Navigation Links
Hot on the trail of metabolic diseases and resistance to antibiotics
Date:3/28/2012

ABC transporters are membrane proteins that actively pump a wealth of molecules across the membrane. Over 40 different ABC transporters perform vital functions in humans. Genetic defects in ABC transporters can trigger metabolic diseases such as gout, neonatal diabetes or cystic fibrosis, and certain ABC transporters also cause resistance to a wide range of drugs. In tumor cells, increased amounts of ABC transporters that pump chemotherapeutic substances out of the cell are often produced, thus rendering anticancer drugs ineffective. Analogous mechanisms play a key role in many pathogenic bacteria: ABC transporters carry antibiotics out of the cell multi-resistant bacteria are the result.

Despite their major importance in biology and medicine, so far the atomic structure of only a few ABC transporters has been decoded. Now, under the supervision of Markus Seeger and Professor Markus Grtter, PhD student Michael Hohl and senior scientist Christophe Briand have succeeded in cracking the atomic structure of the new ABC transporter "TM287/288".

Illuminating asymmetry

The membrane protein originates from a thermophilic bacterium. Compared to structures already known, "TM287/288" has two different protein chains that assemble into a heterodimer. About half of the 40 human ABC transporters are heterodimers. "The asymmetries discovered enable us to consider the role of ABC transporters in a new light," explains Seeger. "In the longer term, our results could help develop new medication against multi-resistant bacteria or tumors that are difficult to treat. They also make new approaches to curing or alleviating hereditary diseases possible," concludes Grtter.


'/>"/>
Contact: Dr. Markus Seeger
m.seeger@bioc.uzh.ch
41-446-355-552
University of Zurich
Source:Eurekalert

Page: 1

Related biology news :

1. On the trail of a targeted therapy for blood cancers
2. Lead-flapping objects experience less wind resistance than their trailing counterparts
3. Dictyostelium cells shown to lay breadcrumb trail as first step in multicellular formation
4. Trailblazing rural community shows green heating oil a viable option
5. Lake-bed trails tell ancient fish story
6. Scientist Tim Flannery is first Austrailian to receive Joseph Leidy Award
7. Following trail of cell death in epilepsy patients to find ways to preserve brain health
8. Researchers on the trail of a treatment for cancer of the immune system
9. Limits for mountain trail use identified
10. Following the trail of conservation successes
11. On the trail of biomarkers and signalling substances with major instrumentation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/26/2016)... LONDON , April 26, 2016 ... EdgeVerve Systems, a product subsidiary of Infosys (NYSE: ... a partnership to integrate the Onegini mobile security ... (Logo: http://photos.prnewswire.com/prnh/20151104/283829LOGO ) The ... enhanced security to access and transact across channels. ...
(Date:4/19/2016)... The new GEZE SecuLogic access ... "all-in-one" system solution for all door components. It can ... door interface with integration authorization management system, and thus ... minimal dimensions of the access control and the optimum ... offer considerable freedom of design with regard to the ...
(Date:4/15/2016)... 15, 2016 Research and ... Biometrics Market 2016-2020,"  report to their offering.  , ... , ,The global gait biometrics market is expected ... the period 2016-2020. Gait analysis generates ... be used to compute factors that are not ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... June 23, 2016 , ... Charm Sciences, Inc. ... test has received AOAC Research Institute approval 061601. , “This is another AOAC-RI ... stated Bob Salter, Vice President of Regulatory and Industrial Affairs. “The Peel Plate ...
(Date:6/23/2016)... ... 23, 2016 , ... Supplyframe, the Industry Network for electronics ... Lab . Located in Pasadena, Calif., the Design Lab’s mission is to bring ... designed, built and brought to market. , The Design Lab is Supplyframe’s physical ...
(Date:6/23/2016)...  Blueprint Bio, a company dedicated to identifying, protecting ... has closed its Series A funding round, according to ... "We have received a commitment from Forentis Fund that ... meet our current goals," stated Matthew Nunez . ... complete validation on the current projects in our pipeline, ...
(Date:6/23/2016)... ... 23, 2016 , ... Regulatory Compliance Associates® Inc. (RCA), a ... webinar on Performing Quality Investigations: Getting to Root Cause. This ... charge. , Incomplete investigations are still a major concern to the Regulatory Authorities ...
Breaking Biology Technology: