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Hijacking stress response in cancer
Date:7/2/2013

ors of Nrf2 to inhibit cancer " said Anju Singh, PhD, lead author of the study and assistant scientist in the Bloomberg School's Department of Environmental Health Sciences. Using an integrated genomics and 13C-based metabolic flux system wide association analysis, we demonstrate that Nrf2 modulates glucose flux through PPP and TCA cycles in cancer cells. Biswal concludes that "This study reinforces the idea that targeting Nrf2 with small molecule inhibitors will starve the cancer cells by affecting metabolic pathways as well as decrease antioxidants and detoxification genes to intervene in therapeutic resistance." Biswal's group has been working with the National Center for Advancing Translational Sciences at NIH to develop Nrf2 inhibitors for cancer therapy.


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Contact: Tim Parsons
tmparson@jhsph.edu
410-955-7619
Johns Hopkins University Bloomberg School of Public Health
Source:Eurekalert

Page: 1 2

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