Navigation Links
Hopkins team discovers sweet way to detect prediabetes
Date:7/8/2010

Having discovered a dramatic increase of an easy-to-detect enzyme in the red blood cells of people with diabetes and prediabetes, Johns Hopkins scientists say the discovery could lead to a simple, routine test for detecting the subtle onset of the disease, before symptoms or complications occur and in time to reverse its course.

Pilot studies, published online April 22 in Diabetes, show the enzyme O-GlcNAcase is up to two to three times higher in people with diabetes and prediabetes than in those with no disease: "That's a big difference, especially in an enzyme that's as tightly regulated as this one is," says Gerald Hart, Ph.D., the DeLamar Professor and director of biological chemistry at the Johns Hopkins School of Medicine.

Building on their previous research, which showed how an abundant but difficult-to-detect sugar switch known as O-GlcNAc (pronounced oh-GLICK-nack) responded to nutrients and stress, the Hopkins team knew this small molecule was elevated in the red cells of patients with diabetes. "The question was whether the elevation happened in the earliest stages of diabetes and therefore might have value as a diagnostic tool," Hart said.

To find out, Kyoungsook Park, a graduate student of biological chemistry working in Hart's lab, focused on levels of O-GlcNAcase, an enzyme that removes O-GlcNAc in red cells. O-GlcNAc modifies many of the cell's proteins to control their functions in response to nutrients and stress. Nutrients, such as glucose and lipids, increase the extent of O-GlcNAc modification of proteins affecting their activities. When the extent of O-GlcNAc attached to proteins becomes too high, as occurs in diabetes, it is harmful to the cell.

First, Park purified human red blood cells by depleting them of their main constituent, hemoglobin. The samples had been collected by two sources the National Institute of Diabetes, Digestive and Kidney Diseases, or NIDDK, and Johns Hopkins Diabetes C
'/>"/>

Contact: Maryalice Yakutchik
myakutc1@jhmi.edu
443-287-2251
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2

Related biology news :

1. 2 Hopkins scientists awarded European honorary doctorates
2. Hopkins researchers put proteins right where they want them
3. Pancreatic Cancer Action Network-AACR Pathway to Leadership Grant awarded to Johns Hopkins Early Career investigator
4. Johns Hopkins scientists discover a controller of brain circuitry
5. Hopkins scientists ID 10 genes associated with a risk factor for sudden cardiac death
6. Johns Hopkins scientists pull proteins tail to curtail cancer
7. Johns Hopkins researchers detect sweet cacophony while listening to cellular cross-talk
8. Professor discovers way to slow the growth of malignant melanoma
9. York U autism-related study discovers how drug interferes with neuronal cell function
10. La Jolla Institute scientist leads team which discovers important new player in diabetes onset
11. McGill team discovers a piece of the puzzle for individualized cancer therapy via gene silencing
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2015)... 2015 Research and ... the "Body-Worn Temperature Sensors Market - Global ... 2014 - 2020" report to their offering. ... the global body-worn temperature sensors market. The global ... the basis of types, care setting, patient demographic, ...
(Date:6/17/2015)... , Deutschland und GERMANTOWN, Maryland ... Investigator ®   Produktlinie mit DNA-Tests ... QIAGEN N.V. (NASDAQ: QGEN ; Frankfurt Prime Standard: ... neue STR-Testkits der Produktlinie Investigator ... in den Markt eingeführt. Die neuen Kits zur Erstellung ...
(Date:6/16/2015)... NEW YORK , June 16, 2015  With ... the world, security remains a top concern. The recent ... confirms the need for strong authentication within government ... HYPR Token, a biometric one-time password (OTP) authenticator, has ... Processing Standards (FIPS) 140-2 Level 3 validation for tamper ...
Breaking Biology News(10 mins):Body-Worn Temperature Sensors Market - Global Industry Analysis 2QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 2QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 3QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 4QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 5QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 6Government Ready Biometric Security Approaching as HYPR Corp. Files FIPS 140-2 Level 3 Validation for Its Proprietary Biometric Token 2Government Ready Biometric Security Approaching as HYPR Corp. Files FIPS 140-2 Level 3 Validation for Its Proprietary Biometric Token 3
... Millions of patients suffering from liver,damage (cirrhosis) and ... Edinburgh and Southampton which may lead to new,life-saving ... cirrhosis,and a patient's only hope of survival is ... the University's Centre for Inflammation,Research, in collaboration with ...
... of Oregon have,discovered a form of blue-green algae ... light for photosynthesis,according to an article published in ... National Academy of Sciences (PNAS).,"This new strain of ... live,on its own," says UO biology professor Michelle ...
... work, scientists have now found that changes in a single ... fish living in the wild. , The surprising results, announced ... new data to long-standing debates about how evolution occurs in ... how new animal types evolve in nature," said molecular geneticist ...
Cached Biology News:Research Gives Hope For Liver Damage 2Scientists discover unique microbe in California's largest lake 2Scientists discover unique microbe in California's largest lake 3Scientists discover unique microbe in California's largest lake 4Scientists discover unique microbe in California's largest lake 5Octopuses occasionally stroll around on two arms, UC Berkeley biologists report 2Octopuses occasionally stroll around on two arms, UC Berkeley biologists report 3Octopuses occasionally stroll around on two arms, UC Berkeley biologists report 4Octopuses occasionally stroll around on two arms, UC Berkeley biologists report 5
(Date:7/1/2015)... and PARIS , July 1, ... Genective, key developer of biotech crops, today announce ... new generations of insect control traits. ... counter the realities of advancing insect resistance. We ... unique insect control technology with Genective,s capability in ...
(Date:7/1/2015)... ALTO, Calif. , July 1, 2015 /PRNewswire/ ... focused on the development of groundbreaking drugs to ... (ALS), announced today that Robert G. Miller ... Center at Sutter Health,s California Pacific Medical Center ... The ALS Association for $1.5 million to help ...
(Date:7/1/2015)... , July 1, 2015 ... technology will ... s evidence-based clinical s olutions suite   ... technical and medical information products and services, announced today the ... clinical decision support (CDS) technology company. InferMed,s Arezzo ...
(Date:6/30/2015)... R-Japan Co.,Ltd. obtained the license of cell processing ... from the Ministry of Health, Labour and Welfare Kinki Bureau ... The fact that R- Japan received ... Pharmaceuticals and Medical Devices Agency (PMDA) on May 18, 2015 ... stem cell manufacturing service to medical institutions. As of November ...
Breaking Biology Technology:AgBiome and Genective collaborate to create novel insect-resistant crops 2Investigator to Receive $1.5 Million Grant from the ALS Association to Help Fund Confirmatory Phase 2 Study of Neuraltus Pharmaceuticals' NP001 2Investigator to Receive $1.5 Million Grant from the ALS Association to Help Fund Confirmatory Phase 2 Study of Neuraltus Pharmaceuticals' NP001 3Investigator to Receive $1.5 Million Grant from the ALS Association to Help Fund Confirmatory Phase 2 Study of Neuraltus Pharmaceuticals' NP001 4Elsevier Acquires InferMed, Provider of Clinical Decision Support Technology 2Elsevier Acquires InferMed, Provider of Clinical Decision Support Technology 3Elsevier Acquires InferMed, Provider of Clinical Decision Support Technology 4R-Japan Obtained Autologous Stem Cell Manufacturing License from the Ministry of Health, Labour and Welfare 2
... Group today released its syndicated report TreatmentTrends ... the fourth annual survey of U.S. Dermatologists (n=150). The ... April, highlights shifting trends in the management of psoriasis and ... mild, moderate, and severe patients with an emphasis on the ...
... GAITHERSBURG, Md., May 28 GenVec, Inc. (Nasdaq: ... purchase agreement with a single institutional investor for the sale of ... shares of its common stock. The shares of common stock ... of common stock and a warrant to purchase one share of ...
... researchers at the University of Illinois has demonstrated that, ... superconducting electrons in an ultrathin superconducting wire is able ... a higher electrical current to one with a notably ... macroscopic quantum tunneling. , Physics professors Alexey Bezryadin and ...
Cached Biology Technology:Raptiva Withdrawal Offers Upside for Enbrel and Humira According to Latest BioTrends Survey of U.S. Dermatologists 2GenVec Announces Registered Offering of $6 Million in Common Stock and Warrants 2GenVec Announces Registered Offering of $6 Million in Common Stock and Warrants 3Evidence of macroscopic quantum tunneling detected in nanowires 2