Navigation Links
Hormone acting as 'molecular glue' could boost plant immune systems
Date:10/6/2010

EAST LANSING, Mich. The discovery of a hormone acting like molecular glue could hold a key to bolstering plant immune systems and understanding how plants cope with environmental stress.

The study, which is featured in the Oct. 6 issue of Nature, reveals how the plant hormone jasmonate binds two proteins together an emerging new concept in hormone biology and protein chemistry. The study also identifies the receptor's crystal structure to provide the first molecular view of how plants ward off attacks by insects and pathogens.

In short, the work explains how a highly dynamic form of plant immunity is triggered, said Gregg Howe, biochemistry and molecular biology professor, who worked with fellow MSU professor Sheng Yang He on the study. The study is a collaboration between the MSU-Department of Energy Plant Research Laboratory and the University of Washington.

"In many respects, this receptor is novel in how it binds its target hormone to switch on gene expression," Howe said. "Jasmonate appears to act as molecular glue that sticks two proteins together, which sets off a chain of events leading to the immune response. Determining the structure of the receptor solves a big missing piece of the puzzle."

Earlier research conducted by Howe and He helped to unveil the mechanism of action of jasmonate, the last major plant hormone to have its signaling pathway decoded. When a plant is attacked, the jasmonate signal causes direct interaction between a family of JAZ repressor proteins and the F-box protein COI1, which works to eliminate JAZ proteins so the plant can mount a defense.

Reconstructing the molecular mechanism of jasmonate perception revealed a multicomponent signaling hub. Instead of working as a single protein, which is typical of most receptors, this new receptor is actually a co-receptor complex that consists of COI1, JAZ and a newly discovered third component, inositol pentakisphosphate, Howe said.

Now that researchers understand the structure, they can design new hormone derivatives or other small molecules that can trigger a desired response. Such compounds could help to increase agricultural productivity by aiding plants in resisting bugs and diseases, he added.

The Nature study shows that plants and animals use fundamentally different mechanisms to perceive this type of fatty acid-derived hormone. Humans have prostaglandin hormones, which are structurally similar to jasmonates and also play a role in immune responses. So this study may hold potential benefits for humans as well.

"Plants offer a rich opportunity to understand basic biological processes that are relevant to human health," Howe said. "The new structural insight into jasmonate perception could have practical applications in medicine, including the design of drugs that stick two proteins together."


'/>"/>

Contact: Layne Cameron
layne.cameron@ur.msu.edu
517-353-8819
Michigan State University
Source:Eurekalert

Related biology news :

1. UNH researcher helps identify key reproductive hormone in oldest vertebrate
2. Marriage and committed romance reduce stress-related hormone production
3. Cancer risk found for long-term hormone therapy
4. UBC researcher discovers ancient stress hormone in pre-historic fish
5. MSU sea lamprey research sheds light on how stress hormones evolved
6. Plant growth hormones: Antagonists cooperate
7. UM School of Medicine scientists find hormone influences sensitivity to sweetness
8. New study documents use of hormone progesterone in simple microscopic aquatic animals
9. Discovery: Yeast make plant hormone that speeds infection
10. Hormone spray improves male sensitivity
11. Hormone sensitivity of breast stem cells presents drug target
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/9/2017)... SAN FRANCISCO and MOUNTAIN VIEW, ... Zipongo , "Eating Well Made Simple," and 23andMe ... to help guide better food choices.  Zipongo can now ... only their food preferences, health goals and biometrics, but ... to certain food choices. Zipongo,s personalized food ...
(Date:3/2/2017)... , March 2, 2017 Summary ... understand Perrigo and its partnering interests and activities since 2010. ... Read ... Deals and Alliance since 2010 report provides an in-depth insight ... life sciences companies. On demand company reports are ...
(Date:3/1/2017)... 2017  Aware, Inc. (NASDAQ: AWRE), a leading supplier ... P. Moberg has resigned, effective March 3, 2017, ... Officer and Treasurer of Aware citing a desire to ... member of the Board of Directors of Aware. ... Officer and co-President, General Counsel has been named Chief ...
Breaking Biology News(10 mins):
(Date:3/28/2017)... (PRWEB) , ... March 28, 2017 , ... ... in the development of a new orally administered treatment for Alzheimer’s disease (AD), ... CEO John Didsbury states, “As we seek to uniquely treat the metabolic dysfunctions ...
(Date:3/27/2017)... -- Cousins Properties (NYSE: CUZ ) announced today ... signed a 10-year, approximately 125,000 square-foot lease at Corporate Center, ... the Westshore submarket of Tampa, FL. ... Corporate Center for their new location in Tampa ... executive officer of Cousins Properties. "Amgen is a cutting-edge global ...
(Date:3/27/2017)... 2017  Perthera,s Chief Bioinformatics Officer and research faculty ... , Ph.D., will be speaking at the American Medical ... March 27, 2017, she will be speaking on the ... Research and Care" (from 10:30 a.m. – 12:00 p.m. ... be a participant in the "Making Precision Oncology Data ...
(Date:3/27/2017)... , March 27, 2017  Trovagene, Inc. (NASDAQ: TROV), ... Chief Executive Officer, Bill Welch , will be ... 2017 at 9:00 AM EDT at the Essex House ... Welch, and Chief Scientific Officer, Mark Erlander , ... during the conference.   The presentation will be ...
Breaking Biology Technology: