Clustering also allows the genes to be controlled in a coordinated manner, and comparing the gene clusters gave the scientists hints of how this might happen. Both gene clusters show signs that they are regulated by the way the DNA molecule folds or unfolds into chromatin, whilst neighbouring genes outside the clusters don't. Furthermore, it appears that this level of coordinated gene expression has been acquired by the cluster after its assembly.
These insights into the way these gene clusters have evolved and function will be particularly valuable for efforts to fully exploit the potential of plants to produce valuable products. The ever-growing amount of data being generated by genome sequencing projects can be explored further, to try to discover similar gene clusters. For genes that have already been discovered, this information on clustering genes will help in efforts to use synthetic biology to optimise the production of new drugs, herbicides and other plant products.
|Contact: Andrew Chapple|
Norwich BioScience Institutes