PROVIDENCE, R.I. [Brown University] Given how much patients invest in in vitro fertilization (IVF), both financially and emotionally, tools to inform couples about what they might expect during their treatment can be welcome. A study by researchers at Brown University and Women & Infants Hospital shows that as the IVF cycle is beginning, a blood test for levels of a hormone called AMH, or antimullerian hormone, can help predict the number of eggs that will be harvested.
"Clinicians can measure AMH before or during ovarian stimulation to counsel couples about their likelihood of success," said Geralyn Lambert-Messerlian, professor of pathology and laboratory medicine in the Warren Alpert Medical School of Brown University and a researcher in the Division of Medical Screening and Special Testing at Women & Infants Hospital. She co-authored a paper that will be published in an upcoming issue of the American Journal of Obstetrics and Gynecology. It appeared in advance online last month.
Lead author Andrew Blazar, a physician at Women & Infants' Division of Reproductive Endocrinology and Infertility, said the finding could be useful for adjusting IVF preparations on the fly, for instance by adjusting how much follicle stimulation hormone women are receiving in the week or so before eggs are extracted for fertilization.
"The main thrust of the paper is that you can do this test even after you have begun the preparations for initiating an IVF cycle, so it allows you to modify your treatment, at least in theory, so that your probability of success would be improved," said Blazar, who is also a clinical associate professor of obstetrics and gynecology at the Alpert Medical School. "Though not proven, this approach seems like a logical way to use this new information.
"What I'm hoping is that eventually it will turn out that you can now do this test in the same cycle and not wait until you have to do another cycle, which would
|Contact: David Orenstein|