Navigation Links
Hot on the trail of cellular metabolism
Date:3/4/2014

UCPs or uncoupling proteins are present in mitochondria, the powerhouse of each cell in the body. The functions of most of the five known UCPs remain mysterious (UCP2-UCP5), whereby only the distinct function for UCP1 has thus far been discovered. UCP1 is responsible for heat production when muscle activity is deficient such as is the case with babies and animals in hibernation. The research team at the Department of Physiology and Biophysics at the University of Veterinary Medicine in Vienna were able to provide a fundamental explanatory concept for the function of UCP2 and UPC4 for the first time. Each of these proteins are involved in different types of cell metabolism.

UCP2 in Stem Cells and Cancer Cells

In earlier studies of immune cells, lead author, Anne Rupprecht, had already shown that UCP2 could be involved in increased metabolism. Embryonic stem cells precisely exhibit such an increased metabolism, as they rapidly and continually divide, just like cancer cells. Rupprecht searched for various UCPs in embryonic stem cells of mice and in effect found UCP2. "Very high amounts of UCP2 even indicated an especially strong increase in metabolism. In other studies UCP2 had also already been detected in cancer cells", according to Rupprecht.

UCP4 in Nerve Cells

In contrast to UCP2, UCP4 is only found in nerve cells. Nerve cells have a completely different metabolism. They seldom divide, unlike stem cells and cancer cells. The research team of Prof. Elena Pohl therefore examined embryonic stem cells that differentiated to nerve cells in culture. On the basis of this model system, the researchers could show that UCP2 is still existent in the quickly reproducing stem cells, yet at the moment of differentiation are replaced by UPC4.

"In our work, we have examined the natural process of cell differentiation from stem cells to neurons. We know that metabolism changes during differentiation. The fact tha
'/>"/>

Contact: Elena Pohl
elena.pohl@vetmeduni.ac.at
43-125-077-4570
University of Veterinary Medicine -- Vienna
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Hot on the trail of metabolic diseases and resistance to antibiotics
2. High levels of TRAIL protein in breast milk might contribute to anticancer activity
3. 2 vortex trails with 1 stroke
4. Los Alamos science sleuth on the trail of a Martian mystery
5. Frost & Sullivan Honours Cognitec for Blazing Trails in the Face Biometrics Market with its FaceVACS-VideoScan Technology
6. Salk scientists open new window into how cancers override cellular growth controls
7. Increased fructose consumption may deplete cellular energy in patients with obesity and diabetes
8. Cellular secrets of plant fatty acid production understood
9. Make or break for cellular tissues
10. A non-invasive intracellular thermometer with fluorescent proteins has been created
11. Groundbreaking discovery of the cellular origin of cervical cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Hot on the trail of cellular metabolism
(Date:3/10/2015)... , March 10, 2015 ... "Personalized Medicine in Human Space Flight" ... Thomas J. Goodwin , Ph.D. was recently featured ... the past two years. Specifically, "Personalized Medicine ... downloaded scientific papers published in 2013 and 2014 from ...
(Date:3/10/2015)... , March 10, 2015  NXT-ID, Inc. ... or the "Company"), a biometric authentication company focused ... company,s Wocket™ smart wallet has been named the ... Rethink Modern. Rethink Modern ( http://www.rethinkmodern.com/ ... innovative items for your home and lifestyle that have a ...
(Date:3/4/2015)... , Mar. 04, 2015 Research and ... the addition of the "Global Biometrics Market ... offering. The market for biometric authentication ... of around 14% till 2020 The ... be increasing security needs, government projects and constant ...
Breaking Biology News(10 mins):"Personalized Medicine in Human Space Flight" Listed Among Most Influential Papers of 2013 and 2014 2NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 2NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 3NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 4Global Biometrics Market Forecast and Opportunities, 2020 2Global Biometrics Market Forecast and Opportunities, 2020 3
... The newly sequenced genome of a one-celled, planktonic ... the journal Nature, is already telling scientists about ... one-celled life forms to multicellular animals like ourselves. ... Science paper also released this week, University of ...
... 2008) A new study by the Bronx Zoo-based ... the Greater Yellowstone Ecosystem have apparently hopped into oblivion. ... of the journal Oryx, also speculates that the disappearance ... a variety of other prey species and their predators. ...
... the use of fully human monoclonal antibodies as a ... diseases. The most obvious advantage would be to bypass ... characterizes the use of chemerical or humanized antibodies. ... the efficient production of human monoclonal antibodies is a ...
Cached Biology News:Genome of marine organism tells of humans' unicellular ancestors 2Genome of marine organism tells of humans' unicellular ancestors 3Genome of marine organism tells of humans' unicellular ancestors 4Hareless: Yellowstone's rabbits have vanished, study says 2Is hybridoma production about to take a quantum leap forward? 2Is hybridoma production about to take a quantum leap forward? 3Is hybridoma production about to take a quantum leap forward? 4
(Date:3/27/2015)... -- WuXi PharmaTech (Cayman) Inc. (NYSE: WX ... platform company serving the global pharmaceutical, biotechnology, and ... New Drug (IND) application for WuXi MedImmune,s novel ... accepted for review by the China Food and ... 2012, MedImmune, the global biologics research and development ...
(Date:3/26/2015)... , March 26, 2015 /PRNewswire/ - SQI Diagnostics Inc. ... that after dealing with certain matters, including the appointment ... held on March 26, 2015 (the "Meeting") was adjourned, ... 8, 2015 at 11:00 a.m. ( Toronto ... been changed from that previous disclosed. The Meeting will ...
(Date:3/26/2015)... , March 26, 2015 PAREXEL ... global clinical research organization , announced ... definitive agreement to acquire all of the ... a leading provider of specialized pharmacovigilance services, ... the collection, detection, assessment, monitoring, and prevention ...
(Date:3/25/2015)... market is one of the most attractive in the ... plus a growing economy and increasing government investment in ... The Russian market is set to grow at twice ... estimates around 10-15% annually reaching an approximate market value ... Cross Green Cross provides total healthcare solutions ...
Breaking Biology Technology:Investigational New Drug Application for WuXi MedImmune's Monoclonal Antibody Accepted for Review by CFDA 2Investigational New Drug Application for WuXi MedImmune's Monoclonal Antibody Accepted for Review by CFDA 3SQI Diagnostics Inc. Announces Adjournment of Meeting 2PAREXEL Announces Execution of Definitive Agreement to Acquire Quantum Solutions India, Strengthening Leadership In Pharmacovigilance Services 2PAREXEL Announces Execution of Definitive Agreement to Acquire Quantum Solutions India, Strengthening Leadership In Pharmacovigilance Services 3PAREXEL Announces Execution of Definitive Agreement to Acquire Quantum Solutions India, Strengthening Leadership In Pharmacovigilance Services 4
... Information technology and venture funding experts will share some ... by EInnovate at the Marriott West in ... entrepreneurs and technologists with a focus on building businesses ... ,A partner in a Californian seed and early-stage technology ...
... stem-cell pioneer James Thomson, have begun construction on ... company in Madison's University Research Park . ... a venture capital firm that specializes in early-stage ... and Timothy Kamp have started Cellular Dynamics International ...
... (or maybe you're not wild about it) but you haven't yet ... to your desk. , ,It could also be that you think ... the Cubs opener or some other milestone. If you're on the ... signs may tell you that your Midwest technology job search should ...
Cached Biology Technology:Cellular Dynamics hits market with UW research heavyweights 2Ten signs tell you to look for a new tech job 2Ten signs tell you to look for a new tech job 3Ten signs tell you to look for a new tech job 4