Navigation Links
Hopkins team discovers sweet way to detect prediabetes
Date:7/8/2010

enter in collaboration with Christopher D. Saudek, M.D. and characterized as normal (36 samples), prediabetes (13 samples) and type 2 diabetes (53 samples) according to traditional tests that require patient fasting. Defined as normal hemoglobin A1c with impaired fasting glucose, prediabetes is an intermediate state of altered glucose metabolism with a heightened risk of developing type 2 diabetes and other associated complications.

Then, she measured and compared the amount of the enzyme protein within the red cells associated with the sugar molecule, O-GlcNAc.

"When I checked the enzyme levels and saw how dramatically different they were between the prediabetic cells and the controls, I thought I did something wrong," Park says. "I repeated the test five times until I could believe it myself."

Hart speculates that in diabetes and prediabetes, it's not a good thing for the increased amount of sugar to be attached to proteins, so the cell is responding by elevating the enzyme that gets rid of it.

"This is an example of how basic research is directly affecting a serious disease," Hart says, adding that his team's pilot studies encourage further investigation of a method that potentially could fill the void that currently exists for an easy, accurate routine test for prediabetes. "Only a much larger clinical trial will determine if, by measuring O-GlcNAcase, we can accurately diagnose prediabetes."


'/>"/>

Contact: Maryalice Yakutchik
myakutc1@jhmi.edu
443-287-2251
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2

Related biology news :

1. 2 Hopkins scientists awarded European honorary doctorates
2. Hopkins researchers put proteins right where they want them
3. Pancreatic Cancer Action Network-AACR Pathway to Leadership Grant awarded to Johns Hopkins Early Career investigator
4. Johns Hopkins scientists discover a controller of brain circuitry
5. Hopkins scientists ID 10 genes associated with a risk factor for sudden cardiac death
6. Johns Hopkins scientists pull proteins tail to curtail cancer
7. Johns Hopkins researchers detect sweet cacophony while listening to cellular cross-talk
8. Professor discovers way to slow the growth of malignant melanoma
9. York U autism-related study discovers how drug interferes with neuronal cell function
10. La Jolla Institute scientist leads team which discovers important new player in diabetes onset
11. McGill team discovers a piece of the puzzle for individualized cancer therapy via gene silencing
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/13/2015)... Jul. 13, 2015 NXT-ID, Inc. (NASDAQ: ... authentication company focused on the growing mobile commerce ... patent 62/188684 for BEHAVIORAL-DIRECTED AUTHENTIATION METHOD ... convenient and secure method to make payments.  With ... methods, introduced with its groundbreaking voice-direct payment patent ...
(Date:7/8/2015)... , July 8, 2015 Summary Pancreatic ... the fourth most fatal, with a mortality rate of ... prognosis of pancreatic cancer patients has highlighted a significant ... is not being met by the current market. ... of products with varying molecule types and mechanisms of ...
(Date:7/7/2015)... MOUNTAIN VIEW, Calif. , July 7, 2015 ... mobile biometrics market, Frost & Sullivan recognizes Credence ... & Sullivan Entrepreneurial Company of the Year ... product suite to aid in its mission of ... and under-recognized populations globally. As Credence ID was ...
Breaking Biology News(10 mins):NXT-ID Patents Behavior-Directed Payments 2NXT-ID Patents Behavior-Directed Payments 3NXT-ID Patents Behavior-Directed Payments 4Frontier Pharma: Pancreatic Cancer - Identifying and Commercializing First-in-Class Innovation 2Frontier Pharma: Pancreatic Cancer - Identifying and Commercializing First-in-Class Innovation 3Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 2Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 3Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 4Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 5
... scleroderma has slowed Tracy Zinn but it has not stopped ... accommodating employer, Zinn is now in her 13th year as ... But, many with the incapacitating disease are not as fortunate. ... people with systemic scleroderma, also known as systemic sclerosis, is ...
... 2011 DigitalPersona, Inc. , a global provider ... Pizza Hut™ franchisee Rage, Inc. has rolled out ... locations throughout the east coast in South Carolina, North ... By deploying fingerprint biometrics as a part of their ...
... 2001--Eating nuts every day could help control Type 2 ... from St. Michael,s Hospital and the University of Toronto. ... Diabetes Care , a team of researchers led ... Nutritional Sciences; St. Michael,s Hospital Risk Factor Modification Centre) ...
Cached Biology News:Scleroderma study identifies roadblocks to employment 2Scleroderma study identifies roadblocks to employment 3Pizza Hut Franchisee Saves Dough by Slicing Payroll Fraud and Leavening Store Revenue with Digital Persona Fingerprint Biometrics 2A 'nutty' solution to type 2 diabetes management 2
(Date:7/29/2015)... PARIS , July 30, 2015 ... leader, reports results for the second quarter of ... the group,s results and its performance in different ... transcript:  http://www.eurobusinessmedia.com/ceo-direct/sanofi/sanofi-h1-2015-results-interview-with-ceo-olivier-brandicourt?utm_source=ceo-direct&utm_medium=wire ... - Q2 results - Performance drivers ...
(Date:7/29/2015)... Japan (Q2 2015: +14% CER / 20% of sales) ... in China , as well as solid contributions from Korea, ... Europe / Middle East / ... in Germany , Turkey and the ... 49% of sales) grew 11%, excluding U.S. HPV sales, on demand across all ...
(Date:7/29/2015)... (PRWEB) , ... July 29, 2015 , ... ... manufacturer and supplier, announces the launch of their 2nd generation cell therapy POD® ... current miniPOD CT, but it also represents a new POD® design. , ...
(Date:7/29/2015)... NEW YORK , July 29, 2015 /PRNewswire/ ... neuropathology testing, announces increased partnerships with VA and ... offers Epidermal Nerve Fiber Density (ENFD) and Sweat ... of small fiber neuropathy ( https://therapath.com/skin ). ... Epidermal Nerve Fiber Density (ENFD) on punch skin ...
Breaking Biology Technology:QIAGEN Reports Results for Second Quarter and First Half of 2015 2QIAGEN Reports Results for Second Quarter and First Half of 2015 3QIAGEN Reports Results for Second Quarter and First Half of 2015 4QIAGEN Reports Results for Second Quarter and First Half of 2015 5QIAGEN Reports Results for Second Quarter and First Half of 2015 6QIAGEN Reports Results for Second Quarter and First Half of 2015 7QIAGEN Reports Results for Second Quarter and First Half of 2015 8QIAGEN Reports Results for Second Quarter and First Half of 2015 9QIAGEN Reports Results for Second Quarter and First Half of 2015 10G-CON Manufacturing Launches Their 2nd Generation Cell Therapy Cleanroom POD® 2G-CON Manufacturing Launches Their 2nd Generation Cell Therapy Cleanroom POD® 3Neuropathology services for VA and Military health systems 2
... Corporation (OTC Bulletin Board: MFLU) announced today that the ... Monday, November 2, 2009, after the closing of the ... ) , Michael C. Ferrara, President and Chief ... Finance and Chief Accounting Officer, will host a conference ...
... -- In response to requests from clients, Schulman ... , The Schulman Canadian Board,s first official meeting is ... are conducted in both the U.S. and Canada, Canadian and ... to maintain consistency. , "Our clients have asked us to ...
... The Board of Directors of Biomoda, Inc. (OTC Bulletin ... cancer detection medical diagnostics company, has elected Maria Zannes ... the Biomoda Board May 1, 2008. , "Maria,s extraordinary ... perfect individual to safeguard our commitment to good corporate ...
Cached Biology Technology:Microfluidics International Corporation to Report Third Quarter 2009 Financial Results on November 2, 2009 2Microfluidics International Corporation to Report Third Quarter 2009 Financial Results on November 2, 2009 3Schulman Associates IRB Establishes an Institutional Review Board in Canada 2Biomoda Board of Directors Names New Corporate Secretary 2
Kit contains: Bio-Rad Amplification Reagent, 2x Amplification Diluent, Streptavidin-HRP, Blocking Reagent, and Phosphate Buffered Saline....
These macrocarriers are for the biolistic PDS-1000 He and Hepta systems. Supplied as 500 macrocarriers....
Intestinal Epithelium Differentiation Environment...
Hepatocyte Differentiation Environment...
Biology Products: