Navigation Links
Hormone in fruit flies sheds light on diabetes cure, weight-loss drug for humans
Date:8/8/2012

Winston-Salem, N.C. Manipulating a group of hormone-producing cells in the brain can control blood sugar levels in the body a discovery that has dramatic potential for research into weight-loss drugs and diabetes treatment.

In a paper published in the October issue of Genetics and available online now, neurobiologists at Wake Forest University examine how fruit flies (Drosophila) react when confronted with a decreased diet.

Reduced diet or starvation normally leads to hyperactivity in fruit flies a hungry fly buzzes around feverishly, looking for more food. That happens because an enzyme called AMP-activated kinase stimulates the secretion of the adipokinetic hormone, which is the functional equivalent of glucagon. This hormone acts opposite of insulin, as it tells the body to release the sugar, or food, needed to fuel that hyperactivity. The body uses up its energy stores until it finds food.

But when Wake Forest's Erik Johnson, an associate professor of biology, and his research team turned off AMP-activated kinase, the cells decreased sugar release and the hyperactive response stopped almost completely even in the face of starvation.

"Since fruit flies and humans share 30 percent of the same genes and our brains are essentially wired the same way, it suggests that this discovery could inform metabolic research in general and diabetes research specifically," said Johnson, the study's principal investigator. "The basic biophysical, biochemical makeup is the same. The difference in complexity is in the number of cells. Why flies are so simple is that they have approximately 100,000 neurons versus the approximately 11 billion in humans."

Medical advances as a result of this research might include:

Diabetes research: Adipokinetic hormone is the insect equivalent to the hormone glucagon in the human pancreas. Glucagon raises blood sugar levels; insulin reduces them. However, it is difficult t
'/>"/>

Contact: Katie Neal
nealkc@wfu.edu
336-758-6141
Wake Forest University
Source:Eurekalert

Page: 1 2

Related biology news :

1. BRG1 mutations confer resistance to hormones in lung cancer
2. Estrogen hormone reveals protective ability after traumatic brain injury
3. Measuring progesterone receptor expression to improve hormone-receptor-positive cancer management
4. Hormones dictate when youngsters fly the nest, says new research
5. Hormone-mimicking chemicals cause inter-species mating
6. Lighting up the plant hormone command system
7. An invasive Asian fly is taking over European fruit
8. First fruitful, then futile: Ammonites or the boon and bane of many offspring
9. Fruit flies provide new knowledge about uninhibited cell growth
10. Virginia Tech and University of Tuscia lead team to unravel origin of devastating kiwifruit bacterium
11. Commonly used herbicides seen as threat to endangered butterflies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/16/2014)... Melbourne researchers have challenged conventional thinking on how the ... new mechanism for how bowel cancer starts. , The ... maintaining and regenerating the ,crypts, that are a feature ... are involved in bowel cancer development, a controversial finding ... existence. , Using 3D imaging technologies, Dr Chin Wee ...
(Date:10/16/2014)... 2014 NXT-ID, Inc. (NASDAQ: NXTD ... authentication company focused on the growing mobile commerce market ... Wocket™, the Smart Wallet, at the 13 th ... leading global conference on the intersection of technology and ... Anderson , founder and publisher of the Strategic News ...
(Date:10/15/2014)... Gauß-Allianz has admitted Johannes Gutenberg University Mainz (JGU) ... science hub continues to maintain a significant nationwide ... , "The acceptance of Johannes Gutenberg University Mainz ... a milestone in the national and international competition ... state of Rhineland-Palatinate can be proud that Mainz ...
Breaking Biology News(10 mins):Cryptic clues drive new theory of bowel cancer development 2NXT-ID Inc. to Present at 13th Annual FiRe Conference 2NXT-ID Inc. to Present at 13th Annual FiRe Conference 3Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 2Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 3
... decrease in yield and an increase in the concentration of ... with the results of previous studies which have shown a ... seeds in high ozone, these results (to be presented at ... on 29th June 2009) could signal a significant income loss ...
... serious demands for the organism, and this is true even ... the ancestors of present marine mammals initiated their return to ... new medium. Dr. Michael Berenbrink and his colleagues at Liverpool ... delivering oxygen to the muscles during locomotion, has been modified ...
... SALT LAKE CITY, June 29, ... use computers and may let amputees control bionic limbs. But existing devices ... Utah study shows that brain signals controlling arm movements can be detected ... it. ...
Cached Biology News:Natural-born divers and the molecular traces of evolution 2Reading the brain without poking it 2Reading the brain without poking it 3Reading the brain without poking it 4Reading the brain without poking it 5
(Date:10/22/2014)... Shimadzu Scientific Instruments introduces its Open Solution QuantAnalytics(TM) ... management and clinical markets. The software increases the speed ... users to highlight and review results that are of ... to filter results by group or based on a ... need to sift through analytes of no interest. In ...
(Date:10/22/2014)... WriteResult, LLC – a premier provider of ... a team of researchers from Yale University’s School of ... to provide electronic questionnaire data collection through use of ... in May, aims to evaluate the impact of a ... and participation in urban agriculture to impact their consumption ...
(Date:10/22/2014)... Grace Century, a private equity consultancy ... the addition of Dr. Yousef “Josh” Siddiqui , ... Dr. Siddiqui will provide further healthcare expertise to its ... University College Medical School in the late ... 2001. With further certification as a General Practitioner (GP), ...
(Date:10/22/2014)... According to new market research report "Cloud Professional ... & Support), by Service Model (SaaS, PaaS, IaaS), ... & Community)) - Global Forecast to 2019", published ... Services Market into various sub-segments with an in-depth ... the drivers and restraints for this market with ...
Breaking Biology Technology:Shimadzu Releases QuantAnalytics Open Access LCMS Software Package for Clinical Applications 2myPROpad™ Topic of Panel Discussion at the Yale Food Systems Symposium 2myPROpad™ Topic of Panel Discussion at the Yale Food Systems Symposium 3Dr. Yousef Siddiqui joins the Grace Century Advisory Team 2Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 2Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 3Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 4Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 5
... and Manufacturers of America (PhRMA) President and CEO ... President Obama,s address to a joint session of ... clear that comprehensive healthcare reform is a top ... this extraordinary opportunity in our history to build ...
... YORK, Feb. 25 OLIGOMERIX, Inc. today announced the ... I grant for $323,000 from the National Institute on ... focus of the program is to develop novel biomarker ... with beta-amyloid or apolipoprotein E (apoE) proteins will be ...
... Inc. (Nasdaq: VIAP ), a biotechnology company ... of cardiovascular and metabolic disease, today announced the issuance ... for Combating Atherosclerotic Plaque", covering the use of VIA,s ... This patent is also pending in other major markets ...
Cached Biology Technology:Comprehensive Health Reform: A Must Pass This Year 2Comprehensive Health Reform: A Must Pass This Year 3OLIGOMERIX Awarded NIH Grant to Develop Novel Biomarkers for Alzheimer's Disease 2VIA Pharmaceuticals Announces Grant of New Patent on Lead Compound VIA-2291 2VIA Pharmaceuticals Announces Grant of New Patent on Lead Compound VIA-2291 3VIA Pharmaceuticals Announces Grant of New Patent on Lead Compound VIA-2291 4
... SPA Screening Assay, 5 x ... eliminate lengthy sample extraction procedures and ... 1.32-84.28 ng/ml (4-256 pmol/ml).Sensitivity: 0.65 ng/ml ... C. Category: Drug Screening & Cellular ...
...
Request Info...
... Streptavidin-Horseradish Peroxidase Conjugate, 2 ... reporter enzyme molecules for ... in situ hybridization applications.High ... & Labeling & Detection, ...
Biology Products: