Navigation Links
How Toxoplasma gondii gets noticed
Date:1/19/2009

Researchers provide insight into how Toxoplasma gondii, a common parasite of people and other animals, triggers an immune response in its host. The report will appear online on January 19th in The Journal of Experimental Medicine.

A strong immune response spares T. gondii-infected hosts from deadly infectionan event that may also benefit the parasite, which relies on survival of the host to ensure its own transmission. But how the infected host elicits an immune response isn't completely understood. Like many other parasites, T. gondii resides within specialized vesicles inside infected host cells, but the process by which peptides from the trapped bugs are processed by infected cells and presented to killer T cells is mysterious.

Here, Romina Goldszmid and her colleagues at the National Institutes of Health in Bethesda use T. gondii infections in mice to study how portions of the parasitic proteins escape the vesicle in a process known as cross-presentation. They find that the parasite gets noticed by the immune system when the membrane of the bug-containing vesicle fuses to the endoplasmic reticuluman organelle normally involved in presenting pathogens to T cellsallowing a swap of parasitic peptides.


'/>"/>

Contact: Amy Maxmen
amaxmen@rockefeller.edu
Rockefeller University Press
Source:Eurekalert

Page: 1

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/30/2017)... ANGELES , March 30, 2017  On April ... Hack the Genome hackathon at Microsoft,s ... exciting two-day competition will focus on developing health and ... Hack the Genome is the ... been tremendous. The world,s largest companies in the genomics, ...
(Date:3/27/2017)... ROCKVILLE CENTRE, N.Y. , March 27, 2017 ... by Healthcare Information and Management Systems Society (HIMSS) ... Analytics Outpatient EMR Adoption Model sm . In ... top 12% of U.S. hospitals using an electronic ... recognized CHS for its high level of EMR ...
(Date:3/22/2017)... VILNIUS, Lithuania , March 21, 2017 /PRNewswire/ ... identification and object recognition technologies, today announced the ... development kit (SDK), which provides improved facial recognition ... safety cameras on a single computer. The new ... algorithms to improve accuracy, and it utilizes a ...
Breaking Biology News(10 mins):
(Date:6/20/2017)... ... ... Biologist Dawn Maslar MS has found a biomarker that she claims verifies ... The Neuroscience of Meeting, Dating, Losing Your Mind, and Finding True Love, Maslar found ... step, in my estimation, was to scientifically track the evidence of commitment in men,” ...
(Date:6/20/2017)... ... June 20, 2017 , ... ... of antibody therapeutics from millions-diverse immune repertoires, announces launch of its new ... California. Dave Johnson, PhD, CEO of GigaGen, will present on Surge at the ...
(Date:6/16/2017)... ... June 16, 2017 , ... Cognition Corporation , ... two more sessions of its “From the Helm” Webinar Series. , The ... online templates for design control exercises. Led by David Cronin, Cognition’s CEO, the ...
(Date:6/15/2017)... Philadelphia, PA (PRWEB) , ... June 15, 2017 ... ... Center’s Esther Klein Gallery (EKG) follows an artist’s journey through creative experimentation and ... 22, 2017 and runs through July 22nd. An opening reception will be held ...
Breaking Biology Technology: