Navigation Links
Hitting target in cancer fight now easier with new nanoparticle platform, UCLA scientists say
Date:5/4/2011

The ability to use nanoparticles to deliver payloads of cancer-fighting drugs to tumors in the body could herald a fundamental change in chemotherapy treatment. But scientists are still at a relatively early stage in the implementation of this technology.

Although developing nanoparticles that work as "magic bullets" selectively targeting tumors while sparing normal, healthy tissues is still the goal, the reality is that most of these nanocarriers are removed through the liver and spleen before ever reaching their intended target. And many of the encapsulated drugs can be lost while the carriers circulate in the blood or degraded on the way to tumors.

In a study recently published in the journal ACS Nano, UCLA scientists report that by using engineered mesoporous silica nanoparticles (MSNPs) as delivery vehicles, they were able to achieve significant increases in the percentage of drug-carrying nanoparticles that reach and are retained at tumor sites.

The MSNP platform allows for the introduction of multiple and customized design features that can help optimize the delivery of chemotherapeutic drugs to a variety of cancer types, said the researchers, led by Dr. Andre Nel, a professor of medicine, pediatrics and public health and chief of the nanomedicine division in the UCLA Department of Medicine, and Jeffrey Zink, a professor in the UCLA Department of Chemistry and Biochemistry. Nel and Zink are also members of the California NanoSystems Institute at UCLA.

A key challenge in enhancing drug delivery has been improving nanocarriers' access to tumors by capitalizing on features like the leakiness of abnormal tumor blood vessels, which allows nanoparticles to slip through and be retained at tumor sites. To achieve that, particles must be designed to be the ideal size, to remain in the blood stream long enough by temporarily evading the liver and spleen, and to stably bind the drug.

The dynamic design
'/>"/>

Contact: Jennifer Marcus
jmarcus@cnsi.ucla.edu
310-267-4839
University of California - Los Angeles
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study shows hunger hitting closer to home
2. Chances of hurricane hitting Texas discussed at UH conference
3. How your body clock avoids hitting the snooze button
4. Why the swamp sparrow is hitting the high notes
5. MIT: Removable cloak for nanoparticles helps them target tumors
6. System in brain -- target of class of diabetes drugs -- linked to weight gain
7. La Jolla Institute identifies new therapeutic target for asthma, COPD and other lung disorders
8. Lesser-known Escherichia coli types targeted in food safety research
9. Target for lung cancer chemoprevention identified
10. Short rotation energy crops could help meet UKs renewable energy targets
11. Study identifies promising target for AIDS vaccine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/6/2015)... , August 6, 2015 ... (SMI) shows the world,s first Eye Tracking Integration ... Moverio BT-200 see-through head mounted display and on SMI,s ... quality and efficiency is brought to personalized visualization and ... first time, professionals and researchers can integrate gaze, and ...
(Date:8/4/2015)... , Aug. 04, 2015 ... http://www.researchandmarkets.com/research/nvh7k2/digital_forensics ) has announced the addition of ... (Hardware, Software, and Service), Sub-Segment (Computer Forensics, ... Forensics), Tool Types, Service, Vertical and Region ... to their offering. By Component ...
(Date:7/31/2015)... de 2015 A 10 a. Conferência ... pela BGI de 22-25 de outubro de 2015, em ... conferência está celebrando seu 10 o. aniversário este ano. ... uma das reuniões mais influentes do mundo no ramo ... entusiastas e prazerosos. A ICG-10 se ...
Breaking Biology News(10 mins):SMI Shows First Eye Tracking Upgrade for Augmented Reality Glasses 2SMI Shows First Eye Tracking Upgrade for Augmented Reality Glasses 3Digital Forensics Market - The Market Represents a Compound Annual Growth Rate (CAGR) of 11.3% From 2015 to 2020 2A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 2A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 3
... trials can be time-consuming, expensive and intrusive, but they ... Space Institute in Tullahoma have developed an invention that ... the virtual world. Called "digital Eye Bank," the ... eyes for researchers to use when testing their inventions. ...
... NY) Researchers at Albert Einstein College of Medicine ... mechanism that the immune system uses to respond to infection. ... lead to new strategies for boosting effectiveness of all vaccines. ... journal Immunity . Grgoire Lauvau, Ph.D.One way the ...
... in Australia has been discovered by a specialist on ... family Pyrgodesmidae have been found among bulk samples in two ... widespread in Australia,s tropical and subtropical forests, but are also ... open access journal ZooKeys . "Most ...
Cached Biology News:University of Tennessee Space Institute researchers make clinical trials a virtual reality 2Early activation of immune response could lead to better vaccines 2Millipede family added to Australian fauna 2
(Date:9/1/2015)... (PRWEB) , ... September 01, 2015 , ... ... high-quality recombinant antibodies, announced today that the National Institutes of Health (NIH) has ... which will be administered by the NIH’s National Institute of Diabetes and Digestive ...
(Date:9/1/2015)... 2015   Medfusion, Inc., a patient ... doctors and patients, today announced a $3 million ... -based venture capital firms.   "We ... Bull City Venture Partners and Hatteras Venture Partners," ... Executive Chairman. "Both firms, experience working at the ...
(Date:9/1/2015)... Shire plc (LSE: SHP, NASDAQ: SHPG ) announces ... of Directors as a Non-Executive Director. Sara will also be ... the Shire Board. Both appointments will be effective as of ... President and Chief Executive Officer of Dun & Bradstreet, Inc. ... D&B, she helped drive the transformation of the company from ...
(Date:8/31/2015)... , Aug. 31, 2015 Research and ... the "Argentina Biomedical Sensors Market - Growth, Trends ... The Argentina Biomedical Sensors market is estimated ... 1.17% over the period 2014-2020 The near ... the genetic formulation of each individual. These sensors can ...
Breaking Biology Technology:AxioMx Announces Receipt of SBIR Grant for DNA-Protein Complex Antigen Development 2AxioMx Announces Receipt of SBIR Grant for DNA-Protein Complex Antigen Development 3Medfusion Secures Funding to Continue Evolution and Advance Mobile Strategy 2Medfusion Secures Funding to Continue Evolution and Advance Mobile Strategy 3Shire Appoints Sara Mathew to Board of Directors 2Argentina Biomedical Sensors Market Report 2015 - Growth, Trends & Forecasts 2014-2020 2
... Reported in CUSTOM I, II, and III ... ... ,XTENT, Inc. (Nasdaq: XTNT ) today announced positive long-term follow-up,data from ... the Custom NX(R) drug eluting stent (DES) system in treating,patients with coronary ...
... Proximity Systems ... WorkStations: one year later, ... 400,Proximity Systems Computer WorkStations, Centerpoint Medical Center offers,favorable reviews ... are satisfying the needs of the,hospital,s nurses, physicians, patients, ...
... Mentice, a leading,supplier of solutions for medical simulation, ... President of Global Marketing., Effective from today ... marketing activities globally from a corporate standpoint., ... of experience of global,sales, marketing and product management ...
Cached Biology Technology:Custom NX(R) Drug Eluting Stent System Continues to Demonstrate Favorable Outcomes in Challenging Patient Populations at One, Two and Three Years 2Custom NX(R) Drug Eluting Stent System Continues to Demonstrate Favorable Outcomes in Challenging Patient Populations at One, Two and Three Years 3In-Room Computers and Wall-Mounted Proximity Systems Computer WorkStations Deliver Increased Efficiency; Improved Patient Care 2In-Room Computers and Wall-Mounted Proximity Systems Computer WorkStations Deliver Increased Efficiency; Improved Patient Care 3In-Room Computers and Wall-Mounted Proximity Systems Computer WorkStations Deliver Increased Efficiency; Improved Patient Care 4Mentice Appoints Bjorn Larsson as Vice President of Global Marketing 2
XBP-1 (F-4)...
Mouse monoclonal [AE3] to Cytokeratin 1 - 8, prediluted ( Abpromise for all tested applications). Antigen: Tissue / cell preparation - Human epidermal cells. Entrez GeneID: 140807 Swiss P...
pETDuet-1 is designed for the coexpression of two target genes....
...
Biology Products: