Navigation Links
Hormone in fruit flies sheds light on diabetes cure, weight-loss drug for humans
Date:8/8/2012

Winston-Salem, N.C. Manipulating a group of hormone-producing cells in the brain can control blood sugar levels in the body a discovery that has dramatic potential for research into weight-loss drugs and diabetes treatment.

In a paper published in the October issue of Genetics and available online now, neurobiologists at Wake Forest University examine how fruit flies (Drosophila) react when confronted with a decreased diet.

Reduced diet or starvation normally leads to hyperactivity in fruit flies a hungry fly buzzes around feverishly, looking for more food. That happens because an enzyme called AMP-activated kinase stimulates the secretion of the adipokinetic hormone, which is the functional equivalent of glucagon. This hormone acts opposite of insulin, as it tells the body to release the sugar, or food, needed to fuel that hyperactivity. The body uses up its energy stores until it finds food.

But when Wake Forest's Erik Johnson, an associate professor of biology, and his research team turned off AMP-activated kinase, the cells decreased sugar release and the hyperactive response stopped almost completely even in the face of starvation.

"Since fruit flies and humans share 30 percent of the same genes and our brains are essentially wired the same way, it suggests that this discovery could inform metabolic research in general and diabetes research specifically," said Johnson, the study's principal investigator. "The basic biophysical, biochemical makeup is the same. The difference in complexity is in the number of cells. Why flies are so simple is that they have approximately 100,000 neurons versus the approximately 11 billion in humans."

Medical advances as a result of this research might include:

Diabetes research: Adipokinetic hormone is the insect equivalent to the hormone glucagon in the human pancreas. Glucagon raises blood sugar levels; insulin reduces them. However, it is difficult t
'/>"/>

Contact: Katie Neal
nealkc@wfu.edu
336-758-6141
Wake Forest University
Source:Eurekalert

Page: 1 2

Related biology news :

1. BRG1 mutations confer resistance to hormones in lung cancer
2. Estrogen hormone reveals protective ability after traumatic brain injury
3. Measuring progesterone receptor expression to improve hormone-receptor-positive cancer management
4. Hormones dictate when youngsters fly the nest, says new research
5. Hormone-mimicking chemicals cause inter-species mating
6. Lighting up the plant hormone command system
7. An invasive Asian fly is taking over European fruit
8. First fruitful, then futile: Ammonites or the boon and bane of many offspring
9. Fruit flies provide new knowledge about uninhibited cell growth
10. Virginia Tech and University of Tuscia lead team to unravel origin of devastating kiwifruit bacterium
11. Commonly used herbicides seen as threat to endangered butterflies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... Channel has resulted in the removal of many top ... barrel, for increasing amounts of shellfish to make up ... species at the head of the food chain are ... completely., These are some of the findings of a ... association with international non-profit research organization WorldFish. They analysed ...
(Date:7/10/2014)... start-up company housed at NJIT,s business incubator, received a ... that surgeons will use to staunch bleeding during brain ... surgical site, and the natural bio-polymer solutions in the ... within 30 seconds. , The gel can shorten ... translate into less time for the patient,s skull to ...
(Date:7/10/2014)... today that Courtney Aldrich, Ph.D., will head the ... as editor-in-chief. With the first issue slated for ... meet a growing demand for a place to ... vision is to develop a journal focused on ... science that advances the field and lays the ...
Breaking Biology News(10 mins):Overfishing in the English Channel leaves fisherman scraping the bottom of the barrel 2Overfishing in the English Channel leaves fisherman scraping the bottom of the barrel 3A start-up at NJIT develops bleeding-control gel for brain surgery 2ACS Infectious Diseases: Unique chemistry journal names editor 2
... not only supplies key nutrients, it may also influence hormone ... a new study led by researchers at the University of ... diet in human evolution. The research is the ... phytoestrogens, and behavior in wild primates in this case, ...
... 19, 2012 Deciphering what causes the brain cell degeneration ... But a team led by scientists from The Scripps Research ... brain cells in a mouse model of Parkinson,s disease. The ... be useful in preventing the actual condition. The team, ...
... MD, MPH, has been named the winner of the $100,000 ... 6,500 online votes from people across the globe determined the ... sequencing of newborns, emerged as the winner after six weeks ... for creating this competition and I am delighted to win. ...
Cached Biology News:Estrogenic plants linked to altered hormones, possible behavior changes in monkeys 2Estrogenic plants linked to altered hormones, possible behavior changes in monkeys 3Scripps Research Institute team identifies a potential cause of Parkinson's disease 2Scripps Research Institute team identifies a potential cause of Parkinson's disease 3Research gets real - Public votes determine winner of $100,000 research prize 2
(Date:7/10/2014)... 10, 2014 /PRNewswire-iReach/ -- Tute Genomics, the ... announced an agreement with Lineagen, Inc., to ... NextStep Dx PLUS.  Lineagen, focused on ... disorders, currently offers FirstStep Dx PLUS, ... used by healthcare providers as a first-line ...
(Date:7/10/2014)... of Adelaide research may help in the fight against ... detect tiny quantities of explosives with the use of ... journal Sensors and Actuators B: Chemical , the ... detect explosives in concentrations as low as 6.3 ppm ... only a few minutes. , "Traditionally explosives detection has ...
(Date:7/10/2014)... fractional quantum Hall effect in bilayer graphene and shown ... by an electric field. , The fractional quantum ... thin sheets are exposed to large magnetic fields, is ... individual electrons behave as a single system. However, while ... many details of this collective behavior remain not well ...
(Date:7/10/2014)... at the University of Illinois at Urbana-Champaign provides ... interplay of spin and heat at the nanoscale, ... devices for data storage and information processing. ... spin-angular momentum. In a typical charge current, electrons, ... current," explained David Cahill, a professor of materials ...
Breaking Biology Technology:Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 3Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 4Detecting trace amounts of explosives with light 2Columbia researchers observe tunable quantum behavior in bilayer graphene 2Columbia researchers observe tunable quantum behavior in bilayer graphene 3University of Illinois study advances limits for ultrafast nano-devices 2
... 2011 Halozyme Therapeutics, Inc. (NASDAQ: ... products targeting the extracellular matrix for the ... financial results for the third quarter of 2011 and ... ) "The past few months highlight the ...
... 2011 BIOCOM, the trade group representing Southern California,s ... partnered to tell the biotechnology story from discovery through ... glimpse into the exciting and innovative world of medical ... to patients around the globe. "Tomorrow,s Health," a new ...
... 2011 Note: numbers in square brackets relate ... available for interview. Investment fund manager Porton Group ... a court battle with 3M over the multi-national company,s failure ... The High Court in London found 3M was "in material ...
Cached Biology Technology:Halozyme Therapeutics Reports Third Quarter 2011 Financial Results 2Halozyme Therapeutics Reports Third Quarter 2011 Financial Results 3Halozyme Therapeutics Reports Third Quarter 2011 Financial Results 4Halozyme Therapeutics Reports Third Quarter 2011 Financial Results 5Halozyme Therapeutics Reports Third Quarter 2011 Financial Results 6Halozyme Therapeutics Reports Third Quarter 2011 Financial Results 73M Forced to Pay for Breach of Obligations Over MRSA - High Court 23M Forced to Pay for Breach of Obligations Over MRSA - High Court 33M Forced to Pay for Breach of Obligations Over MRSA - High Court 4
quantitation of phosphatase activity, evaluation of hits and leads from HTS...
... ISO 9001:2000 Certified USDA Research Registered ... SOP's Training AALAS Certified Technicians ... Procedures GLP Documentation Upon Request Focus ... point for all your custom immunology service ...
Request Info...
Request Info...
Biology Products: