time resolved Forster resonance energy transfer) ... high throughput screening assay for glycosyltransferases and other ... sensitive detection of hundreds of human and microbial ...
(Date:1/22/2015)... POINT ROBERTS, Washington , January 20, 2015 ... including technology and tech stocks, releases video from the CES ... and security consultant Apollo Robbins . Apollo ... the Wocket™ biometric smart wallet, a product of NXT-ID, Inc. ...
(Date:1/22/2015)... , Jan. 22, 2015 Research and Markets ... of the "Global Wearable Technologies Market and ... Overview, Trends and Forecast 2014-2020" report to ... are smart devices that can be worn on ...
Breaking Biology News(10 mins):BellBrook Labs Launches a High Throughput Screening Assay for Glycosyltransferases with TR-FRET Readout 2Apollo Robbins Talks about the Illusion of Personal Safety and How Easily Your Wallet is Stolen; If a Wocket Wallet is Stolen the Thief Can't do Anything With it! 2Apollo Robbins Talks about the Illusion of Personal Safety and How Easily Your Wallet is Stolen; If a Wocket Wallet is Stolen the Thief Can't do Anything With it! 3Global Wearable Technologies Market and Applications, Opportunities, Industry Analysis, Segmentation, Size, Growth, Share, Overview, Trends and Forecast 2014-2020 2
... School of Medicine have found evidence that a hormone ... functions of spatial learning and memory development, and further ... stomach. , Published in the February 19 online issue ... institutes, the study showed that the hormone ghrelin, produced ...
... cartilage offers the first hope of replacing the ... The technique, developed at Rice University's Musculoskeletal Bioengineering ... the journal Tissue Engineering. , "This has significant ... for the first time, about the potential treatment ...
... led by a University of Minnesota researcher has found a ... kinds and sizes and that may also offer a key ... be known precisely in order to construct valid models of ... occur in both plants and animals through the process of ...
Cached Biology News:Learning and memory stimulated by gut hormone 2Rice bioengineers pioneer techniques for knee repair 2Of mice, men, trees and the global carbon cycle 2Of mice, men, trees and the global carbon cycle 3
(Date:1/23/2015)... Portal Solutions , a technology consulting firm that ... 365 and SharePoint platforms , today announces its inclusion in ... of the region’s fastest-growing mid-sized companies based on a combined ... be recognized a second year in a row by SmartCEO ...
(Date:1/22/2015)... 2015  Transwestern | RBJ today announces the firm brokered a ... Shire a leading biopharmaceutical company, at Two Ledgemont Center in ... Robert Richards , president, and Brian Cohen , senior ... five-floor building at 95 Hayden Ave. Photo - ...
(Date:1/22/2015)... Pipette.com has added the Eppendorf ... portfolio of Eppendorf products. , The Eppendorf Centrifuge 5424/5424 ... 5424/5424 R and receive the following:, , ... or Eppendorf Reference 2 ,     3 Free ...
(Date:1/22/2015)... NJ (PRWEB) January 22, 2015 ... technologies such as the Bioruptor® and complete solutions ... system for chromatin immunoprecipitation, alleviating the need for ... and controls needed for ChIP of histones or ...
Breaking Biology Technology:Washington SmartCEO Announces Portal Solutions as 2015 Future 50 Award Winner Second Year in a Row 2Washington SmartCEO Announces Portal Solutions as 2015 Future 50 Award Winner Second Year in a Row 3Transwestern?RBJ Advises Shire in 202,000 SF Lease, Creating Boston's Largest Suburban Biotech Campus 2Eppendorf Announces Promotional Bundle Which Includes: Eppendorf Centrifuge 5424, 3-Pack of Pipettes, and Tips - Available Now at Pipette.com 2Diagenode Launches Unique Semi-Automated Solution for Chromatin Immunoprecipitation 2
... project between the University of Wisconsin-Madison and ... has shown that thousands of sleeping computers can unravel ... , a program first developed at Technion for identifying ... affected families, has since grown to operate on 200 ...
... Information Exchange has been awarded an eHealth initiative ... calendar year 2006. , ,The funds will allow ... to develop its governance structure and administrative staff. To ... through sharp increases in emergency room traffic, the contract ...
... - Metavante Corp ., the banking and ... ., is in the final stages of acquiring ... payment processing software. , ,VICOR is being pursued, in ... solutions to its client financial institutions so they can ...
Cached Biology Technology:UW links with Israeli school to locate genes 2UW links with Israeli school to locate genes 3WHIE receives state eHealth Initiative contract 2
...
Auto/Zyme Reagent...
HistoScan HRP Kit Universal Goat Kit...
Interact with both DNA and RNA; fluorescence green (Em=525 nm) bound to DNA; and fluorescence red (Em=~650 nm) bound to RNA....
Biology Products: