Navigation Links
How a Silly Putty ingredient could advance stem cell therapies
Date:4/13/2014

ANN ARBORThe sponginess of the environment where human embryonic stem cells are growing affects the type of specialized cells they eventually become, a University of Michigan study shows.

The researchers coaxed human embryonic stem cells to turn into working spinal cord cells more efficiently by growing the cells on a soft, utrafine carpet made of a key ingredient in Silly Putty. Their study is published online at Nature Materials on April 13.

This research is the first to directly link physical, as opposed to chemical, signals to human embryonic stem cell differentiation. Differentiation is the process of the source cells morphing into the body's more than 200 cell types that become muscle, bone, nerves and organs, for example.

Jianping Fu, U-M assistant professor of mechanical engineering, says the findings raise the possibility of a more efficient way to guide stem cells to differentiate and potentially provide therapies for diseases such as amyotrophic lateral sclerosis (Lou Gehrig's disease), Huntington's or Alzheimer's.

In the specially engineered growth systemthe 'carpets' Fu and his colleagues designedmicroscopic posts of the Silly Putty component polydimethylsiloxane serve as the threads. By varying the post height, the researchers can adjust the stiffness of the surface they grow cells on. Shorter posts are more rigidlike an industrial carpet. Taller ones are softermore plush.

The team found that stem cells they grew on the tall, softer micropost carpets turned into nerve cells much faster and more often than those they grew on the stiffer surfaces. After 23 days, the colonies of spinal cord cellsmotor neurons that control how muscles movethat grew on the softer micropost carpets were four times more pure and 10 times larger than those growing on either traditional plates or rigid carpets.

"This is extremely exciting," Fu said. "To realize promising clinical applications of human embry
'/>"/>

Contact: Nicole Casal Moore
ncmoore@umich.edu
734-647-7087
University of Michigan
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Hot sauce ingredient reduces beer belly fat as a weight-loss surgery alternative
2. Study sheds new light on importance of human breast milk ingredient
3. New oil spill dispersant made from ingredients in peanut butter, chocolate, ice cream
4. A sip of resveratrol and a full p53: Ingredients for a successful cell death
5. New and revised standards for omega-3s, natural sweeteners and other food ingredients proposed
6. Discoveries suggest icy cosmic start for amino acids and DNA ingredients
7. New DNA test identifies ingredients in foods
8. Recipe for large numbers of stem cells requires only one ingredient, says NIH/Pitt team
9. New technologies and ingredients provide better options for gluten-free eating
10. A greener, more sustainable source of ingredients for widely used plastics
11. Ingredient in turmeric spice when combined with anti-nausea drug kills cancer cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... treatment has been shown to relieve patients, pain. ... transmission between the peripheral and central nervous systems, ... Radiation Medicine, Chinese Academy of Medical Sciences, China ... dorsal root ganglia (DRG) to provide relief for ... 14.8, 29.6 MBq) were implanted separately into the ...
(Date:7/30/2014)... of cells types. Researchers would like to understand how to ... that make up the organs and other structures of living ... of sugars that dangle from proteins on surfaces of cells. ... Diego, has created synthetic molecules that can stand in for ... direct the process, they report in the Journal of ...
(Date:7/30/2014)... Calif. , July 30, 2014 ... with the United States Air Force Research Laboratory ... by Binghamton University to ... performance monitoring (HPM). The $425,000 project, with contributions ... packaging firm i3 Electronics, Inc. ( Endicott, ...
Breaking Biology News(10 mins):Nano-Bio Manufacturing Consortium Awards Funding to Binghamton University for Development of Electronics and Biometric Sensor Platforms 2Nano-Bio Manufacturing Consortium Awards Funding to Binghamton University for Development of Electronics and Biometric Sensor Platforms 3
... Researchers studying a type of cell found in the trillions ... how it responds to brain injury and disease such as ... trigger the processes that underlie how astrocyte cells respond to ... humans, are a type of glial cell that comprise one ...
... 25, 2013 , , , WHEN:               ... 1, 2013 , , , , LOCATION:       ... , , , SPEAKER:        , , , ... Augmented reality (AR) is here to ...
... of regular aerial surveys and genetics data collected by a ... the central Gulf of Maine as a mating ground for ... online in the journal Endangered Species Research . ... one of the most endangered marine mammal species in the ...
Cached Biology News:Key target responsible for triggering detrimental effects in brain trauma identified 2The (Augmented) Reality of the Situation: Emerging Trends and Issues 2The (Augmented) Reality of the Situation: Emerging Trends and Issues 3Are North Atlantic right whales mating in the Gulf of Maine? 2Are North Atlantic right whales mating in the Gulf of Maine? 3
(Date:7/31/2014)... Miami, Fla. (PRWEB) July 31, 2014 The ... for distribution of its monthly news magazine, Kidney Cancer News. ... have a presence on a website maintained by an international ... noted an immediate increase in viewers.” , This month’s program ... of kidney tumors analyzed in a recent study. Kidney ...
(Date:7/31/2014)... Sales Horizons, a leader in sales training, today ... – Mastering the Complex Sale – to ... proven sales training programs used by thousands of salespeople ... sales training course is available to every salesperson as ... customers, like technical support, engineers, clinical support, and IT ...
(Date:7/30/2014)... PARIS , July 30, 2014  Regeneron Pharmaceuticals, ... SNY) today announced that the Companies intend to use ... disease priority review voucher in connection with the Biologics ... voucher entitles the holder to designate a BLA for ... from the filing date instead of the standard 10-month ...
(Date:7/30/2014)... 30, 2014  Decision Resources Group finds that ... in the United States ... penetration will be the level of savings achievable ... expected lower cost to patients. Payers plan to ... their pricing expectations in order to encourage physician ...
Breaking Biology Technology:Sales Horizons Offers Mastering the Complex Sale - a Comprehensive, Online Sales Skills Training Course 2Sales Horizons Offers Mastering the Complex Sale - a Comprehensive, Online Sales Skills Training Course 3Regeneron and Sanofi Announce Plan to Use Priority Review Voucher For Alirocumab U.S. FDA Submission 2Regeneron and Sanofi Announce Plan to Use Priority Review Voucher For Alirocumab U.S. FDA Submission 3Regeneron and Sanofi Announce Plan to Use Priority Review Voucher For Alirocumab U.S. FDA Submission 4Regeneron and Sanofi Announce Plan to Use Priority Review Voucher For Alirocumab U.S. FDA Submission 5Regeneron and Sanofi Announce Plan to Use Priority Review Voucher For Alirocumab U.S. FDA Submission 6Surveyed U.S. Payers Expect Cost Savings to MCOs and Patients to be the Strongest Drivers of Biosimilar Uptake 2Surveyed U.S. Payers Expect Cost Savings to MCOs and Patients to be the Strongest Drivers of Biosimilar Uptake 3
... PARK, N.C. and MIAMI, Oct. 13 The Alpha-1 ... grants to study how genetic variations in the alpha-1 ... in people with AAT deficiency. The inherited condition causes ... whether AAT infusion therapy -- known as augmentation therapy ...
... , CHICAGO, Oct. 13 Advanced Life Sciences ... company engaged in the discovery, development and commercialization ... infection, cancer and respiratory diseases, today announced that ... held October 28-29th in San Francisco. , (Logo: ...
... LONDON, October 13 Systagenix Wound Management ... Board, consisting of,a group of multi-disciplinary and highly respected ... which will be led by,Systagenix,s newly appointed Medical Director, ... major specialist organisations and thought leaders in the,wound care ...
Cached Biology Technology:The Alpha-1 Foundation Awards Two Research Grants with Support from Talecris Biotherapeutics, Inc. 2The Alpha-1 Foundation Awards Two Research Grants with Support from Talecris Biotherapeutics, Inc. 3The Alpha-1 Foundation Awards Two Research Grants with Support from Talecris Biotherapeutics, Inc. 4Advanced Life Sciences to Present at 8th Annual BIO Investor Forum 2Systagenix Announces Formation of New Global Medical Advisory Board to Support Future Clinical Advances in Wound Care 2Systagenix Announces Formation of New Global Medical Advisory Board to Support Future Clinical Advances in Wound Care 3Systagenix Announces Formation of New Global Medical Advisory Board to Support Future Clinical Advances in Wound Care 4Systagenix Announces Formation of New Global Medical Advisory Board to Support Future Clinical Advances in Wound Care 5Systagenix Announces Formation of New Global Medical Advisory Board to Support Future Clinical Advances in Wound Care 6
... Oxidized LDL (Competitive) EIA Principle: ... the monoclonal antibody 4E6. Oxidized LDL in the ... LDL bound to the microtiter well for the ... a washing st Sample Size: 25 ...
... diluent that is designed for use with HRP ... with a mouse monoclonal coating antibody. ... proteins to prevent non-specific binding between the coating ... This buffer may be used to stabilize newly ...
OmniSlide Heated Wash Module. 2 independent chambers with precise temperature control from ambient of 5C to 70C. Each chamber holds 1 slide rack (20 slides). Includes 2 x Wash Sleeves, 1 x Slide R...
Request Info...
Biology Products: