Navigation Links
Hijacked supplies for pathogens
Date:7/23/2010

When it infects the lungs, the Legionnaire's bacterium Legionella pneumophila causes acute pneumonia. The pathogen's modus operandi is particularly ingenious: it infiltrates deliberately into cells of the human immune system and injects a host of proteins which then interfere in the normal cellular processes. Scientists from the Max Planck Institute of Molecular Physiology in Dortmund have now discovered how Legionella reprogrammes the cells to ensure its own survival and to propagate. They examined a protein used by the pathogen to divert the material transport within the cells for its own purposes. (Science, July 22, 2010)

During a Legionella infection, the bacteria are engulfed by immune cells and bound by a membrane in the cell interior. Legionella protects itself against destruction by releasing proteins that reprogramme the human cell and exploit it for its own purposes. One of these proteins is DrrA. Previous studies succeeded in demonstrating that DrrA diverts the material transport in human cells in the direction of the pathogen, using what are known as Rab proteins for this purpose.

Rab proteins are switch molecules that coordinate transport vesicles within cells. In this capacity, they ensure that these membrane-bound vesicles reach the correct destination at the right time. Of the total of 60 different Rab proteins, DrrA specifically uses the Rab1 molecule for its own purposes: it deposits Rab1 on the membrane enclosing the bacteria and activates it. As a result, part of the material transport of the human cell is diverted to the vesicle containing the bacterium.

The structural and biochemical analysis of DrrA led the Dortmund-based scientists to make an astonishing discovery: DrrA is not only capable of activating Rab1, it also appears to be able to extend its activated state. To this end, DrrA blocks the switching-off of Rab1 and the necessary recognition site for regulatory protei
'/>"/>

Contact: Dr. Peter Herter
peter.herter@mpi-dortmund.mpg.de
49-231-133-2500
Max-Planck-Gesellschaft
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Healthy watersheds can sustain water supplies, aquatic ecosystems in a changing climate
2. Killer bees may increase food supplies for native bees
3. ORNL scientists hone technique to safeguard water supplies
4. Targeting children effective use of limited supplies of flu vaccine and could help control flu spread
5. Scientists urge global action to preserve water supplies for billions worldwide
6. Turning over a new leaf for future energy supplies
7. Polarized light guides cholera-carrying midges that contaminate water supplies
8. Soil-borne pathogens drive tree diversity in forests, study shows
9. Neiker-Tecnalia underlines the need to maintain programs for monitoring pathogens in wildlife
10. Genomes of citrus canker pathogens decoded
11. New technology enables machines to detect microscopic pathogens in water
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Hijacked supplies for pathogens
(Date:9/16/2014)... can take up residence in and on the human ... symptom, according to new research at Washington University School ... healthy individuals carry about five types of viruses on ... Central Biology . The study is the first comprehensive ... people. , The research was conducted as part ...
(Date:9/16/2014)... interaction between viruses, bacteria, and their environment is ... collaboration between Matthew Sullivan, associate professor in the ... Biology and Steven Hallam from the University of ... are drivers of nutrient and energy cycles that ... is changing, so are the environments these bacteria ...
(Date:9/16/2014)... 2014 Schizophrenia is associated with increased rates and ... research suggests that the relationship between schizophrenia and smoking ... use nicotine to self-medicate symptoms and cognitive impairment associated ... the current issue of Biological Psychiatry , sheds ... level of nicotine receptors in the brain was lower ...
Breaking Biology News(10 mins):Healthy humans make nice homes for viruses 2Healthy humans make nice homes for viruses 3New research decodes virus-host interactions in ocean dead zones 2New research decodes virus-host interactions in ocean dead zones 3Smoking and schizophrenia linked by alterations in brain nicotine signals 2
... For two weeks in March, some of the greatest names ... take part in public discussions on how fundamental discoveries in ... understanding of life and civilization -- and our grasp of ... & Life of Beginnings," this one-of-a-kind program was organized by ...
... Global climate rapidly shifted from a relatively ice-free world ... 34 million years ago. What happened? What changed? ... a new perspective on the nature of changing climatic ... and has important implications for predicting future climate changes. ...
... CLEMSON, SCIn areas of the U.S. where golfers can ... traffic, and frost can wreak havoc on healthy greens ... Creeping bentgrass ( Agrostis stolonifera var. palustris Huds. ), ... is often preferred because of its year-round green color, ...
Cached Biology News:World's top minds to celebrate 'the birth and life of beginnings' 2World's top minds to celebrate 'the birth and life of beginnings' 3World's top minds to celebrate 'the birth and life of beginnings' 4CO2 drop and global cooling caused Antarctic glacier to form 2This grass is still greener 2
(Date:9/15/2014)... An interdisciplinary team of researchers led by Northeastern ... constructing precise inter-nanotube junctions and a variety of ... is facile and easily scalable, which will allow ... nanotube networks for use in applications ranging from ... everything from cars to sports equipment. , Their ...
(Date:9/15/2014)... 15, 2014 Zymo Research Corp., has announced ... for safe ambient temperature storage and transport of ... infectivity of agents in such samples is completely ... of the viral nucleic acids for subsequent analyses.  ... epidemic in West Africa ...
(Date:9/15/2014)... DUBLIN , Sept. 15, 2014 Research ... "Whole Exome Sequencing Market by Product, by Services, by Technology, ... their offering. Whole Exome Sequencing (WES) is ... the genome, i.e. the exon. The exome, which is the ... of the total genome and is actually converted into proteins ...
(Date:9/15/2014)... (PRWEB) September 15, 2014 Applied ... implantable silicones for the medical device and critical ... gel for the implantable medical device market. ... crosslink technology delivering a silicone gel with improved ... Dual Matrix technology consists of two crosslinked networks ...
Breaking Biology Technology:Northeastern University Researchers Develop Novel Method for Working with Nanotubes 2Safe storage and transport of Ebola, Mers-CoV, and other viruses: Groundbreaking viral inactivation solution capable of preserving nucleic acids 2Safe storage and transport of Ebola, Mers-CoV, and other viruses: Groundbreaking viral inactivation solution capable of preserving nucleic acids 3Global Whole Exome Sequencing (Systems, Kits, Library Preparation, Target Enrichment) Market by Product, by Services, by Technology, by Application - Forecast to 2018 2Global Whole Exome Sequencing (Systems, Kits, Library Preparation, Target Enrichment) Market by Product, by Services, by Technology, by Application - Forecast to 2018 3Applied Silicone Launches Silicone Gel System with Dual Matrix Technology 2
... Almost everybody knows the University of Wisconsin-Madison ... But a new study has produced figures to back ... in the University Research Park , located three ... university research. And the concentration of these innovative firms, ...
... has heard of identity theft (IDT), yet unless you have ... high risk. An alarming figure is that over half of ... place of business, employer, or other entity (not-for-profit or local, ... are required under one or more federal and state laws ...
... Madison-based National Stem Cell Bank has announced it ... of California-San Francisco , giving it 13 of the 21 ... Donley, executive director of the WiCell Research Institute , ... optimistic that it eventually will have all 21 federally approved ...
Cached Biology Technology:Impact of research park firms pegged at $680M 2Identity theft: The business time bomb 2Identity theft: The business time bomb 3Identity theft: The business time bomb 4Nation's only stem cell bank will receive UC-San Francisco cell line 2
... NeuroLog System is a compact, versatile & modular ... of purposes including: Intracellular, Extracellular, Transducer & ... The NeuroLog Case & Power Supply unit (NL900D) ... Modules are not only powered by this unit, ...
Rat Epidermal Keratinocytes (REK) (>500,000 cells)...
... Precision Model 410 is a four-channel general purpose ... small signals from sources which may have a ... channel consists of a high gain/low noise amplifier, ... and an output offset control. A control knob ...
Porcine Coronary Artery Endothelial Cells (PCAEC) (>500,000 cells)...
Biology Products: