Navigation Links
How HIV cripples immune cells
Date:9/16/2009

ly on their mobility.

Short-circuiting of two different signal paths in the cell by Nef

The researchers examined the movement of cells in living zebra fish embryos and were able to show that cell mobility is inhibited by the HIV Nef protein. As they continued their experiments on cell cultures, they were able to explain the underlying mechanism: Nef causes an enzyme that normally has nothing to do with cell mobility to deactivate a regulator for actin regeneration. Nef therefore causes a short-circuit of two cellular mechanisms, thus inhibiting the reorganization of the cell structure element actin and the cell's ability to move. Thus, the affected immune cells can no longer fulfill their function.

"We speculate that the negative effect of Nef on the mobility of T-helper cells has far reaching consequences for the efficient formation of antibodies by B-lymphocytes in the patient. The mechanism we have described could be involved in the increasingly observed malfunction of B-lymphocytes in AIDS patients", explains Professor Fackler. Up to now, Nef has not been a target of antiviral therapy. Since one of the first molecular mechanisms has now been decoded, however, and the importance of Nef for the disease has become clearer, this could change in the future.


'/>"/>

Contact: Prof. Dr. Oliver T. Fackler
Oliver_Fackler@med.uni-heidelberg.de
062-215-61322
University Hospital Heidelberg
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Bursts of waves drive immune system soldiers toward invaders
2. Key to out-of-control immune response in lung injury found
3. Flies can turn off their immune response
4. How the plant immune system can drive the formation of new species
5. Auto immune response creates barrier to fertility; could be a step in speciation
6. Immune police recognize good and bad guys in the body
7. Agent that triggers immune response in plants is uncovered
8. Immune cells promote blood vessel formation in mouse endometriosis
9. Influenza vaccine causes weaker immune response for children of rural Gabon than in semi-urban areas
10. The PIN codes of the immune system can be hacked
11. Pathogens use previously undescribed mechanism to sabotage host immune system
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
How HIV cripples immune cells
(Date:7/7/2015)... MOUNTAIN VIEW, Calif. , July 7, 2015 ... mobile biometrics market, Frost & Sullivan recognizes Credence ... & Sullivan Entrepreneurial Company of the Year ... product suite to aid in its mission of ... and under-recognized populations globally. As Credence ID was ...
(Date:7/2/2015)... , June 25, 2015 ... of the "Next Generation Biometrics Market by Application, ... report to their offering. The next ... by 2020, at a CAGR of 17.9% between 2015 ... leading application for the market. Safran SA ...
(Date:6/30/2015)... Pa. , June 30, 2015 ... the company as CEO to help further develop Genisphere,s ... wealth of partnering experience, having spent much of the ... including Therakine, Amgen, Baxter Bioscience, and Johnson & Johnson. ... focus on Technology and Biotech Corporate Finance. He graduated ...
Breaking Biology News(10 mins):Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 2Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 3Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 4Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 5Next Generation Biometrics Market 2015 - Global Forecast to 2020 with Safran, NEC, 3M Cogent, Fujitsu & Suprema Dominating the $24 Billion Market 2Next Generation Biometrics Market 2015 - Global Forecast to 2020 with Safran, NEC, 3M Cogent, Fujitsu & Suprema Dominating the $24 Billion Market 3Genisphere Appoints New CEO, Thomas Bliss 2Genisphere Appoints New CEO, Thomas Bliss 3
... at Loyola University Chicago Stritch School of Medicine have ... Institutes of Health to study vitamin D deficiency in ... relation between low vitamin D levels and risks for ... Evidence from numerous previous studies is "inconclusive and needs ...
... WEST LAFAYETTE, Ind. - A Purdue University researcher has ... might lead to improvements in that and other crops. ... landscape architecture, wanted to understand the relationship between natural ... plant architecture, specifically plant height. Schulz said corn could ...
... at the University of North Carolina at Chapel Hill have ... different viruses in an effort to create the ultimate vehicle ... investigators found no side effects from using a "chimeric" virus ... patients with muscular dystrophy. "This trial demonstrates that gene ...
Cached Biology News:Loyola receives NIH grant to study vitamin D deficiency in African populations 2Stronger corn? Take it off steroids, make it all female 2Stronger corn? Take it off steroids, make it all female 3Clinical trial for muscular dystrophy demonstrates safety of customized gene therapy 2
(Date:7/29/2015)... (Q2 2015: +14% CER / 20% of sales) led the regional performance ... , as well as solid contributions from Korea, India ... Middle East / Africa (Q2 ... , Turkey and the United Kingdom ... 11%, excluding U.S. HPV sales, on demand across all customer classes. The top ...
(Date:7/29/2015)...  AsureQuality and Ubiquitome have agreed to collaborate ... food and primary production sectors. The collaboration will ... the Freedom4. AsureQuality provides quality assurance ... shelf for producers, processors and Competent Authorities around ... control and pest management and surveillance programmes. ...
(Date:7/29/2015)... ... July 29, 2015 , ... ... announced its GHS Label Guide . To align chemical container labeling with ... guide includes explanations of label components, an example of an accurate label, and ...
(Date:7/29/2015)... , July 29, 2015  Pfenex Inc. (NYSE ... financial results will be released on Thursday, August 13, ... Eastern Time, Pfenex management will host a conference call ... update.  A press release outlining the financial results and ... call. Please call 1-866-376-8058 (US) or 1-412-542-4131 ...
Breaking Biology Technology:QIAGEN Reports Results for Second Quarter and First Half of 2015 2QIAGEN Reports Results for Second Quarter and First Half of 2015 3QIAGEN Reports Results for Second Quarter and First Half of 2015 4QIAGEN Reports Results for Second Quarter and First Half of 2015 5QIAGEN Reports Results for Second Quarter and First Half of 2015 6QIAGEN Reports Results for Second Quarter and First Half of 2015 7QIAGEN Reports Results for Second Quarter and First Half of 2015 8QIAGEN Reports Results for Second Quarter and First Half of 2015 9QIAGEN Reports Results for Second Quarter and First Half of 2015 10AsureQuality and Ubiquitome Partner on Applications for Mobile Molecular Food Safety Testing 2Brady Announces a New GHS Label Guide 2Pfenex To Report Second Quarter 2015 Results and Provide Business Update on Thursday, August 13, 2015 2
... announces that a new market research report is available ... http://www.reportlinker.com/p0288102/US-Vaccines-Market.html ... for vaccines is forecast to increase 5.5 percent annually ... has experienced dramatic growth due to increasing routine seasonal ...
... Fibrocell Science, Inc. (OTC Bulletin Board: ... of autologous cell therapies for aesthetic, medical and scientific ... , M.D., Ph.D., to its scientific advisory board. In ... Dr. Gruenwald is a biotechnology and genetic research expert. ...
... IRVINE, Calif., Sept. 7 ChromaDex Corporation (OTC Bulletin ... company which provides novel and innovative ingredients to the ... a clinical study at The University of Mississippi for ... based on the grant of an exclusive worldwide license ...
Cached Biology Technology:Reportlinker Adds US Vaccines Market 2Reportlinker Adds US Vaccines Market 3Reportlinker Adds US Vaccines Market 4Reportlinker Adds US Vaccines Market 5Reportlinker Adds US Vaccines Market 6Reportlinker Adds US Vaccines Market 7Fibrocell Science, Inc. Names Biotechnology and Genetic Research Expert Stefan Gruenwald, M.D., Ph.D., to Scientific Advisory Board 2Fibrocell Science, Inc. Names Biotechnology and Genetic Research Expert Stefan Gruenwald, M.D., Ph.D., to Scientific Advisory Board 3ChromaDex Commences a Clinical Trial on pTeroPure™ Pterostilbene 2ChromaDex Commences a Clinical Trial on pTeroPure™ Pterostilbene 3
Bag-1 (K-20)...
... PGE2-d4 contains 4 deuterium atoms at ... It is intended for use as an ... E2 (PGE2) by GC- or LC-mass spectrometry. ... products of arachidonic acid and one of ...
Deletions, insertions or substitutions. Mutations in plasmids of size up to 15 kb. Single or multiple mutations...
Request Info...
Biology Products: