Navigation Links
House Ear Institute, TGen and Belgian researchers identify gene in age-related hearing loss
Date:12/2/2008

LOS ANGELES, Calif. Dec. 2, 2008 Presbycusis, or age-related hearing loss, accounts for 30 percent of all hearing loss. So, why do some people lose their hearing as they get older but other people can still hear a pin drop?

The answer may be in a study released online in the journal Human Molecular Genetics. Advance access is available online at http://hmg.oxfordjournals.org/papbyrecent.dtl.

"This is the first ever and largest genome-wide association study for age-related hearing loss," said Rick Friedman, M.D., Ph.D., lead author and House Ear Institute principal investigator and surgeon at the House Clinic.

The study was conducted in collaboration with colleagues at the Phoenix-based Translational Genomics Research Institute (TGen), Affymetrix in Santa Clara, Calif., and the University of Antwerp, Belgium. It uncovered several genes, but one gene stands out and is believed to put people at risk for hearing loss as they age.

They discovered a common variant in the GRM7 gene, which the research team believes may be associated with susceptibility to glutamate excitotoxicity and hearing loss.

It is the overexpression of glutamate that causes damage to the inner and outer hair cells in the inner ear leading to age-related hearing loss.

"Finding the genetic causes of age-related hearing loss could lead to treatments that would bring relief to millions of people worldwide who now suffer from social isolation, depression and even cognitive impairment as a result of not being able to properly understand what others are saying,'' said Dr. Matthew Huentelman, an investigator in TGen's Neurogenomics Division and one of the lead authors.

Researchers believe this paper's findings represent important and significant progress in the efforts to discover the origins of presbycusis.

"We have known for a long time that genes play an important role in presbycusis, but until now genetic research has lagged behind compared to other important diseases," said Guy Van Camp, director of the Hereditary Deafness Laboratory and professor, University of Antwerp, Belgium. "The identification of GRM7 is a very exciting result, as it may provide insights in the development of the disease."

The study participants were Caucasian, ages 53 to 67, and the samples were collected at eight centers in six nations throughout Europe from population registries or audiological consultations. The team of investigators analyzed the samples and identified genetic risks.

In the lab, the research team used Affymetrix GeneChip Human Mapping 500K to score markers across the entire genome of more than 2,000 samples.

Friedman said the next step is developing a laboratory model to test pharmaceuticals for possible treatment of presbycusis in the future.


'/>"/>

Contact: Steve Yozwiak
syozwiak@tgen.org
602-343-8704
The Translational Genomics Research Institute
Source:Eurekalert

Related biology news :

1. Household exposure to toxic chemicals lurks unrecognized, researchers find
2. MIT: Safe storage of greenhouse-gas carbon dioxide
3. MIT analysis shows how cap-and-trade plans can cut greenhouse emissions
4. Potent greenhouse gas more prevalent in atmosphere than previously assumed
5. Greenhouse gas auction revenues can help cut Md. electric use significantly, says study
6. Could Dr. House be replaced by a computer?
7. Carbon dioxide scrubber captures greenhouse gases
8. 8 National Medals of Science awardees to be honored at gala, then the White House
9. bioMETRX New Product to be Sold at Major National Warehouse Club
10. White House announces 2007 National Medal of Science laureates
11. MSU to create genomic clearinghouse for biofuel crops
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/3/2016)... , February 4, 2016 --> ... to SEK 1,351.5 M (105.0), up 1,187% compared with fourth quarter of ... amounted to SEK 517.6 M (loss: 30.0). Earnings per share ... activities was SEK 537.4 M (neg: 74.7). , ... , Revenues amounted to SEK 2,900.5 M (233.6), up 1,142% compared with ...
(Date:2/2/2016)... NEW YORK , Feb. 2, 2016 /PRNewswire/ ... analysis of the bioinformatic market by reviewing the ... computer enabled tools that drive the field forward. ... report to: Identify the challenges and opportunities ... service providers and software solution developers, as well ...
(Date:2/1/2016)... Rising sales of consumer electronics ... intuitive gesture control market size ... consumer electronics coupled with new technological advancements to drive ... through 2020   --> ... advancements to drive global touchfree intuitive gesture control market ...
Breaking Biology News(10 mins):
(Date:2/3/2016)... 2016   ViaCyte, Inc ., a leading, ... stem cell-derived islet replacement therapy for the treatment ... announced that ViaCyte and Janssen Biotech, Inc., one ... Johnson, have agreed to consolidate the assets of ... provides ViaCyte with an exclusive license to all ...
(Date:2/3/2016)... -- With the growing need for better therapeutics, and ... such as monoclonal antibodies, recombinant protein therapeutics and ... are in high demand. Conventionally expression systems were ... of these therapeutics. However, due to issues with ... approaches and novel expression systems are currently being ...
(Date:2/3/2016)... Mass., Feb. 3, 2016 Harvard Apparatus ... biotechnology company developing bioengineered organ implants for life-threatening ... announced that CEO Jim McGorry , will ... Conference on Tuesday, February 9, 2016 at ... City . HART,s presentation will be webcast ...
(Date:2/3/2016)... ... February 03, 2016 , ... Aerocom, ... office dedicated to the North American healthcare market. , Aerocom Healthcare, LLC will ... The company will provide new pneumatic tube systems or expand existing systems ...
Breaking Biology Technology: