Navigation Links
Hot peppers really do bring the heat
Date:8/6/2008

Chili peppers can do more than just make you feel hot, reports a study in the August 1 Journal of Biological Chemistry; the active chemical in peppers can directly induce thermogenesis, the process by which cells convert energy into heat.

Capsaicin is the chemical in chili peppers that contributes to their spiciness; CPS stimulates a receptor found in sensory neurons, creating the heat sensation and subsequent reactions like redness and sweating.

Now, Yasser Mahmoud has found that capsaicin can create "heat" in a more direct manner by altering the activity of a muscle protein called SERCA. Normally, muscle contraction initiates following the release of a wave of calcium ions from a compartment called the sarcoplasmic reticulum (SR); SERCA then actively pumps the calcium back into the SR (using ATP energy), causing muscle relaxation and renewing the cycle.

Capsaicin, however, can attach to SERCA and "uncouple" this pumping activity; that is, the protein still burns ATP energy but doesn't use it to pump calcium. Instead, all the ATP energy is given off as heat. This uncoupling, known as thermogenesis, is one important method of staying warm and is most often seen in hibernating animals.

Mahmoud notes that capsaicin is the first natural compound known to augment the thermogenesis process .

These findings further explain how capsaicin intake can increase metabolism and body temperature. And although these studies required relatively high amounts of capsaicin (probably more than someone could eat), the structure of capsaicin could be used as a model to design more potent compounds that might have clinical use such as treating hypothermia.


'/>"/>

Contact: Nick Zagorski
nzagorski@asbmb.org
301-634-7366
American Society for Biochemistry and Molecular Biology
Source:Eurekalert

Page: 1

Related biology news :

1. Early bird project really gets the worm
2. When is a stem cell not really a stem cell?
3. New ORNL process brings nanoparticles into focus
4. First-ever symposium brings together military and civilian medical experts
5. World-class environment vision to bring back the species
6. Dinosaur diggers bring mobile lab, new techniques to Eastern Montana
7. Global Biopact on biofuels can bring benefits to both rich and poor nations
8. Astronomy technology brings nanoparticle probes into sharper focus
9. Man-made changes bring about new epoch in Earths history
10. Biomass production -- careful planning can bring many benefits
11. Chemist Brings SAFETY Act Expertise to Homeland Security Firm
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/13/2015)... Jul. 13, 2015 NXT-ID, Inc. (NASDAQ: ... authentication company focused on the growing mobile commerce ... patent 62/188684 for BEHAVIORAL-DIRECTED AUTHENTIATION METHOD ... convenient and secure method to make payments.  With ... methods, introduced with its groundbreaking voice-direct payment patent ...
(Date:7/9/2015)... 2015  Unchained Labs just can,t get enough ... Avid Nano. Avid Nano designs, develops and manufactures ... Also today, Unchained Labs UNcaged the ... use protein sizing system. The pUNk is a ... size, size distribution, aggregation population and molecular weight. ...
(Date:7/8/2015)... N.J. and NEW YORK , July 8, ... Guidepoint today announced BD & Guidepoint Mentor, ... with free access to Guidepoint,s expert network services. ... are developing cutting-edge technologies to improve healthcare delivery and ... research manager, each start-up entrepreneur will be able to ...
Breaking Biology News(10 mins):NXT-ID Patents Behavior-Directed Payments 2NXT-ID Patents Behavior-Directed Payments 3NXT-ID Patents Behavior-Directed Payments 4Unchained Labs just can't get enough, acquires Avid Nano, rocks out the new pUNk! 2BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 2BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 3
... boosts in the microbial production of clean, green and ... of a new technique in synthetic biology by researchers ... Institute (JBEI). This new technique dubbed a ... in microbes during the production of fatty acid-based fuels ...
... York, N.Y. (March 26, 2012) Autism Speaks, the ... the award of new research grants totaling $1.1 million ... I are extraordinarily proud of Autism Speaks, continued funding ... open new avenues to understanding autism," said Autism Speaks ...
... and narwhals live solely in the cold waters of the ... not have always been the case. They recently described a ... belugas and narwhals that lived some 3-4 million years ago ... when its modern-day relatives evolved to live only in northern ...
Cached Biology News:New synthetic biology technique boosts microbial production of diesel fuel 2New synthetic biology technique boosts microbial production of diesel fuel 3New synthetic biology technique boosts microbial production of diesel fuel 4Autism Speaks awards $1.1 million to fund high priority studies 2Autism Speaks awards $1.1 million to fund high priority studies 3Ancient whale species sheds new light on its modern relatives 2
(Date:8/4/2015)... , ... August 05, 2015 , ... ... the “Product Handbook – the complete product line.” The handbook provides a ... “This new product handbook consolidates our complete standard product offering into an easy-to-navigate ...
(Date:8/4/2015)... Inc. (NYSE: BIOA ), a leader in renewable ... ending June 30, 2015. Highlights included: , The Sarnia ... The final cost of the Sarnia plant is projected ... high end of the estimate communicated at the onset ... The company announced commercial collaborations in two targeted industry ...
(Date:8/4/2015)... ... August 04, 2015 , ... Graphite Metallizing Corporation, ... equipment, announces the appointment of Dennis Rawle as European Director of Sales. Rawle ... recently, he was General Manager and Technical Sales Manager for pump products at ...
(Date:8/4/2015)... PORTLAND, Oregon , August 4, 2015 /PRNewswire/ ... published by Allied Market Research, titled, "World Cardiac ... global cardiac biomarker market would generate the revenue ... of 18.9% from 2015 to 2020. Cardiac Troponins ... throughout the forecast period due to high sensitivity ...
Breaking Biology Technology:Spirax Sarco releases Product Handbook 2BioAmber Reports Second Quarter 2015 Financial Results 2BioAmber Reports Second Quarter 2015 Financial Results 3BioAmber Reports Second Quarter 2015 Financial Results 4BioAmber Reports Second Quarter 2015 Financial Results 5BioAmber Reports Second Quarter 2015 Financial Results 6BioAmber Reports Second Quarter 2015 Financial Results 7BioAmber Reports Second Quarter 2015 Financial Results 8BioAmber Reports Second Quarter 2015 Financial Results 9BioAmber Reports Second Quarter 2015 Financial Results 10BioAmber Reports Second Quarter 2015 Financial Results 11BioAmber Reports Second Quarter 2015 Financial Results 12Dennis Rawle Joins Graphite Metallizing Corporation 2Cardiac Biomarker Market is Expected to Reach $2,085.9 Million by 2020 2Cardiac Biomarker Market is Expected to Reach $2,085.9 Million by 2020 3Cardiac Biomarker Market is Expected to Reach $2,085.9 Million by 2020 4Cardiac Biomarker Market is Expected to Reach $2,085.9 Million by 2020 5
... SAN DIEGO, March 6 Cadence Pharmaceuticals,Inc. (Nasdaq: ... in-licensing,developing and commercializing proprietary product candidates principally,for use ... will release its,fourth quarter and full year ended ... market on Wednesday, March 12, 2008., Cadence ...
... PICK: Pinpoint accuracy: DNA vaccines that home in on ... pursued to develop new vaccines against infectious diseases is ... a DNA vaccine, the body converts the information in ... immune response. However, current DNA vaccines induce relatively weak ...
... Elsevier, the world-leading publisher of scientific, technical and ... Materials 2009: The First International Conference on Multifunctional, ... Tours, France, 15-19 March 2009. , Research ... growth in published papers in recent years with ...
Cached Biology Technology:Cadence Pharmaceuticals to Host Conference Call and Webcast to Discuss Fourth Quarter and Full Year 2007 Financial Results and Clinical Program Overview on March 12, 2008 2JCI online early table of contents: March 6, 2008 2JCI online early table of contents: March 6, 2008 3JCI online early table of contents: March 6, 2008 4Hybrid materials: Exciting interdisciplinary field offering future solutions for industry 2
Anti-Human Factor XIII HRPO (Polyclonal) (sheep IgG)...
... Mouse monoclonal [F30 P7 D7 ... for all tested applications). ... conjugated to Ovalbumin, corresponding to amino ... Entrez Gene ID: ...
E2F-5...
LAB/Probe Mouse-Rabbit DAB Kit...
Biology Products: