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Hot new manufacturing tool: A temperature-controlled microbe
Date:4/16/2012

it when P. furiosus is out in the cold at 72C. This essentially gives scientists a switch for controlling lactate production: put the organism at 72C to turn on lactate production, restore it to 100C to turn it off, thus preventing the need for chemical inducers. What's more, since P. furiosus is mostly shut down at these lower temperatures, making the new product doesn't interfere with its metabolism, or vice-versa.

The lead author on the study, Michael Adams of the Department of Biochemistry & Molecular Biology at the University of Georgia, explains that this is the key benefit of this system: although P. furiosus now makes the enzyme that carries out the process, at these lower temperatures the organism's other metabolic processes don't get in the way.

"The hyperthermophile is essentially the bioreactor that contains the foreign enzymes," says Adams. P. furiosus just supplies cofactors and a cytoplasmic environment for the highly active foreign enzymes, according to Adams. This makes for a cleaner, more controllable reaction.


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Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Page: 1 2

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