Navigation Links
Hopes that new substance will induce cancer cell suicide
Date:9/18/2012

The p53 gene plays a key role in the prevention of cancer, by blocking cell growth and triggering programmed cell death or apoptosis. If, however, p53 has mutated and become defective, the cancer cells can acquire the ability to evade apoptosis and become more resistant to therapy. Researchers at Karolinska Institutet and Karolinska University Hospital in Sweden have now obtained results from the first tests using a new substance that can restore the function of defective p53 and activate apoptosis in cancer cells.

The substance is known as APR-246 and has now been tested on humans in a phase I/II study, which was conducted on 22 patients with advanced blood or prostate cancer. Some of the patients came from the Haematology Centre at the Karolinska University Hospital in, Stockholm, where the study's lead investigator, consultant Dr Sren Lehmann is based. The remainder of the patients were from other clinics in Gothenburg, Lund, Uppsala and rebro.

The patients received daily infusions of APR-246 for four days. When the researchers analyzed the cancer cells taken before and after treatment, they saw indications that the p53 gene had been activated to varying degrees, and that this had triggered the suicide program in the cancer cells. Ten patients could be evaluated as regards the development of their cancer, and in two of them there were signs of tumour regression.

However, the study was actually not designed to test the clinical effects but to ascertain how well the substance was tolerated by the body. With the main adverse reactions confined to temporary tiredness, nausea, headache and confusion, their results would suggest that the substance is well tolerated.

"The side-effects were totally different to those produced by conventional chemotherapy, which bodes well for designing combination therapies," says Dr Lehmann. "And it's in precisely this kind of combination that we think the substance has the greatest potential. I
'/>"/>

Contact: Press Office
pressinfo@ki.se
46-852-486-077
Karolinska Institutet
Source:Eurekalert

Page: 1 2

Related biology news :

1. On the safe side: Contact-free analysis of chemical substances
2. Using cell phones to detect harmful airborne substances
3. Weight gain induced by high-fat diet increases active-period sleep and sleep fragmentation
4. Light-induced delivery of nitric oxide eradicates drug-resistant bacteria
5. Eliza Corporation and BlueCross BlueShield of South Carolina Drive Awareness and Healthier Behavior to Increase Colorectal Cancer Screenings by 45 Percent
6. Mushroom-derived compound lengthens survival in dogs with cancer, Penn Vet study finds
7. Researchers reveal a chemo-resistant cancer stem cell as cancers Achilles heel
8. Swim training plus healthy diet factor in cancer fight: New study
9. UNC Lineberger scientists lead definition of key lung cancer genome
10. New potential targets discovered for treating squamous cell lung cancers
11. The CNIO welcomes the new academic year with a spotlight on cancer genetics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... Researchers at UC Davis have made some surprising ... infection. Studying simian immunodeficiency virus (SIV), the team ... Paneth cells are early responders to viral invasion ... producing a cytokine called interleukin-1 beta (IL-1β). ... IL-1β causes breakdown of the gut epithelium that ...
(Date:8/29/2014)... recently, little has been known about what genetic changes ... of scientists, one of whom is a University of ... that genes controlling the development of the brain and ... The study was published Aug. 28 in Science ... is online at http://www.sciencemag.org/ ., The domestication of ...
(Date:8/29/2014)... over the last 120,000 years may have influenced ... researchers led by City College of New York ... metric called "phylogeographic endemism." , It quantifies the ... is restricted in geographical space. , Dr. Carnaval, ... researchers from institutions in Brazil, Australia and the ...
Breaking Biology News(10 mins):The early cost of HIV 2New research reveals how wild rabbits were genetically transformed into tame rabbits 2New research reveals how wild rabbits were genetically transformed into tame rabbits 3CCNY team defines new biodiversity metric 2
... researchers may have found a way to deliver chemotherapeutic ... healthy body cells. If successful, the invention of ... cancer cells and alleviate the harmful side effects that ... Marek Romanowski, an associate professor of biomedical engineering in ...
... commercial and recreational fish species, may be more vulnerable ... a new study published by scientists from NOAA, The ... Marine and Atmospheric Science. An expanding zone ... the Atlantic Ocean is encroaching upon these species, preferred ...
... by a team of researchers in New York and ... belief that the pterygotid eurypterids ("sea scorpions") were high-level ... the seas from about 470 to 370 million years ... and, arguably, scariest-looking arthropods known to have evolved on ...
Cached Biology News:Invention could improve cancer drug delivery, lessen harmful effects of chemotherapy 2Invention could improve cancer drug delivery, lessen harmful effects of chemotherapy 3Invention could improve cancer drug delivery, lessen harmful effects of chemotherapy 4Growing hypoxic zones reduce habitat for billfish and tuna 2Pterygotid sea scorpions: No longer terror of the ancient seas? 2
(Date:8/29/2014)... circuits are based on electrons, but one of the ... circuits, i.e. circuits based on light (photons) instead of ... create a stream of single photons and control their ... of attempts to achieve this control, but now scientists ... a steady stream of photons emitted one at a ...
(Date:8/29/2014)... NY (PRWEB) August 29, 2014 Local ... Hills Veterinary Hospital are seeking candidates to participate in ... with osteoarthritis. The ultimate goal of this study ... stem cells into one or two arthritically affected joints ... joints. , Candidates for the current investigational study ...
(Date:8/28/2014)... (PRWEB) August 28, 2014 SPIE Fellow ... Physics and Optical Science and Director of the Center ... North Carolina at Charlotte, and co-founder and Chairman of ... serve as the 2015 Vice President of SPIE, the ... President Philip Stahl announced recent election results at the ...
(Date:8/28/2014)... converters are important devices in spintronics, an electronic ... of electrons but also on their spin and ... of electric into magnetic signals and vice versa. ... from the Institute of Physics at Johannes Gutenberg ... UK, Prague, and Japan, has for the first ...
Breaking Biology Technology:Breakthrough in light sources for new quantum technology 2Burnt Hills Veterinary Hospital Seeks Candidates for an Investigational Study of Stem Cells for Dogs with Arthritis 2Glenn Boreman, UNC Professor and Plasmonics Co-Founder, Elected to SPIE Presidential Chain 2A new, tunable device for spintronics 2A new, tunable device for spintronics 3
... 2011 "ALBERT EINSTEIN" World Award of Science to Professor ... Professor University of Toronto, Canada. The members ... the winner of the 2011 "ALBERT EINSTEIN" World Award ... of nanochemistry that have helped to define and establish ...
... DIEGO, Sept. 6, 2011 Anadys Pharmaceuticals, Inc. (Nasdaq: ... the Company,s presentation at the Stifel Nicolaus Healthcare Conference to ... PDT).  The conference is being held at the Four Seasons ... Officer of Anadys, will provide an overview of Anadys and ...
... French genome engineering specialist, will present at the UBS Global Life ... at the MidCap Event in Paris on September 22 & 23, ... and the development strategy of the Cellectis group at the UBS ... on Tuesday, September 20, 2011 at 11:30 am ET. ...
Cached Biology Technology:2011 Awards of World Cultural Council 22011 Awards of World Cultural Council 32011 Awards of World Cultural Council 42011 Awards of World Cultural Council 5Anadys Pharmaceuticals Updates Its Presentation Date at the Stifel Nicolaus Healthcare Conference 2
... 120 V, is used for agitation and mixing ... staining and destaining of gels and blots, and ... (8-40 rpm) and can handle a maximum load ... two 29 x 21 cm platforms covered with ...
Mouse monoclonal antibody to DCAMKL2 - doublecortin and CaM kinase-like 2...
...
...
Biology Products: