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Hippocampal and thalamic neuronal metabolism in a putative rat model of schizophrenia
Date:10/31/2013

Brain-derived neurotrophic factor (BDNF) and neuregulin 1 (NRG1) are important genes and signaling pathways that are altered in schizophrenia. To date, no studies have reported magnetic resonance spectroscopy in a rat model of schi-zophrenia induced by early growth response protein 3 gene (Egr3) transfection. Prof. Guolin Ma and colleagues from China-Japan Friendship Hospital, China used multivoxel proton magnetic resonance spectroscopy to study neuronal metabolite content in rats transfected with the Egr3 gene as a putative model of schizophrenia. 3.0 T proton magnetic resonance spectroscopy of in vivo brain tissues showed metabolic abnormalities in hippocampal and thalamic neurons of growth response protein 3 transfected rats. These findings, published in the Neural Regeneration Research (Vol. 8, No. 26, 2013), provide imaging evidence that may be useful in the early diagnosis and pathogenesis of schizophrenia.


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Contact: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
Source:Eurekalert  

Page: 1

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