Navigation Links
Hot peppers really do bring the heat
Date:8/6/2008

Chili peppers can do more than just make you feel hot, reports a study in the August 1 Journal of Biological Chemistry; the active chemical in peppers can directly induce thermogenesis, the process by which cells convert energy into heat.

Capsaicin is the chemical in chili peppers that contributes to their spiciness; CPS stimulates a receptor found in sensory neurons, creating the heat sensation and subsequent reactions like redness and sweating.

Now, Yasser Mahmoud has found that capsaicin can create "heat" in a more direct manner by altering the activity of a muscle protein called SERCA. Normally, muscle contraction initiates following the release of a wave of calcium ions from a compartment called the sarcoplasmic reticulum (SR); SERCA then actively pumps the calcium back into the SR (using ATP energy), causing muscle relaxation and renewing the cycle.

Capsaicin, however, can attach to SERCA and "uncouple" this pumping activity; that is, the protein still burns ATP energy but doesn't use it to pump calcium. Instead, all the ATP energy is given off as heat. This uncoupling, known as thermogenesis, is one important method of staying warm and is most often seen in hibernating animals.

Mahmoud notes that capsaicin is the first natural compound known to augment the thermogenesis process .

These findings further explain how capsaicin intake can increase metabolism and body temperature. And although these studies required relatively high amounts of capsaicin (probably more than someone could eat), the structure of capsaicin could be used as a model to design more potent compounds that might have clinical use such as treating hypothermia.


'/>"/>

Contact: Nick Zagorski
nzagorski@asbmb.org
301-634-7366
American Society for Biochemistry and Molecular Biology
Source:Eurekalert

Page: 1

Related biology news :

1. Early bird project really gets the worm
2. When is a stem cell not really a stem cell?
3. New ORNL process brings nanoparticles into focus
4. First-ever symposium brings together military and civilian medical experts
5. World-class environment vision to bring back the species
6. Dinosaur diggers bring mobile lab, new techniques to Eastern Montana
7. Global Biopact on biofuels can bring benefits to both rich and poor nations
8. Astronomy technology brings nanoparticle probes into sharper focus
9. Man-made changes bring about new epoch in Earths history
10. Biomass production -- careful planning can bring many benefits
11. Chemist Brings SAFETY Act Expertise to Homeland Security Firm
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... of Chicago is creating a new professorship in ... University,s Institute for Molecular Engineering and the Marine ... from the Millicent and Eugene Bell Foundation., The ... within the Institute for Molecular Engineering. That endowed ... at the MBL,s Eugene Bell Center for Regenerative ...
(Date:7/11/2014)... researchers from The Chinese University of Hong Kong, BGI ... soybean linked to salt tolerance, with implication for improving ... study published online in Nature Communications provides ... crop improvement. , Soybean is an important crop for ... soybeans have less genetic diversities than their wild counterparts. ...
(Date:7/11/2014)... two different ways that allow unprecedented experimental insights ... of oxygen molecules in photosynthesis. The two studies ... Nature Communications . , "The new knowledge will ... oxidation, which are key components for building artificial ... energy in fuels like hydrogen, ethanol or methanol," ...
Breaking Biology News(10 mins):New professorship in tissue engineering links molecular engineering, marine biology 2BGI reports a novel gene for salt tolerance found in wild soybean 2Molecular snapshots of oxygen formation in photosynthesis 2
... AMES, Iowa A national panel led ... effort to research and develop technologies that capture, ... ecosystems, economic development and national security. The ... recently met for the first time in Chicago. ...
... of a massive set of mammal data accessed through ... helped quantify the influence of various environmental factors on ... A team of Israeli scientists based at the Technion ... detailed coordinates in the ,lower 48, states of the ...
... are increasingly using live cells in their treatments: in ... in stem cell therapies and following severe burns. Cells ... burned skin, eliminating immune deficiencies, repairing degenerated cartilage or ... by the immune system. These cells have to be ...
Cached Biology News:Iowa State engineers establish national panel to advance a carbon negative economy 2Iowa State engineers establish national panel to advance a carbon negative economy 3Use of GBIF helps clarify environment-species links 2Plasma in bags 2
(Date:7/11/2014)... 2014  Researchers have pioneered a revolutionary new ... technology, called Virtual Finger, allows scientists to move ... and synapses using the flat surface of their ... imaging studies orders of magnitude more efficient, saving ... across many areas of experimental biology. The software ...
(Date:7/10/2014)... Ohio (PRWEB) July 10, 2014 Understanding ... ion channel-expressing cell lines, and the gap that currently ... cells that expand its industry-leading portfolio of validated ion ... on ion channel-expressing cell lines, as ion channels control ... to control this activity creates the potential to treat ...
(Date:7/10/2014)... EvoDerma ’s NOOME Anti-Aging Motion has been upgraded ... with a second treatment cup to help prevent and smooth ... is thinner on the edges for a softer contact with ... uneven surfaces on the face, neck and décolleté. Choose to ... areas such as the cheeks and neck, or opt for ...
(Date:7/10/2014)... , July 10, 2014 /PRNewswire-iReach/ -- Tute ... interpretation, today announced an agreement with Lineagen, ... for Lineagen,s NextStep Dx PLUS.  Lineagen, ... and neurological disorders, currently offers FirstStep Dx ... testing service used by healthcare providers as ...
Breaking Biology Technology:Virtual Finger Enables Scientists To Navigate And Analyze 3D Images Of Complex Biological Structures 2Virtual Finger Enables Scientists To Navigate And Analyze 3D Images Of Complex Biological Structures 3Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 2Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 3Introducing a New Bonus Treatment Cup for EvoDerma’s NOOME Anti-Aging Motion 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 3Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 4
... FRANCISCO, Feb. 22, 2011 Jennerex, Inc. ... the appointment of James M. Burke, M.D. to the ... will be responsible for all global clinical research activities ... Burke has been working with Jennerex in an advisory ...
... Feb. 22, 2011 /PRNewswire-Asia-FirstCall/ -- China Cord Blood Corporation (NYSE: ... and largest cord blood banking operator in China, today announced ... held on February 18, 2011, in Hong Kong. ... Chen and Mark Chen to serve on the Board of ...
... , This release is available in French . ... been a huge amount of groundwater pollution worldwide, and this has ... Sherwood Lollar, Canada Research Chair in Isotope Geochemistry of the Earth ... Lollar is taking part in the THINK CANADA Press Breakfast Sunday ...
Cached Biology Technology:Jennerex Appoints James M. Burke, M.D. Vice President, Clinical Research 2China Cord Blood Corporation Announces Results of 2010 Annual General Meeting 2Water, water, everywhere... but is it safe to drink? 2
... [RS17 ] to PRKAR2 cAMP is ... of cellular functions. cAMP exerts its effects ... which transduces the signal through phosphorylation of ... AMPK is a tetramer composed of two ...
The large Dodeca stainer shaking rack holds the staining trays in the large Dodeca stainer....
...
...
Biology Products: