Navigation Links
Hopes for reversing age-associated effects in MS patients
Date:1/6/2012

New research highlights the possibility of reversing ageing in the central nervous system for multiple sclerosis (MS) patients. The study is published today, 06 January, in the journal Cell Stem Cell.

As we get older, our bodies' ability to regenerate decreases. This is not only true for our skin (which is evident in the wrinkles that develop as we age) but also true for other tissues in the body, including the regenerative processes in the brain. For diseases which often span several decades and are affected by regenerative processes, such as multiple sclerosis, this can have massive implications.

In multiple sclerosis, the insulating layers that protect nerve fibres in the brain, known as myelin sheaths, become damaged. The loss of myelin in the brain prevents nerve fibres from sending signals properly and will eventually lead to the loss of the nerve fibre itself. However, early in the disease, a regenerative process, or remyelination, occurs and the myelin sheaths are restored. Unfortunately, as people with MS age, remyelination decreases significantly, resulting in more nerve fibres being permanently lost.

However, a new study in mice shows that the age-associated decline in the regeneration of the nerve's myelin sheath, or remyelination, is reversible. The proof of principle study demonstrates that when old mice are exposed to the inflammatory cells (called monocytes) from young mice, the ageing remyelination process can be reversed.

Professor Robin Franklin, Director of the MS Society's Cambridge Centre for Myelin Repair at the University of Cambridge, said: "What we have shown in our study, carried out in collaboration with Dr Amy Wagers and colleagues at Harvard University, is that the age-associated decline in remyelination is reversible. We found that remyelination in old adult mice can be made to work as efficiently as it does in young adult mice.

"For individuals with MS, this means
'/>"/>

Contact: Genevieve Maul
gm349@admin.cam.ac.uk
01-223-332-300
University of Cambridge
Source:Eurekalert

Page: 1 2

Related biology news :

1. Purdue startup hopes to change the way we test cancer drugs
2. Team hopes to cut years off development time of new antibiotics
3. Reversing aging
4. New breathing therapy reduces panic and anxiety by reversing hyperventilation
5. Study reveals new possibility of reversing damage caused by MS
6. Preventing or reversing inflammation after heart attack, stroke may require 2-pronged approach
7. Reversing ecology reveals ancient environments
8. Scientists identify age-associated defects in schizophrenia
9. Wayne State study finds soybean compounds enhances effects of cancer radiotherapy
10. Researchers assess effects of a world awash in nitrogen
11. Submarine springs offer preview of ocean acidification effects on coral reefs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/10/2014)... DUBLIN , Dec. 08, 2014 Research ... announced the addition of the "Biometrics Market ... http://photos.prnewswire.com/prnh/20130307/600769 ... for projects such as rural banking and upgradation ... major trends witnessed in the market. Besides the ...
(Date:12/4/2014)... GARDENS, Fla. , Dec. 3, 2014 /PRNewswire/ ... solutions, today announced that its DigitalPersona ® ... fingerprint readers have been deployed throughout First Bank ... , South Carolina and ... in Southern Pines, North Carolina ...
(Date:11/21/2014)... , Nov. 19, 2014  Earlier this year ... New York College, and one of the most prolific ... signals that are transmitted from Smartphones to third party ... Smartphones and has one of the earliest known patents ... its usage in the military, child care, elder care ...
Breaking Biology News(10 mins):Biometrics Market in Japan 2014-2018: Key Vendors are DDS, Fujitsu, Hitachi and NEC 2First Bank Partners with Crossmatch to Increase Log In Security 2First Bank Partners with Crossmatch to Increase Log In Security 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 2Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 4
... Athens, Ga. Companion animals that have a long-term need ... top-selling antiplatelet drug marketed to humans: clopidogrel, commonly known ... Georgia College of Veterinary Medicine have found ,that clopidogrel may ... long-term anticoagulant therapy. In addition, it may offer a ...
... Associate Professor at The City College of New York (CCNY), have ... water so that it can be scooped up like the fat ... soup. The agent could potentially be used to recover oil lost ... Professor John said. In the laboratory, Professor John and colleagues ...
... in cities, disposing of garbage and recycling anything that ... city and cell, health problems can arise when the ... of Michigan cell biologist Haoxing Xu and colleagues reveals ... recycling center, the lysosome, functions. These insights, which may ...
Cached Biology News:Plavix may be treatment for dogs at risk of thromboembolic disease 2Opening the gate to the cell's recycling center 2
(Date:12/22/2014)... ITRA Global, one of the largest organizations dedicated ... has further expanded its global reach with the affiliation ... Australia, reports Mylinda Vick, CCIM, Chairman of the ITRA ... ACORPP (Australian Corporate Property and Projects) , is a ... to a wide range of clients in the private ...
(Date:12/19/2014)... Charm Sciences is pleased to announce that its ... M1 in raw commingled milk is the first lateral ... peer reviewed report of the validation by Technology and ... Fisheries Research (ILVO-T&V) has been published by the Taylor ... toxic aflatoxin and a known carcinogen, can be passed ...
(Date:12/19/2014)... -- Roche (SIX: RO, ROG; OTCQX: RHHBY) announced today ... privately held company based in Redwood ... big data platform for centralized management and processing ... on-market Genomic Management Solution, Bina-GMS 1 , empowers ... and scalable analyses to maximize the value of ...
(Date:12/19/2014)... DUBLIN , Dec. 19, 2014 Research ... announced the addition of the "Technology Innovations ... their offering. http://photos.prnewswire.com/prnh/20130307/600769 ... Innovations in Smart Fabrics" offers a detailed assessment ... Key Findings: 1. ...
Breaking Biology Technology:ITRA Global Continues International Expansion in Perth and Brisbane, Australia 2Charm Sciences Achieves Independent Validation of First 15 Minute Quantitative Screening Method for Aflatoxin M1 2Roche acquires Bina Technologies and enters the genomic informatics market 2Roche acquires Bina Technologies and enters the genomic informatics market 3Technology Innovations in Smart Fabrics (Technical Insights) 2
... New Service Helps Customers to Treat More Patients, ... ARAY ), a global leader in the ... begin offering a treatment planning,service to new and ... centers to access a dedicated team of remote ...
... Quintiles,Transnational Corp. today announced the completion of ... company,s continued,growth under the leadership of founder and ... management team. Gillings and global private,investment firms Bain ... in Quintiles, with 3i also becoming a significant ...
... Ind., Jan. 23 Zimmer Holdings, Inc.,(NYSE: ZMH ... announced,today it will be participating in the Wachovia Securities ... 10:15 a.m. Eastern Time., A live webcast of ... at http://investor.zimmer.com . The webcast will,be archived for ...
Cached Biology Technology:Accuray Announces New Treatment Planning Service Offering 2Accuray Announces New Treatment Planning Service Offering 3Accuray Announces New Treatment Planning Service Offering 4Quintiles Completes Previously Announced New Investor Partnership, Co-Led by Founder, Chairman and CEO Dennis Gillings, Bain Capital, TPG and 3i 2Quintiles Completes Previously Announced New Investor Partnership, Co-Led by Founder, Chairman and CEO Dennis Gillings, Bain Capital, TPG and 3i 3