Navigation Links
'Hormone therapy' for food poisoning bacteria
Date:3/28/2010

Pathogenic bacteria in the gut recognise their surroundings by detecting hormone signals from the host, which can prompt them to express lethal toxins. Intercepting these hormonal messages could be a better way to treat serious food-borne infections where antibiotics do more harm than good, explains Vanessa Sperandio speaking at the Society for General Microbiology's spring meeting in Edinburgh today.

Gut bacteria, including harmful strains of Escherichia coli and Salmonella that cause food poisoning, detect and respond to adrenaline released by the host, through a sensor called QseC embedded in the bacterial surface. When adrenaline binds to QseC, it is like toppling the first tile of a complex domino arrangement it triggers a chain of events that can ultimately result in the production of toxins.

Dr Sperandio's group at the University of Texas Southwestern Medical Center have identified a molecule, called LED209, which stops adrenaline binding to QseC. Blocking binding prevents the signalling events inside the bacterium, reducing toxin production and also hindering bacteria from attaching effectively to the epithelial cells that line the gut. When given orally to infected mice, LED209 was found to reduce the number of gut-colonising Salmonella.

The discovery could represent the first of a novel class of antimicrobial agents. "QseC is a very attractive drug target because it is present in at least 25 important animal and plant pathogens but not in mammals. This means that drugs targeting this sensor are less likely to be toxic and have the potential to be broad-spectrum (effective against several types of infection)."

Alternative treatments are needed for pathogenic E. coli and Salmonella infections, as antibiotic treatment can make the illness worse, explained Dr Sperandio. "Conventional antibiotics can trigger the SOS response in bacteria that actually enhances virulence. LED209, unlike antibiotics, does not kill or hinder E. coli growth and consequently does not promote expression of shiga toxin - which is the bacterium's defence mechanism. Instead, LED209 decreases expression of genes that encode this toxin," she said. "What is more, because this signalling system does not directly influence bacterial growth, inhibiting it may not exert a strong selective pressure for the development of resistance."


'/>"/>

Contact: Laura Udakis
l.udakis@sgm.ac.uk
44-118-988-1843
Society for General Microbiology
Source:Eurekalert

Related biology news :

1. Circadian clock controls plant growth hormone
2. Study finds Viagra increases release of key reproductive hormone
3. Scientists uncover how hormones achieve their effects
4. Obesity-related hormone is higher in children with Down syndrome
5. Effects of social isolation traced to brain hormone
6. EMD Serono launches easypod, new electronic growth hormone injection device
7. Predicting growth hormone treatment success
8. Human hormone blocker found to help prevent obesity and diabetes: study
9. Research with squirrels provides clues on hormones role in human learning
10. MU researcher links hormone replacement therapy to breast cancer
11. NC State researchers identify genes key to hormone production in plants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/22/2016)... BETHESDA, Md. , June 22, 2016  The American ... by Trade Show Executive Magazine as one of ... Summit on May 25-27 at the Bellagio in ... based on the highest percentage of growth in each of ... number of exhibiting companies and number of attendees. The 2015 ...
(Date:6/16/2016)... 16, 2016 The global ... to reach USD 1.83 billion by 2024, according ... Inc. Technological proliferation and increasing demand in commercial ... to drive the market growth.      ... The development of advanced multimodal techniques for biometric ...
(Date:6/3/2016)... Das DOTM (Department ... hat ein 44 Millionen $-Projekt ... einschließlich Personalisierung, Registrierung und IT-Infrastruktur, an Decatur ... Implementierung von Identitätsmanagementlösungen. Zahlreiche renommierte internationale Anbieter ... aber Decatur wurde als konformste und innovativste ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... June 27, 2016 , ... Newly created ... services and solutions to the healthcare market. The company's primary focus is on ... sales and marketing strategies that are necessary to help companies efficiently bring their ...
(Date:6/24/2016)... Epic Sciences unveiled a liquid biopsy ... PARP inhibitors by targeting homologous recombination deficiency (HRD) ... test has already been incorporated into numerous clinical ... Over 230 clinical trials are investigating ... PARP, ATM, ATR, DNA-PK and WEE-1. Drugs targeting ...
(Date:6/23/2016)... June 23, 2016   Boston Biomedical , ... compounds designed to target cancer stemness pathways, announced ... granted Orphan Drug Designation from the U.S. Food ... gastric cancer, including gastroesophageal junction (GEJ) cancer. Napabucasin ... to inhibit cancer stemness pathways by targeting STAT3, ...
(Date:6/23/2016)... 2016  The Prostate Cancer Foundation (PCF) is pleased to announce ... cures for prostate cancer. Members of the Class of 2016 were selected from ... Read More About the Class of 2016 PCF Young Investigators ... ... ...
Breaking Biology Technology: