Navigation Links
Honey bee gene targeting offers system to understand food-related behavior
Date:7/25/2013

On July 25th JoVE, the Journal of Visualized Experiments will publish a new technique that will help scientists better understand the genes that govern food-related behavior in honey bees. The impact of this study could take scientists one-step closer toward understanding and perhaps changing undesirable food-related behavior in humans via gene control.

"Our technique has already helped to unravel [the] complex gene networks behind biological processes and behavior, such as gustatory perception," said Dr. Ying Wang of Arizona State University. She and a team of scientists are behind the experiment, titled RNAi-mediated Double Gene Knockdown and Gustatory Perception Measurement in Honey Bees. "Honey bees are much less complex than mammals and humans, but [we] share many major genes," said Wang, "therefore, honey bees have become an emerging system for us to understand food related behavior in humans."

In Wang's previous study, she found that carbohydrate metabolism and insulin pathway genes were involved in honey bee gustatory perception. Her new article introduces two strategies for targeting and simultaneously down-regulating multiple genes in honey bees via RNA interference. This allows for further research in examining the role of insulin metabolism in gustatory perception. The team believes it will be important to understanding how insulin pathways play a role in food-related behavior.

Wang's multiple gene knockdown method is a first in entomology, and it overcomes the many shortfalls associated with typical single-gene targeting methods. A common problem associated with single gene suppression is that it is not sufficient to show the interrelationship of a gene network.

In the article published today, Wang's team has also provided a technique to measure the resulting changes in honey bee behavior, and this has led them to interesting observations. "Gustatory perception is a behavioral predictor for honey bee social behavior," said Wang. A honey bee's sensitivity to sugar predicts the food-choices and timing of foraging.

Wang's experiment opens the door for researchers to build upon her lab's techniques. "We believe our double knockdown approach will be more recognized and shared in the field when it is published in the video journal JoVE," said Wang.

With any luck, the impact will result in more than just high-tech pest control. It could instead provide insight into human insulin pathways, potentially giving us an opportunity to learn how to control human dietary behavior.


'/>"/>

Contact: Rachel Greene
rachel.greene@jove.com
617-250-8451
The Journal of Visualized Experiments
Source:Eurekalert

Related biology news :

1. Insecticide causes changes in honeybee genes, research finds
2. Wild pollinators increase crop fruit set regardless of honey bees
3. Researchers identify new components of the epigenetic code for honey bee development
4. Honeybees harbor antibiotic-resistance genes
5. Highly contagious honey bee virus transmitted by mites
6. Commonly used pesticide turns honey bees into picky eaters
7. Selenium impacts honey bee behavior and survival
8. Can behavior be controlled by genes? The case of honeybee work assignments
9. U of M researchers develop model for better testing, targeting of MPNST
10. Therapies for ALL and AML targeting MER receptor hold promise of more effect with less side-effect
11. Signalling pathways meeting targeting the HER/EGFR family: Focus on breast, lung and colorectal cancers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/7/2016)... -- Syngrafii Inc. and San Antonio Credit Union (SACU) ... Syngrafii,s patented LongPen™ eSignature "Wet" solution into SACU,s ... in greater convenience for SACU members and operational ... document workflow and compliance requirements. Logo ... Highlights: ...
(Date:6/2/2016)... 2016 Perimeter Surveillance & Detection ... Physical Infrastructure, Support & Other Service  The ... offers comprehensive analysis of the global Border Security ... revenues of $17.98 billion in 2016. Now: ... leader in software and hardware technologies for advanced video ...
(Date:5/16/2016)... YORK , May 16, 2016   EyeLock ... solutions, today announced the opening of an IoT Center ... to strengthen and expand the development of embedded iris ... an unprecedented level of convenience and security with unmatched ... authenticate one,s identity aside from DNA. EyeLock,s platform uses ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... June 23, 2016 , ... UAS LifeSciences, one of the ... brand, UP4™ Probiotics, into Target stores nationwide. The company, which has been manufacturing ... to its list of well-respected retailers. This list includes such fine stores as ...
(Date:6/23/2016)... Houston Methodist Willowbrook Hospital has signed ... to serve as their official health care provider. ... will provide sponsorship support, athletic training services, and ... volunteers, athletes and families. "We are ... and to bring Houston Methodist quality services and ...
(Date:6/23/2016)... 23, 2016   EpiBiome , a precision microbiome ... in debt financing from Silicon Valley Bank (SVB). The ... to advance its drug development efforts, as well as ... "SVB has been an incredible strategic partner to ... traditional bank would provide," said Dr. Aeron Tynes ...
(Date:6/23/2016)... June 23, 2016 Apellis Pharmaceuticals, Inc. ... clinical trials of its complement C3 inhibitor, APL-2. ... multiple ascending dose studies designed to assess the ... subcutaneous injection in healthy adult volunteers. ... as a single dose (ranging from 45 to ...
Breaking Biology Technology: