Navigation Links
How HIV cripples immune cells
Date:9/16/2009

ly on their mobility.

Short-circuiting of two different signal paths in the cell by Nef

The researchers examined the movement of cells in living zebra fish embryos and were able to show that cell mobility is inhibited by the HIV Nef protein. As they continued their experiments on cell cultures, they were able to explain the underlying mechanism: Nef causes an enzyme that normally has nothing to do with cell mobility to deactivate a regulator for actin regeneration. Nef therefore causes a short-circuit of two cellular mechanisms, thus inhibiting the reorganization of the cell structure element actin and the cell's ability to move. Thus, the affected immune cells can no longer fulfill their function.

"We speculate that the negative effect of Nef on the mobility of T-helper cells has far reaching consequences for the efficient formation of antibodies by B-lymphocytes in the patient. The mechanism we have described could be involved in the increasingly observed malfunction of B-lymphocytes in AIDS patients", explains Professor Fackler. Up to now, Nef has not been a target of antiviral therapy. Since one of the first molecular mechanisms has now been decoded, however, and the importance of Nef for the disease has become clearer, this could change in the future.


'/>"/>

Contact: Prof. Dr. Oliver T. Fackler
Oliver_Fackler@med.uni-heidelberg.de
062-215-61322
University Hospital Heidelberg
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Bursts of waves drive immune system soldiers toward invaders
2. Key to out-of-control immune response in lung injury found
3. Flies can turn off their immune response
4. How the plant immune system can drive the formation of new species
5. Auto immune response creates barrier to fertility; could be a step in speciation
6. Immune police recognize good and bad guys in the body
7. Agent that triggers immune response in plants is uncovered
8. Immune cells promote blood vessel formation in mouse endometriosis
9. Influenza vaccine causes weaker immune response for children of rural Gabon than in semi-urban areas
10. The PIN codes of the immune system can be hacked
11. Pathogens use previously undescribed mechanism to sabotage host immune system
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
How HIV cripples immune cells
(Date:6/1/2015)... -- According to a new market research ... (Touch-based & Touchless), Application (Consumer Electronics, Automotive, & Others), ... Global Forecast to 2020", published by MarketsandMarkets, the Gesture ... $23.55 Billion by 2020, at a CAGR of 28.23% ... market data T ables and   86   ...
(Date:6/1/2015)... , June 1, 2015 ... Generation Biometrics Market by Application (Government, Military & ... & Immigration, and Security), Technology (Face Recognition, Fingerprint ... Recognition, Vein Recognition, and Others), Function (Contact and ... , Europe , APAC, Row) ...
(Date:5/29/2015)... DUBLIN , May 28, 2015 ... the addition of the "Facial Recognition Market ... User - Global Forecast to 2020" report ... years, have seen facial recognition technology become more ... technology to gain traction and investment from the ...
Breaking Biology News(10 mins):Gesture Recognition & Touchless Sensing Market Worth $23.55 Billion by 2020 2Gesture Recognition & Touchless Sensing Market Worth $23.55 Billion by 2020 3Gesture Recognition & Touchless Sensing Market Worth $23.55 Billion by 2020 4Next Generation Biometrics Market Worth $24,448.84 Million by 2020 2Next Generation Biometrics Market Worth $24,448.84 Million by 2020 3Next Generation Biometrics Market Worth $24,448.84 Million by 2020 4Global advanced Facial Recognition Market Expected to Grow From $2.77 Billion in 2015 to $6.19 Billion in 2020, at an Estimated CAGR of 17.4% 2
... in women is highly recognized by the public. Less appreciated is ... million males have been diagnosed with osteoporosis and another three million ... thought to be major factors behind bone fractures in both sexes. ... levels of the testosterone are known to be at risk. Low ...
... of Public Health researchers have found that older adolescents ... engage in healthy activities such as exercising, eating fruits ... larger quantities of sweetened beverages and fast food, were ... less than teens without TVs in their bedrooms. ...
... Simple environmental enrichment and increased social stress can both ... new monkey research at Wake Forest University School of ... shown that social rank whether animals are dominant ... the amount of cocaine that monkeys will self-administer. Housed ...
Cached Biology News:Testosterone replacement theraphy beneficial in men 60 and older 2Testosterone replacement theraphy beneficial in men 60 and older 3U of M research finds teens who have TV in their bedroom are less likely to engage in healthy habits 2Environmental enrichment can reduce cocaine use, researchers find 2
(Date:6/2/2015)... 2015   Hospira, Inc. (NYSE: HSP ... its partner, Celltrion – a global biopharmaceutical company – has ... Agency in Brazil – for ... use in Brazil . The medication ... sells biosimilar infliximab in 26 European countries and in ...
(Date:6/2/2015)... June 02, 2015 “Stem Cell Therapy to ... mainstream, and it is used often as an adjunct to ... practitioners are not yet aware or comfortable enough with the ... is most often reserved for the last resort cases - ... can barely lift a paw to get around. It is ...
(Date:6/2/2015)... 2015   Intrexon Corporation (NYSE: ... today the appointment of Olivier R. Jarry ... Mr. Jarry will lead the expansion of Intrexon,s programs ... for consumer markets.  Mr. Jarry ... in leading global life sciences and consumer health ...
(Date:6/2/2015)... , June 2, 2015  RXi ... biotechnology company focused on discovering and developing ... dermatology and ophthalmology, today announced that Dr. ... will present at the 23 rd ... world congress will include in-depth presentations by ...
Breaking Biology Technology:ANVISA Approves First Infliximab Biosimilar in Brazil 2ANVISA Approves First Infliximab Biosimilar in Brazil 3ANVISA Approves First Infliximab Biosimilar in Brazil 4ANVISA Approves First Infliximab Biosimilar in Brazil 5VetStem Biopharma, Proudly Announces a New Long Term Partnership with VCA West Los Angeles in Support of Stem Cell Therapy Training and Clinical Opportunities. 2VetStem Biopharma, Proudly Announces a New Long Term Partnership with VCA West Los Angeles in Support of Stem Cell Therapy Training and Clinical Opportunities. 3Intrexon Announces New Sector Leader 2Intrexon Announces New Sector Leader 3RXi Pharmaceuticals to Present at the 23rd World Congress of Dermatology 2RXi Pharmaceuticals to Present at the 23rd World Congress of Dermatology 3RXi Pharmaceuticals to Present at the 23rd World Congress of Dermatology 4
... DIEGO, Nov. 11 Accumetrics, Inc. has announced the,appointment ... for the company.,Dr. Young will serve in a part-time ... Medicine and Director of the Cardiovascular,Innovations Program at The ... as the main liaison to practicing clinicians, as well ...
... Accera, Inc., a,biotechnology company delivering breakthrough therapies in ... a Series C financing,round of $35 million (euro ... of this financing will be used to begin ... (previously known as Ketasyn), which,is scheduled to launch ...
... Enterprises, LLC (, http://www.CJPS-Enterprises.com ) announced that ... its services to leverage companies, intellectual property (IP) ... value of their intangible assets.,This customized service is ... is a firm that specializes in growing,companies in ...
Cached Biology Technology:Accumetrics Appoints John J. Young, MD Chief Medical Officer 2Accera, Inc. Completes $35 Million Series C Financing 2CJPS Enterprises Provides New Strategies To Create Additional Revenues for Companies with Intellectual Property 2
... is a new product number, ... product number. If showing no ... the old Sigma-Aldrich number (C6921) ... assistance. Mfr Desig: Corning ...
A cost-effective serum for general cell growth requirements. All serum is collected from calves aged 10 days old or less....
... This CLS number is ... to easily match Cornings product ... yet, please order under the ... contact customer service for assistance. ...
... culture scale-up, these culture chambers produce cell ... 9 range and are useful alternatives ... • High mechanical • strength and structural ... shipping • Certified nonpyrogenic and sterilized by ...
Biology Products: