Navigation Links
Hormone acting as 'molecular glue' could boost plant immune systems
Date:10/6/2010

EAST LANSING, Mich. The discovery of a hormone acting like molecular glue could hold a key to bolstering plant immune systems and understanding how plants cope with environmental stress.

The study, which is featured in the Oct. 6 issue of Nature, reveals how the plant hormone jasmonate binds two proteins together an emerging new concept in hormone biology and protein chemistry. The study also identifies the receptor's crystal structure to provide the first molecular view of how plants ward off attacks by insects and pathogens.

In short, the work explains how a highly dynamic form of plant immunity is triggered, said Gregg Howe, biochemistry and molecular biology professor, who worked with fellow MSU professor Sheng Yang He on the study. The study is a collaboration between the MSU-Department of Energy Plant Research Laboratory and the University of Washington.

"In many respects, this receptor is novel in how it binds its target hormone to switch on gene expression," Howe said. "Jasmonate appears to act as molecular glue that sticks two proteins together, which sets off a chain of events leading to the immune response. Determining the structure of the receptor solves a big missing piece of the puzzle."

Earlier research conducted by Howe and He helped to unveil the mechanism of action of jasmonate, the last major plant hormone to have its signaling pathway decoded. When a plant is attacked, the jasmonate signal causes direct interaction between a family of JAZ repressor proteins and the F-box protein COI1, which works to eliminate JAZ proteins so the plant can mount a defense.

Reconstructing the molecular mechanism of jasmonate perception revealed a multicomponent signaling hub. Instead of working as a single protein, which is typical of most receptors, this new receptor is actually a co-receptor complex that consists of COI1, JAZ and a newly discovered third component, inositol pentakisphosphate, Howe said.

Now that researchers understand the structure, they can design new hormone derivatives or other small molecules that can trigger a desired response. Such compounds could help to increase agricultural productivity by aiding plants in resisting bugs and diseases, he added.

The Nature study shows that plants and animals use fundamentally different mechanisms to perceive this type of fatty acid-derived hormone. Humans have prostaglandin hormones, which are structurally similar to jasmonates and also play a role in immune responses. So this study may hold potential benefits for humans as well.

"Plants offer a rich opportunity to understand basic biological processes that are relevant to human health," Howe said. "The new structural insight into jasmonate perception could have practical applications in medicine, including the design of drugs that stick two proteins together."


'/>"/>

Contact: Layne Cameron
layne.cameron@ur.msu.edu
517-353-8819
Michigan State University
Source:Eurekalert

Related biology news :

1. UNH researcher helps identify key reproductive hormone in oldest vertebrate
2. Marriage and committed romance reduce stress-related hormone production
3. Cancer risk found for long-term hormone therapy
4. UBC researcher discovers ancient stress hormone in pre-historic fish
5. MSU sea lamprey research sheds light on how stress hormones evolved
6. Plant growth hormones: Antagonists cooperate
7. UM School of Medicine scientists find hormone influences sensitivity to sweetness
8. New study documents use of hormone progesterone in simple microscopic aquatic animals
9. Discovery: Yeast make plant hormone that speeds infection
10. Hormone spray improves male sensitivity
11. Hormone sensitivity of breast stem cells presents drug target
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2017)... and ITHACA, N.Y. , ... and Cornell University, a leader in dairy research, today ... bioinformatics designed to help reduce the chances that the ... the onset of this dairy project, Cornell University has ... for Sequencing the Food Supply Chain, a food safety ...
(Date:5/16/2017)... May 16, 2017   Bridge Patient Portal ... and MD EMR Systems , an electronic ... for GE, have established a partnership to build ... and the GE Centricity™ products, including Centricity Practice ... These new integrations will allow healthcare ...
(Date:4/18/2017)... 2017  Socionext Inc., a global expert in SoC-based imaging and ... the M820, which features the company,s hybrid codec technology. A demonstration ... Probe, Inc., will be showcased during the upcoming Medtec Japan at ... the Las Vegas Convention Center April 24-27. ... Click here for an ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... Florida (PRWEB) , ... October 11, 2017 , ... ... Drug Administration (FDA) has granted orphan drug designation to SBT-100, its novel anti-STAT3 ... for the treatment of osteosarcoma. SBT-100 is able to cross the cell membrane ...
(Date:10/10/2017)... ... October 10, 2017 , ... ... FirstHand program has won a US2020 STEM Mentoring Award. Representatives of the FirstHand ... Excellence in Volunteer Experience from US2020. , US2020’s mission is to change the ...
(Date:10/10/2017)... , Oct. 10, 2017 SomaGenics announced the ... NIH to develop RealSeq®-SC (Single Cell), expected to be ... small RNAs (including microRNAs) from single cells using NGS ... the need to accelerate development of approaches to analyze ... "New techniques for measuring levels of mRNAs ...
(Date:10/9/2017)... 2017  BioTech Holdings announced today identification and ... ProCell stem cell therapy prevents limb loss in ... demonstrated that treatment with ProCell resulted in more ... compared to standard bone marrow stem cell administration.  ... reduction of therapeutic effect.  ...
Breaking Biology Technology: